SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Each new or modified checklist item is accompanied by a detailed description, its rationale with supportive evidence, and examples of good reporting curated from EPDF trial protocols covering a range of therapeutic areas and interventions. …”
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Novel digital droplet inverse PCR assay shows that natural clearance of hepatitis B infection is associated with fewer viral integrations by Dong Li, Vikki Ho, Chiao-Fang Teng, Hung-Wen Tsai, Yuanyuan Liu, Sarah Bae, Harout Ajoyan, Jochen M. Wettengel, Ulrike Protzer, Brian S. Gloss, Rebecca J. Rockett, Rafid Al Asady, Jane Li, Simon So, Jacob George, Mark W. Douglas, Thomas Tu

“…Future studies are needed to determine if dynamics of integrated HBV DNA can inform the development of curative therapies.…”
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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…Cell-based therapies are being developed to meet the need for curative therapy in chronic kidney disease (CKD). Bone marrow- (BM-) derived mesenchymal stromal cells (MSCs) enhance tissue repair and induce neoangiogenesis through paracrine action of secreted proteins and extracellular vesicles (EVs). …”
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Chromosome-level reference genome assembly for the mountain hare (Lepus timidus) by Fekete, Zsófia, Absolon, Dominic E., Michell, Craig, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…The genome was assembled using 21× PacBio HiFi sequencing data and scaffolded using the Hi-C chromosome structure capture approach. After manual curation, the primary assembly length was 2,695,305,354 bp with N50 125,755,317 bp. …”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…Patients and methods The GRACEM study includes patients with non‐metastatic, histologically confirmed, muscle‐infiltrating bladder cancer who underwent RC surgery with curative intent. This study is unique in that the GRACEM Core Team shares decision‐making throughout the pathway, from before the intervention to the end of the patient's follow‐up. …”
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Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy by Saeko Asano, Tatsuhito Himeno, Tomohide Hayami, Mikio Motegi, Rieko Inoue, Hiromi Nakai-Shimoda, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Jiro Nakamura, Hideki Kamiya

“…In this study, we revisited one of those mechanisms, the polyol pathway, and investigated the curative effects of a novel strong aldose reductase inhibitor, ranirestat, in streptozotocin-induced diabetic rats with preexisting polyneuropathy. …”
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O2-self-supplying and glutathione-depleting scaffold for synergistic cancer therapy by Jiajia Zeng, Chongxian He, Xinna Bai, Cijun Shuai, Hao Pan

“…CeO2 also consumes over-expressed GSH through its redox reaction and amplifies the oxidative stress in TME, thus improving the curative effect of PDT. On the other hand, the photothermal effect of scaffold can not only generate heat to kill tumor cells, but also enhance the activity of nanoenzyme, and the catalase activity enhanced by photothermal effect is fed back to PDT, forming a two-way promotion. …”
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Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Computational analysis involved variant calling, curation, and classification using specialized tools and databases. …”
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Death and disappearance: Measuring racial disparities in mortality and life expectancy among people in state prisons, United States 2000-2014. by Bryan L Sykes, Ernest K Chavez, Justin D Strong

“…<h4>Methods</h4>Drawing on a novel dataset created and curated, we calculate standard, age- specific quantities (death rates and life-expectancy) using period lifetable methods, disaggregated by race and sex, across three different periods (2000-2004, 2005-2009, and 2010-2014) for each state. …”
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Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…The hepatic pathology and biochemical indicators of rats were used to judge the modeling results and the curative effect of SQP. Western blotting and qRT–PCR were used to verify the expression of crucial target genes at the protein and RNA levels, respectively. …”
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Correlations between spinopelvic parameters and health-related quality of life in degenerative lumbar scoliosis patients before and after long -level fusion surgery by Jiaqi Zhang, Yinhao Liu, Yan Zeng, Lei Yuan, Weishi Li

“…The objective of this study was to comprehensively assess the correlation between radiographic parameters and HRQoL before and after surgery, and to identified the most valuable spinopelvic parameters for postoperative curative effect. Methods This study retrospectively reviewed 130 consecutive patients who underwent long-level fusion with at least 1 year follow-up. …”
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Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin by Hamad Abdulsalam Hamad Alfarisi, Muhammad Bin Ibrahim, Zenab B. Hamad Mohamed, Nuraniza Azahari, Asmah Hanim Bt. Hamdan, Che Anuar Che Mohamad

“…Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide with no curative therapy. The aim of this study was to investigate the hepatoprotective effects of a novel Trihoney against biochemical and histological manifestations of NAFLD in hypercholesterolemic rabbits. …”
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Case Report of Jingyun Platform's Cognitive Training on Cognitive Impairment with Aphasia by Yu ZHOU, Zhuoming CHEN, Hantian GUAN, Chaoping OUYANG

“…Objective:To observe the curative effect of Jingyun platform's cognitive training on cognitive impairment with aphasia.Methods:A case of cognitive impairment with aphasia was collected, and ABBA model was used to design a case in-subject. …”
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Artrosis: ¿cambios degenerativos o cambios adaptativos? Consejos educativos breves en la consulta de atención primaria by Gema Izquierdo Enríquez, María Victoria García Espinosa, Isabel Prieto Checa, María Fernández de Paúl, Patricia Moreno Carrero, Silvia Fernanda García Vila

“…Moreover, there are no disease-modifying drugs or curative treatment at present; the basic or first-line treatment is non-pharmacological, based on education and physical exercise.The presence of degenerative changes in imaging tests is present in a high percentage of the general asymptomatic population, i.e. in those who have no pain or functional limitation, and this percentage increases progressively with age. …”
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Safeguarding and using global banana diversity: a holistic approach by Ines Van den houwe, Rachel Chase, Julie Sardos, Max Ruas, Els Kempenaers, Valentin Guignon, Sebastien Massart, Sebastien Carpentier, Bart Panis, Mathieu Rouard, Nicolas Roux

“…Collectively, these research activities produce enormous amounts of data that require curation and dissemination to the public. The two information systems at the ITC, Musa Genebank Management System and the Musa Germplasm Information System, serve to manage the genebank activities and to make public germplasm-related data for over 30 banana collections worldwide, respectively. …”
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Network Meta-Analysis of Different Acupuncture Therapies in Treatment of Low Back Myofascitis by GE Haiya, YAN Laijun, YANG Zongrui, SHI Jinyu, ZHAN Hongsheng

“…The probability ranking diagram of intervention measures of each acupuncture therapy showed that the acupoint catgut embedding was the most likely to be the best therapy measure (<italic>P</italic>&lt;0.05).ConclusionThe therapeutic effect of acupuncture therapies on low back myofascitis is better than that of western medication, and acupoint catgut embedding has the best curative effect.…”
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The relationship between psychological stress and mindfulness among outstanding students in the school basic stage by A. A. Alazzam, A. A.K. Al-Shoqran, B. M. Suleiman, M. A. Rababah, B. M. Al-Hawamdeh, I. A.M. Al-Maraziq, I. Tanjour, F. A.M. Al-Habies

“…It also emphasises the need for proactive planning and the implementation of strategies to mitigate psychological stress in students while addressing their developmental and curative needs. The study results can assist researchers and educators in designing educational and counselling programmes catering to outstanding students’ psychological, social and educational needs. …”
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Effect of Respiratory Training on Dysphagia in Children with Cerebral Palsy by Qishan LIU, Haofeng MO, Xiaofang CHEN

“…The degree and grade of dysphagia were assessed by DDS before and after treatment, and the curative effect was assessed by Fujima Ichiro's dysphagia evaluation criteria before and after treatment.Results:There was no significant difference in DDS scores and dysphagia grade between the two groups before treatment(<italic>P</italic>&gt;0.05).After three months of treatment, the DDS scores of two groups showed significant improvement compared with those before treatment(<italic>P</italic>&lt;0.05).The total scores of DDS, oral and pharyngeal stages in the observation group were(5.33±3.08), (4.63±2.23), (0.70±0.78)respectively, which were better than those in the control group(7.20±3.43), (5.58±2.13), (1.81±1.38).The differences were statistically significant(<italic>P</italic>&lt;0.05).The DDS score in oesophagus stage of the observation group was(0.06±0.24)and that of the control group was(0.08±0.28).There was no significant difference between the two groups(<italic>P</italic>&gt;0.05).The DDS scores of children with spastic quadriplegia, involuntary motor type and mixed cerebral palsy before and after treatment in the two groups were significantly improved compared with those before treatment(<italic>P</italic>&lt;0.05).The DDS scores of children with spastic quadriplegia, involuntary motor type and mixed cerebral palsy in the observation group(6.58±2.47), (4.57±2.10)and(4.57±2.59)were better than those in the control group(8.78±3.30), (6.41±2.35), (7.47±3.18), and there were significant differences between the two groups(<italic>P</italic>&lt;0.05).There was no significant difference in the sample size of ataxia and spastic hemiplegia children(<italic>P</italic>&gt;0.05).The degree of dysphagia was improved in the two groups before and after treatment, and the improvement in the observation group was more obvious than that in the control group(<italic>P</italic>&lt;0.05).The total effective rate of the observation group(87.50%)was better than that of the control group(70.83%), and the difference was statistically significant(<italic>P</italic>&lt;0.05).Conclusion:Respiratory training combined with basic swallowing training can significantly improve the symptoms of dysphagia in children with cerebral palsy.…”
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Systematic Evaluation and Trial Sequential Analysis of Therapeutic Effect of Needle Knife <italic>Versus</italic> Acupuncture on Cervical Spondylosis of Cervical Type by HUANG Bowei, CHEN Bin, CHEN Yinzhu, ZHAO Yingrong, ZHAO Hongjia

“…There was no significant difference in the incidence of adverse reactions between the two groups (<italic>P</italic>&gt;0.05).ConclusionCompared with acupuncture therapy, needle-knife therapy has definite curative effect and safety in the treatment of cervical spondylosis of cervical type, which is recommended for clinical application. …”
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Prevalence and factors associated with burnout among healthcare providers at Kasulu district in Kigoma region, 2024: an analytical cross-sectional study in a primary healthcare set... by Omary Ubuguyu, Godbless Henry Mfuru, Khadija I Yahya-Malima

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