Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…Additionally, we found an increased deviation from initial curative to palliative intent in the P2 group (6.4% changed in P2 vs 2.2% in PP and 3.5% in P2) primarily driven by disease progression. …”
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Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…Managing patients with chondroblastoma should encompass curative and functional aspects.…”
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Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients by Guenda Di Benedetto, Ignazio Barca, Laura De Gregorio, Claudia Scollo, Fiorenza Gianì, Federica Martorana, Marco Russo, Francesco Frasca, Gabriella Pellegriti, Gabriella Pellegriti, Giulia Sapuppo

“…The goal should be to subject patients to surgery for prophylactic and not curative purposes, i.e., before the onset of MTC, given the high risk of persistent or recurrent disease also in pediatric/adolescent patients.…”
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Control of Ectoparasitic Monogenean Infestation on GIFT Tilapia (Oreochromis sp.) using Salt Addition by Yani Hadiroseyani, L.S. Harti, Sri Nuryati

“…Salt addition is one of disease curative and controlling techniques which is cheap, easy and environmental friendly as well as effective to control ectoparasites in freshwater environment. …”
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AN INTEGRATED INFORMATION SYSTEM ON BIORESOURCE COLLECTIONS OF THE FASO OF RUSSIA by S. A. Lashin, D. A. Afonnikov, M. A. Genaev, F. V. Kazantsev, E. G. Komyshev, E. A. Oschepkova, А. V. Petrov, D. A. Rasskazov, A. A. Smirnova, N. A. Kolchanov

“…The portal contains the following functional sections: the home page containing general information on bioresource collections, the catalog of collections, individual pages for each particular collection with a short description (information about curators, statistical information about the number of storage units in the collection and the number of publications, as well as a link to the catalog of storage units of this BRC). …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Integration of mRECIST with AFP or PIVKA-II responses allowed for accurate prediction of MPR and could support decision-making on subsequent curative-intent treatment.Keywords: hepatocellular carcinoma, chemoembolization therapeutic, systemic therapy, pathologic response, response evaluation criteria in solid tumors…”
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Longitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer by Simon Boeke, Jonas Habrich, Sarah Kübler, Jessica Boldt, Fritz Schick, Konstantin Nikolaou, Jens Kübler, Cihan Gani, Maximilian Niyazi, Daniel Zips, Daniela Thorwarth

“…Methods 27 patients treated with curative RT on the 1.5 T MR-Linac with at least weekly DWI in treatment position were included into this prospective analysis and divided in four risk groups (HPV-status and localisation). …”
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Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…Antenatal screening would identify HCV-positive mothers and allow follow-up of their infants so that any infected mothers and infants could be offered effective curative therapy and prevent the progression of liver disease. …”
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Effectiveness of Noninvasive Positive Pressure Ventilation Combined with Enteral Nutrition in the Treatment of Patients with Combined Respiratory Failure after Lung Cancer Surgery... by Yongjun Zhang, Lanbo Liu, Dawei Li, Dongsheng Zhou

“…A total of 82 patients with combined respiratory failure after lung cancer surgery who were treated in our hospital from March 2016∼September 2021 were selected as the research subjects, and according to the random number table method, they were equally divided into the parenteral nutrition group (n = 41) with NIPPV + parenteral nutrition support treatment and the enteral nutrition group (n = 41) with NIPPV + enteral nutrition support treatment. The curative effects of two groups after treatment were compared, and the pulmonary function indexes (maximum expiratory pressure (PEmax), maximum midexpiratory flow rate (MMF), and maximum ventilation volume (MVV)), blood gas indexes (blood oxygen partial pressure (PaO2) and partial pressure of carbon dioxide (PaCO2)), oxygen metabolism indicators [mixed venous oxygen tension (PvO2) and central venous oxygen saturation (ScvO2)], nutritional status indicators (hemoglobin (HGB), serum albumin (ALB), and total protein (TP)), and nutritional score before and after treatment in two groups were detected, and the 6-month follow-up of the two groups was recorded. …”
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Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
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Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice by Daniel Ampomah Frimpong, Aliu Moomin, Samuel Asare Nkansah, Aaron Opoku Antwi, Abubakar Ibn Sidik, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah

“…The anti-plasmodial effects of VA at doses 0 – 300 mg/kg were assessed in Plasmodium berghei (strain ANKA)-infected mice using 4-day suppressive and Rane's curative tests. A combination of various fractions (1, 1/2, 1/4 and 1/16) of VA-artesunate or VA-amodiaquine was used to determine their experimental ED50 s (Zexp). …”
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Clinical observation on effect of Chinese herbal fumigation and washing with Xiwenjing Huoxue Tongluo Decoction on limb numbness after chemotherapy for malignant tumor (中药熏洗温经活血通络方... by WU Ying (吴莹), TIAN Weili (田薇莉)

“…The scores of Activity of Daily Living and Simplified Mc Gill Pain Questionnaire( SF-MPQ) were observed before and after treatment. The overall curative effect was evaluated according to the improvement of the symptoms and signs. …”
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A Meta analysis on effect of auricular point sticking and pressing therapy in the treatment of hyperemesis gravidarum (耳穴贴压法治疗妊娠恶阻临床疗效的Meta分析) by TIAN Tian (田恬), XIE Wei (谢薇), DENG Yunyan (邓云燕), LI zhongqing (李忠琴), ZHANG yang (张杨), ZHAO Su (赵苏)

“…The results of meta-analysis showed that: ① The curative effect rate of auricular point sticking and pressing therapy was superior to the basic treatment group ［MD = 2. 42, 95% CI (2. 14, 5. 45), z = 5. 16, P < 0. 00001］. ② The total effective rate of auricular point sticking and pressing therapy group was superior to the basic treatment group ［MD = 5. 01, 95% CI (2. 495, - 10. 07), z = 4. 52, P < 0. 00001］. …”
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Effect of modified Traditional Chinese Medicine hot compress technique in the treatment of osteoarthritis of the knee (改良式中药热敷技术治疗膝骨关节炎效果观察) by CUI Yangfang (崔杨芳), LIU Ai (刘爱), ZHANG Xuejian (张雪键), ZHAO Yue (赵月), QI Mengying (齐梦颖)

“…Conclusion Modified TCM hot compress technique has a remarkable curative effect in the treatment of knee osteoarthritis, which can relieve pain and improve the function of knee joint, and it is a safe technique in clinical practice . …”
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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…Notably, 20% (4/20) of patients underwent successful conversion to curative surgical resection. Treatment-related adverse events (TRAEs) mainly included elevated aspartate aminotransferase levels (19/20, 95.0%), elevated alanine aminotransferase levels (18/20, 90.0%), hypothyroidism (18/20, 90.0%), and reduced appetite (10/20, 50.0%). …”
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Surface water and flood-based agricultural systems: Mapping and modelling long-term variability in the Senegal river floodplain by Andrew Ogilvie, Cheickh Sadibou Fall, Ansoumana Bodian, Didier Martin, Laurent Bruckmann, Djiby Dia, Issa Leye, Papa Malick Ndiaye, Donissongou Dimitri Soro, Jean Homian Danumah, Jean-Claude Bader, Jean-Christophe Poussin

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Application of pediatric massage combined with Traditional Chinese Medicine application in antipyretic treatment of children with exogenous fever (小儿推拿联合中药敷贴在外感发热患儿退热中的应用)... by TANG Xianlan (汤先兰), GAN Na (甘娜), HUANG Biqiu (黄碧秋)

“…Methods Totally120 children with exogenous fever admitted to the hospital from July 2020 to June 2022 were included as study objects , and 60 of them were divided into control group based on the single-day and double-day admission sequencing method, and were treated with conventional western medicine antipyretic regimen; Another 60 cases were enrolled in the treatment group, and treated with massage combined with Traditional Chinese Medicine application. The curative effect, axillary temperature and antipyretic time between the two groups after systematic treatment were compared. …”
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Modification and analysis of context-specific genome-scale metabolic models: methane-utilizing microbial chassis as a case study by M. A. Kulyashov, R. Hamilton, Y. Afshin, S. K. Kolmykov, T. S. Sokolova, T. M. Khlebodarova, M. G. Kalyuzhnaya, I. R. Akberdin

“…We demonstrate that this pipeline can help reconstruct metabolic models that are similar to manually curated networks. Furthermore, the model is able to highlight previously overlooked pathways, thus advancing fundamental knowledge of non-model microbial systems or promoting their development toward biotechnological or environmental implementations.…”
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Clinical effect of auricular point pressing with beans combined with acupoint massage in the treatment of post-stroke constipation with Qi deficiency syndrome (耳穴压豆联合穴位按摩治疗中风后气虚便秘的... by LI Chenchen (李陈晨), YANG Yu (杨宇), FAN Yan (范艳), JIA Tieying (贾铁英), HU Shirong (胡世荣)

“…The control group was given oral administration of rhubarb and sodium bicarbonate tablets, while the study group received auricular point pressing with beans combined with acupoint massage. The curative effect of intervention was evaluated, and the Traditional Chinese Medicine (TCM) syndrome integrals of constipation, quality of life score and satisfaction with nursing service were compared between two groups . …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Despite advancements in therapeutic strategies, the 5-year survival rate for individuals undergoing curative resection remains between 10% and 15%. Consequently, identifying molecular targets that specifically inhibit the proliferation and metastasis of HCC cells is critical for improving treatment outcomes. …”
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