Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia, caused in 95 % of the cases by a cytogenetic abnormality characterized by the reciprocal translocation between chromosomes 9 and 22 t(9; 22) (q34; q11), resulting in Philadelphia chromosome (Ph).Considering that CML cure is only possible with a successful bone marrow transplantation and that there are resistance cases to the tyrosine kinase inhibitor Imatinib Mesylate, prescribed in first line drug treatment; it is important to know in detail the genes and proteins that are possibly altered in CML, favoring effective therapeutic strategies, optimized diagnosis and minimal residual disease detection. …”
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A Rare Prenatal Case: Greig Cephalopolysyndactyly Syndrome by Tilbe Hakçıl, Gülsüm Kayhan, Tuncay Nas, Pınar Telli Celtemen, Meral Yirmibeş Karaoğuz

“…A 32-year-old woman, in her 21st week of the first pregnancy, was referred to our center for cytogenetic analysis of amniotic fluid because of the detection of polyhydramnios, polydactyly, aortic stenosis, and the absence of vesica biliaris visualization on fetal ultrasound. …”
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Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice by Sahdeo Prasad, Smita Srivastava, Madhulika Singh, Yogeshwer Shukla

“…Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage. Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P<.05). …”
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Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit by Orkun Çetin, Fatma Ferda Verit Atmaca, Ali Galip Zebitay, Ayşegül Deregözü, Begüm Aydoğan, Seda Keskin, Oğuz Yücel

“… OBJECTİVE: The objective of this study is to identify the annual variations amniocentesis indications such as change in maternal age, cytogenetic results, and other indications. Another outcome is the investigation of the relationship between indications for amniocentesis and the distribution of chromosomal abnormalities. …”
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Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing by Seong Gu Heo, Eun Pyo Hong, Ji Wan Park

“…Normal-karyotype acute myeloid leukemia (NK-AML) is a highly malignant and cytogenetically heterogeneous hematologic cancer. We searched for somatic mutations from 10 pairs of tumor and normal cells by using a highly efficient and reliable analysis workflow for whole-exome sequencing data and performed association tests between the NK-AML and somatic mutations. …”
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A case report of hermaphrodite goat: clinical and genetic approach by Çağlayan Özel, Gonca Şen, Mustafa Hitit, Nadir Koçak, Aydın Güzeloğlu, Ahmet Semacan, Ercan Kurar, Ercan

“…This case report describes clinical examination and cytogenetic and molecular genetic analyses of a hermaphrodite mixed Maltese breed goat that was referred to the Gynecology Clinic of the Faculty of Veterinary Medicine, Selcuk University in 2010. …”
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An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review by Reina Takeda, Kazuaki Yokoyama, Seiichiro Kobayashi, Toyotaka Kawamata, Sousuke Nakamura, Tomofusa Fukuyama, Mika Ito, Nozomi Yusa, Eigo Shimizu, Nobuhiro Ohno, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Kaoru Uchimaru, Arinobu Tojo

“…Bone marrow examinations revealed chronic myelomonocytic leukemia-like disease with a chromosomal translocation of t(11;22)(q23;q13) as a solo cytogenetic abnormality, resulting in the diagnosis of t-MN. …”
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Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Li... by Javier De Luca-Johnson, Jose I. Ruades Ninfea, Lauren Pearson, Joanna Conant, Ronald Bryant, Neil A. Zakai, Mary E. Tang

“…The patient was a 51-year-old previously healthy man who presented with three months of worsening dyspnea and was found to have a white count of 216,000/cmm, of which 84% were eosinophil lineage. Cytogenetic analysis revealed a t(5;12)(q31~33;p13). …”
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Domestication of <i>Avena magna</i> Murphy et Terrell: a wild tetraploid oat species endemic of Morocco by N. Saidi, N. Shaimi, A. S. Idrissi, A. Souihka, F. Gaboun, C. Al Faiz, G. Ladizinsky

“…Morphological characterization and cytogenetic analysis of derivative hybrid seeds were made to determine their ploidy level and select the seeds with 2n = 28. …”
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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review by M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques, M. Lima

“…Absence of CD56 expression on the neoplastic NK cells may impose difficulties in the diagnosis, which requires morphological, immunophenotypic, histopathological, immunohistochemical, cytogenetic, and molecular studies.…”
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Clinical efficacy and safety of first‐line nilotinib or imatinib therapy in patients with chronic myeloid leukemia—Nationwide real life data by Petra Belohlavkova, Daniela Zackova, Hana Klamova, Edgar Faber, Michal Karas, Lukas Stejskal, Eduard Cmunt, Olga Cerna, Ivana Jeziskova, Katerina Machova Polakova, Pavel Zak, Tereza Jurkova, Marika Chrapava, Jiri Mayer

“…Results Nilotinib‐treated patients achieved complete cytogenetic response (CCyR) and major molecular response more rapidly than imatinib‐treated patients. …”
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Prenatal Diagnosis of 4p and 4q Subtelomeric Microdeletion in De Novo Ring Chromosome 4 by Halit Akbas, Naci Cine, Mahmut Erdemoglu, Ahmet Engin Atay, Selda Simsek, Aysegul Turkyilmaz, Mehmet Fidanboy

“…A 23-year-old patient (gravida 1, para 0) referred for amniocentesis due to abnormal maternal serum screening result in the 16th week of second pregnancy. Cytogenetic analysis of cultured amniyotic fluid cells revealed out ring chromosome 4. …”
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Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience by Aysel Kalaycı Yiğin, Mehmet Seven, Deniz Ağırbaşlı, Gizem Erdoğan Erdur

“…In azoospermic and oligospermic patients, cytogenetic tests, Y-chromosome microdeletions and NGS panel screening tests can give effective information before the use of assisted reproductive techniques.…”
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Assessment of Cytogenotoxicity of Plastic Industrial Effluent Using Allium cepa Root Tip Cells by Jibril Sani Mohammed, Yahaya Mustapha, Madu Abdulkarim Him, Zandam Nuhu Danladi

“…Following 96 hours, the four treated root tips from each replication’s bulbs were harvested and subjected to the acetoorcein squash technique for cytogenetic analysis. High concentrations of the industrial effluents had severe development retarding effects on the root tips. …”
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Relationship between oxidative stress biomarkers and micronuclei scoring as a biomarker for DNA damage in Egyptian nicotine-dependent smokers: A cross-sectional study by Asmaa Mahmoud Mohammed, Dalia Farouk, Adel F. Hashish

“…All participants have been clinically evaluated and investigated for oxidative stress biomarkers, cytogenetic analysis of BMNi, and urinary cotinine creatinine ratio concentration. …”
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Prenatal Diagnosis of Rare Familial Unbalanced Translocation of Chromosomes 7 and 12 by Berrin Tezcan, Foteini Emmanouella Bredaki

“…Genome-wide array analysis and cytogenetic results from the amniotic fluid showed unbalanced translocation in chromosomes 7 and 12 with deletion of an approximately 16.5 Mb and a duplication of 6.1 Mb, respectively, Arr 7q34q36.3(142,668,576-159,161,648)x1,12q24.32q24.33(127,708,720-133,777,560)x3, karyotype (der (7) t(7;12) (q34;q24)pat). …”
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Prenatal Identification and Molecular Characterization of Two Simultaneous De Novo Interstitial Duplications of Chromosomal Regions 7p22.1p21.1 and 15q24.1 by Sabrina C. Burn, Kali Swift, Maria Palmquist

“…Amniocentesis was completed for a healthy gravida 4 para 3 woman due to her advanced maternal age and concurrent ultrasound findings of partial vermian agenesis, choroid-plexus cysts, and hypoplastic nasal bone. Cytogenetic analysis of cultured amniocytes by conventional chromosome analysis, comparative genomic hybridization, and fluorescence in situ hybridization revealed two interstitial duplications of the chromosomal regions 7p22.1p21.1 and 15q24.1, leading to partial trisomy of 7p and 15q and karyotype 46,XY,dup(7)(p22.1-p21.1),dup (15)(q24.1). …”
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Renal Failure Associated with APECED and Terminal 4q Deletion: Evidence of Autoimmune Nephropathy by Mohammed Al-Owain, Namik Kaya, Hamad Al-Zaidan, Ibrahim Bin Hussain, Hadeel Al-Manea, Hindi Al-Hindi, Shelley Kennedy, M. Anwar Iqbal, Hamad Al-Mojalli, Albandary Al-Bakheet, Anne Puel, Jean-Laurent Casanova, Saleh Al-Muhsen

“…Terminal 4q deletion is also a rare cytogenetic abnormality that causes a variable syndrome of dysmorphic features, mental retardation, growth retardation, and heart and limb defects. …”
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Molecular cytological analysis of alien introgressions in common wheat lines created by crossing of <i>Triticum aestivum</i> with <i>T. dicoccoides</i> and <i>T. dicoccum</i> by О. A. Orlovskaya, I. N. Leonova, L. A. Solovey, N. I. Dubovets

“…Assessment of cytological stability was carried out on the basis of chromosome behavior in microsporogenesis. A molecular cytogenetic analysis of introgression wheat lines indicated that the inclusion of the genetic material of wild and domesticated emmer was carried out mainly in the form of whole arms or large fragments in the chromosomes of the B genome and less extended inserts in the A genome. …”
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The molecular prognostic scoring system for normal karyotype myelodysplastic syndromes by Wei Wang, Yudi Zhang, Wenli Yang, Xiaozhen Liu, Lingxu Jiang, Wei Lang, Yingwan Luo, Xinping Zhou, Lu Wang, Li Ye, Ying Xu, Liya Ma, Hongyan Tong

“…Abstract Background Molecular-clinical prognostic models for Myelodysplastic syndromes (MDS) offer more accurate prognosis predictions, yet existing models often overlook the heterogeneity of mutational profiles against the cytogenetic background. Moreover, how to apply these models in regions where large panel NGS is unaffordable remains a significant challenge to be addressed. …”
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