Longitudinal investigation of neurobiological changes across pregnancy by Yanbin Niu, Benjamin N. Conrad, M. Catalina Camacho, Sanjana Ravi, Hannah A. Piersiak, Lauren G. Bailes, Whitney Barnett, Mary Kate Manhard, David A. Cole, Ellen Wright Clayton, Sarah S. Osmundson, Seth A. Smith, Autumn Kujawa, Kathryn L. Humphreys

“…Each visit includes anatomical and diffusion-weighted MRI, and assessments of waking salivary hormones, hair hormones, and inflammatory cytokines. Here we observe a reduction in gray matter volume and an increase in neurite density index (NDI), a proxy of axon density, in white matter tracts across pregnancy. …”
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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro by Claudia J. Labrador-Rached, Rebecca T. Browning, Laura K. Braydich-Stolle, Kristen K. Comfort

“…However, lower, subtoxic PtNP concentrations were able to elicit multiple stress responses, secretion of proinflammatory cytokines, and modulation of insulin-like growth factor-1 dependent signal transduction. …”
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese, Rosa Terracciano, Rosario Maselli

“…Eosinophilic asthma includes either allergic or nonallergic phenotypes underlying immune responses mediated by T helper (Th)2 cell-derived cytokines, whilst neutrophilic asthma is mostly dependent on Th17 cell-induced mechanisms. …”
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Microglial C/EBPβ-Fcgr1 regulatory axis blocking inhibits microglial pyroptosis and improves neurological recovery by Jing Li, Yubing Yang, Chenguang Zhao, Jinghao Zhao, Xiaohui Wang, Shengshou Ye, Dong Wang, Chengdong Zhou, Jie Li, Shuang Wang, Ke Li, Chunmiao Liu, Xijing He, Jie Qin

“…Knocking down C/EBPβ in the spinal cord attenuated microglia pyroptosis, reduced the production of proinflammatory cytokines, and inhibited neuronal apoptosis. Mechanistically, C/EBPβ promoted the transcription of Fcgr1, which was involved in activating microglia pyroptosis. …”
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The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals by Karen Ingrid Tasca, Juliana Trindade Caleffi, Camila Renata Correa, Mariana Gatto, Caio Cavassan de Camargo, Monica Bannwart Mendes, Marjorie de Assis Golim, Mara Biasin, Lenice do Rosário de Souza

“…The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. …”
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Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin by Fang Zhang, Luyi Wu, Jimeng Zhao, Tingting Lv, Zhihai Hu, Zhijun Weng, Shuoshuo Wang, Huangan Wu, Huirong Liu

“…Numerous peripheral neurotransmitters, neuropeptides, and cytokines participate in the analgesic process of EA in visceral pain. …”
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The Interplay between the Bone and the Immune System by Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti

“…Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. …”
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Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica) by Takuhiro Uto, De-Xing Hou, Osamu Morinaga, Yukihiro Shoyama

“…We previously reported that 6-MSITC strongly suppresses cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines, which are important factors that mediate inflammatory processes. …”
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Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis by Masahito Ebina, Hiroyuki Taniguchi, Taku Miyasho, Shingo Yamada, Naoko Shibata, Hiromitsu Ohta, Shu Hisata, Shinya Ohkouchi, Tsutomu Tamada, Hidekazu Nishimura, Akitoshi Ishizaka, Ikuro Maruyama, Yoshinori Okada, Kondo Takashi, Toshihiro Nukiwa

“…To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…Levels of C reactive protein, immunoglobulin (IgG, IgM, IgA, and IgE), and complements (C3, C4) were detected by rate nephelometry immunoassay. And Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were detected by Cytometric Bead Array. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…Obesity is associated with reduced levels of certain inhibitory cytokines and higher expression of T-cell exhaustion markers. …”
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The PD-1 with PD-L1 Axis Is Pertinent with the Immune Modulation of Atrial Fibrillation by Regulating T Cell Excitation and Promoting the Secretion of Inflammatory Factors by Guodong Chang, Yingwei Chen, Zichang Liu, Yong Wang, Wenkun Ge, Yongan Kang, Shuling Guo

“…After α interferon upregulated PD-L1 expression in cells, the ability of mDCs to stimulate T cells to secrete IL-2, IL-10, and IFN-γ cytokines was reversed in patients in the atrial fibrillation group, and the differences compared with the control group were not statistically significant (P>0.05). …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Furthermore, IRAK3 siRNA treatment markedly decreased the expression of inflammatory cytokines and microglial activation via the NF-κB/IL-17A signaling pathway. …”
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Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…These signals act as ligands to Toll-like receptors (TLRs), triggering the production of cytokines and inducing innate inflammation. In smokers who develop COPD there appears to be a specific pattern of inflammation in the airways and parenchyma as a result of both innate and adaptive immune responses, with the predominance of CD8+ and CD4+ cells, and in the more severe disease, with the presence of lymphoid follicles containing B lymphocytes and T cells. …”
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PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis by Xiaoe He, Xiangyan Jiang, Jiayin Guo, Hui Sun, Jing Yang

“…On one hand, PANoptosis acts as a protective mechanism by inducing the death of infected cells to eliminate pathogens and releasing pro-inflammatory cytokines to amplify the immune response. On the other hand, bacteria can exploit PANoptosis to evade host immune defenses. …”
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Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons by Tan Jingjing, Yadav Manoj Kumar, Devi Sushma, Kumar Manish

“…Subsequently, an increase (p < 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. …”
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Splenic Stromal Cells from Aged Mice Produce Higher Levels of IL-6 Compared to Young Mice by Jihyun Park, Takuya Miyakawa, Aya Shiokawa, Haruyo Nakajima-Adachi, Masaru Tanokura, Satoshi Hachimura

“…Inflamm-aging indicates the chronic inflammatory state resulting from increased secretion of proinflammatory cytokines and mediators such as IL-6 in the elderly. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Rheumatoid arthritis and other inflammatory diseases are characterized by diurnal changes in cytokines, leading to inflammatory flares, with peak disease activity in the early morning. …”
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Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? by Fulvia Ceccarelli, Matteo Saccucci, Gabriele Di Carlo, Ramona Lucchetti, Andrea Pilloni, Nicola Pranno, Valeria Luzzi, Guido Valesini, Antonella Polimeni

“…Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue.…”
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Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population by L. Akhmaltdinova, V. Sirota, V. Zhumaliyeva, D. Babenko, I. Kadyrova, Z. Tauesheva, D. Taizhanova, A. Ibraeva, M. Maratkyzy, A. Turmukhambetova

“…The data of our study show that most of the basic proinflammatory cytokines are involved in the systemic process and their levels do not depend on the level of tissue differentiation. …”
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