Combined induction by Cu(II) and veratrole enhances the degradation of high molecular weight polyaromatic hydrocarbons by Fusarium dlaminii ZH-H2 by Jiayuan Gao, Mingyue Qi, Xiaomin Wang, Xuan Feng, Jiahui Li, Guangwei Zhang, Shengdong Feng, Zhixin Yang, Guohui Ning

“…The combined CL treatment not only significantly stimulated Lip activity, but also induced the expression of genes coding for non-ligninolytic enzymes, which contributed to the degradation of PAHs. These included cytochrome P450 monooxygenase (EC:1.–.-.-) and downstream PAH converting enzymes such as aldehyde dehydrogenase (EC:1.2.1.3), NADP-dependent ethanol dehydrogenase (EC:1.1.1.2), ethanol dehydrogenase (EC:1.1.1.156], tryptophan 2,3 dioxygenase (EC:1.13.11.52), gentisate 1,2-dioxygenase (EC:1.13.11.5), salicylate hydroxylase (EC:.14.13.1) β-hexokinase (EC:3.2.1.52), and glutathione transferase (EC: 2.5.1.18). …”
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Effects of typical plant growth regulator chlormequat chloride on alkaloidal compounds in Corydalis yanhusuo and molecular mechanisms by Zixuan Du, Jiayin Cao, Jie Meng, Heng Zhou, Qing Hu, Ling Li, Yun Liao, Shui Miao, Wenting Li, Shen Ji, Tongshuai Wang

“…It was suggested that the level of cytochrome P450 enzymes, primarily involved in the biosynthesis of benzylisoquinoline alkaloids, was inhibited by chlormequat chloride. …”
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Reduced Glutathione Promoted Growth Performance by Improving the Jejunal Barrier, Antioxidant Function, and Altering Proteomics of Weaned Piglets by Zhimei Tian, Yiyan Cui, Miao Yu, Dun Deng, Zhenming Li, Xianyong Ma, Mingren Qu

“…Through the proteomics analysis of the jejunal mucosa using 4D-DIA, the KEGG pathway enrichment analysis showed that differentiated proteins were significantly enriched in redox homeostasis-related pathways such as glutathione metabolism, cytochrome P450, the reactive oxygen species metabolic pathway, the oxidative phosphorylation pathway, and the phosphatidylinositol 3-kinase-serine/threonine kinase pathway in GSH2 vs. …”
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Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…Dietary vitamin E supplementation significantly upregulated the expression of genes involving vitamin E transfer, ovarian development, and hormone, including alpha-tocopherol transfer protein, luteinizing hormone, follicle-stimulating hormone, vitellogenin receptor (vgr), vitellogenin (vg), 17-beta-hydroxysteroid dehydrogenase (17β-hsd), cyclin-dependent kinase 2 (cdk2), and cytochrome P450 family 17 (cyp-17), with the highest expression levels detected in the 209.31 mg/kg group (P < 0.05). …”
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The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion by Ping Wang, Min Cong, Tianhui Liu, Aiting Yang, Guangyong Sun, Dong Zhang, Jian Huang, Shujie Sun, Jia Mao, Hong Ma, Jidong Jia, Hong You

“…Signal pathway analysis revealed that TGF-β1 impaired the pathways of cell cycle and cytochrome P450 detoxification, and EGF reverted TGF-β1 effects through activating MAPK and PI3K-Akt pathway. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…The two genotypes displayed distinct gene expression patterns of nitric oxide (NO)-related molecules inducible NO synthase (iNos) and arginase (Arg2), insulin receptor-related signaling factors: cluster of differentiation 36 (Cd36), ecto-nucleotide pyrophosphatase/phosphodiesterase (Enpp), protein tyrosine phosphatase N1 (Ptpn1), cytochrome P450 omega-hydroxylase 4A14 (Cyp4a14), acyl-CoA synthetase 1 (Acsl1) and phosphatase and tensin homolog (Pten). …”
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A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Combining RNA-seq and whole genome pool-seq identified a 220 Kb genomic duplication enhancing the expression of multiple contiguous cytochrome P450s in the resistant line. The genomic architecture of the duplicated loci was elucidated through long read sequencing, evidencing its transposon-mediated evolutionary origin. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…Cytochrome P450 2E1 (CYP2E1) is a key target protein in the development of alcoholic and nonalcoholic fatty liver disease (FLD). …”
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Rhabdomyolysis and Acute Kidney Injury Requiring Dialysis as a Result of Concomitant Use of Atypical Neuroleptics and Synthetic Cannabinoids by Aiyu Zhao, Maybel Tan, Aung Maung, Moro Salifu, Mary Mallappallil

“…Recent studies have showed the involvement of cytochromes P450s (CYPs) in biotransformation of SCBs. …”
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Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels by Lněničková Kateřina, Skálová Lenka, Stuchlíková Lucie, Szotáková Barbora, Matoušková Petra

“…In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. …”
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Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes by Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou

“…THC is predominantly eliminated via the cytochromes P450 (CYPs), whereas CBD is eliminated through both CYPs and UDP‐glucuronosyltransferases (UGTs). …”
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