Lithological and geochemical characterization of ‘adinole’ artefacts from cave deposits in southwest Wales: A material of choice during the late Middle to Upper Palaeolithic by Richard Bevins, Elizabeth A. Walker, Nick Pearce, Duncan Pirrie, Rob Ixer, Ian Saunders, Matthew Power

“…Further, there is evidence that people were effectively planning for future use or reuse of artefacts, involving curation of tools. The next phase of work will use the lithological characteristics identified here to explore potential sources for the raw material used in the manufacture of these artefacts.…”
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Ophiostomatoid fungi associated with pine bark beetles and infested pines in south-eastern Australia, including Graphilbum ipis-grandicollis sp. nov. by Conrad Trollip, Angus J. Carnegie, Quang Dinh, Jatinder Kaur, David Smith, Ross Mann, Brendan Rodoni, Jacqueline Edwards

“…This not only allowed for robust multi-locus sequence extraction during taxonomic assessment, but also permitted the rapid establishment of a curated genomic database for ophiostomatoid fungi which will continue to aid in the development of improved diagnostic resources and capabilities for Australian biosecurity.…”
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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma by Qianru Li, Qianru Li, Heli Li

“…However, the specific downstream targets and mechanisms by which AhR influences melanoma remain insufficiently understood.MethodsMelanoma samples from The Cancer Genome Atlas (TCGA) and normal skin tissues from the Genotype-Tissue Expression (GTEx) database were analyzed to identify differentially expressed genes, which were intersected with a curated list of AhR-related pathway genes. Prognostic models were subsequently developed, and feature genes were identified. …”
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Prehospital care for ovarian cancer in Catalonia: could we do better in primary care? Retrospective cohort study by Mercè Marzo-Castillejo, Josep M Borras, Carmen Vela-Vallespín, Paula Manchon‐Walsh, Luisa Aliste

“…Objective To assess the impact of prehospital factors (diagnostic pathways, first presentation to healthcare services, intervals, participation in primary care) on 1-year and 5-year survival in people with epithelial ovarian cancer (EOC).Design Retrospective quasi-population-based cohort study.Setting Catalan Integrated Public Healthcare System.Participants People with EOC who underwent surgery with a curative intent in public Catalan hospitals between 1 January 2013 and 31 December 2014.Outcome measures Data from primary and secondary care clinical histories and care processes in the 18 months leading up to confirmation (signs and symptoms at presentation, diagnosis pathways, referrals, diagnosis interval) of the EOC diagnosis (stage, histology type, treatment). …”
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Effect of Intelligent Exercise Training on Lower Limb Rehabilitation in Children with Spastic Cerebral Palsy by Xuemei ZHANG, Meicong ZHANG, Liyang XIA, Yue YANG

“…The TIS scores were (21.75±8.04) and the BBS scores was (45.23±18.23) after treatment in the observation group, which were significantly higher than those of (15.59±4.27) and (25.40±10.65) in the control group (<italic>P</italic>&lt; 0.05).Conclusion:Compared with routine rehabilitation training, intelligent exercise training can significantly improve the exercise capacity and balance ability of children with spastic cerebral palsy, and can improve the muscle tension of the gastrocnemius and adductor children, and increase the stability in the food function. The curative effect is good and suitable for clinical application.…”
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Application Progress of Transcranial Direct Current Stimulation in Rehabilitation of Chronic Low Back Pain by SHI Jian, WAN Ruihan, WANG Yafei, GONG Chen, WANG Yuling

“…This article reviews the current domestic and international research progress of tDCS in CLBP rehabilitation in recent years and discusses the factors that affect its curative effect (e.g., stimulation target, frequency, and synergistic treatment scheme) and possibly effective treatment modes. …”
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Preliminary Clinical Study on Therapy of Lidocaine Local Block Combined with Acupuncture-rehabilitation in Treatment of Post-stroke Upper Limb Spasticity by Ji LI, Li ZHANG, Ying GUAN, Lu WANG, Guile XIN, Yanli XING, Qiang TANG

“…Compared with the control group after treatment, the observation group showed substantial improvements in FMA-UE, MBI, and AROM scores, and the differences were statistically significant(<italic>P</italic>&lt;0.05).Conclusion:Lidocaine local block combined with acupuncture-rehabilitation therapy shows good curative effect with post-stroke upper limb spasticity, as it could effectively reduce spasticity, enhance motor function and daily activity ability, and improve elbow joint activity ability.…”
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Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…<h4>Background</h4>Intestinal transplantation (ITx) represents the only curative option for patients with irreversible intestinal failure. …”
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Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors by Omar Hama Ghalib Azeez Hawramy, Karzan Seerwan Abdullah, Barham M.M. Salih, Qalandar Hussein A. Kasnazani, Dana Taib Gharib, Dara Ahmed Mohammed

“…The aim of the study is to declare the role of surgery in potentially curative malignant pancreatic neuroendocrine tumors, in term of prognosis, survival and complications after the surgical procedures. …”
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The impact of delay in HIV diagnosis on patient survival: analysis of HIV infection trends from 2007 to 2023 by Riyaz A. Shaik, Sharan K. Holyachi, Mohammad S. Ahmad, Mohammed Miraj, Syed Yousaf Kazmi, Mohammad Rehan Asad, Ali Faraz, Mirwais Ramozi, Ritu Kumar Ahmad

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Effect of Hot Compress Therapy with Sizi Powder Combined with Rehabilitation Training for Shoulder-hand Syndrome after Stroke by Mei LI, Lechang ZHAN, Ruihuan PAN, Leying ZHU, Hongxia CHEN

“…Before and after treatment, the visual analog scale(VAS)for pain was used to evaluate the degree of pain, the Fugl-Meyer motor function scale for upper limb(FMA-U)and shoulder mobility were used to evaluate the upper limb function, and the degree of hand swelling was also measured.Results:Before treatment, there was no significant difference in VAS score, FMA-U score, shoulder mobility and hand swelling between the two groups(<italic>P</italic>&gt;0.05).After two weeks treatment, the VAS score, FMA-U score, shoulder mobility and hand swelling of the two groups were improved compared with those before treatment(<italic>P</italic>&lt;0.05), the VAS score and hand swelling in the observation group were(4.06±1.56)and(16.39±1.82)mL respectively, which were better than those(5.33±1.61)and(17.92±2.11)mL respectively in the control group, the differences were statistically significant(<italic>P</italic>&lt;0.05).The FMA-U score of the observation group was(19.91±16.08)and that of the control group was(15.57±15.41), and there was no significant difference between the two groups(<italic>P</italic>&gt;0.05).After treatment, the shoulder flexion was(52.00±40.93)°, the shoulder extension was(20.25±11.85)°, and the shoulder abduction was(48.28±31.95)°in the observation group, and those of the control group were(49.45±41.67)°, (18.22±11.68)°and(45.37±28.19)°respectively, there was no significant difference between the two groups(<italic>P</italic>&gt;0.05).Conclusion:The hot compress therapy with Sizi Powder combined with rehabilitation training can alleviate the pain and reduce the degree of hand swelling in patients with shoulder-hand syndrome after stroke, and the curative effect is better than the simple rehabilitation training.…”
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Leveraging Deep Learning and Multimodal Large Language Models for Near-Miss Detection Using Crowdsourced Videos by Shadi Jaradat, Mohammed Elhenawy, Huthaifa I. Ashqar, Alexander Paz, Richi Nayak

“…We evaluated three deep learning models&#x2014;CNN, Vision Transformers (ViTs), and CNN&#x002B;LSTM&#x2014;on a dataset specifically curated for three-class classification (crashes, near-misses, and normal driving events). …”
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Comparative analysis of deep learning models for crack detection in buildings by S. Siva Rama Krishnan, M. K. Nalla Karuppan, Adil O. Khadidos, Alaa O. Khadidos, Shitharth Selvarajan, Saarthak Tandon, Balamurugan Balusamy

“…In this research, we tackle the research gap and data scarcity by developing and curating a novel deep learning image processing for detecting cracks in brickwork. …”
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Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…Furthermore, the derived differentially expressed genes were curated based on immune functions using functional enrichment analysis to create a protein-protein interaction network. …”
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The Impact of Chronic Pelvic Pain and Bowel Morbidity on Quality of Life in Cervical Cancer Patients Treated With Radio (Chemo) Therapy. A Systematic Literature Review by Natuhwera G, Ellis P

“…Germanus Natuhwera,1,2 Peter Ellis3 1Clinical and Administration Departments, Hospice Africa Uganda, Kampala, Uganda; 2Education Department, Institute of Hospice and Palliative Care in Africa, Kampala, Uganda; 3Canterbury Christ Church University, Canterbury, UKCorrespondence: Germanus Natuhwera, Email ngermans16@gmail.com; gnatuhwera@hospice-africa.orgAbstract: Introduction: Radiotherapy, administered with or without chemotherapy is the gold standard treatment for cervical cancer with both curative and palliative intent. However, the treatments often result in adverse events, mainly chronic pelvic pain and bowel morbidity, which can negatively impact quality of life.Aim: To systematically appraise peer reviewed evidence regarding chronic pelvic pain and bowel morbidity and their impact on quality-of-life of cervical cancer patients treated with radiotherapy with or without chemoradiation therapy.Design: A systematic review of original peer-reviewed research evidence.Data Collection Methods and Tools: A systematic search conducted between April and May 2021, and updated in September 2024, using PubMed, Hinari, CINAHL and Google Scholar, for peer reviewed papers published between 2008 and 2019. …”
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Explainability of Network Intrusion Detection Using Transformers: A Packet-Level Approach by Pahavalan Rajkumardheivanayahi, Ryan Berry, Nicholas U. Costagliola, Lance Fiondella, Nathaniel D. Bastian, Gokhan Kul

“…To facilitate this research, we have curated a comprehensive Packet-level dataset constructed by extracting the network packet captures from two widely used flow-level datasets, namely CIC-IDS2017 and UNSW-NB15. …”
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Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis by Jiahui Jiang, Xiaolei Wang, Tongtong Cheng, Mingyue Han, Xinxin Wu, Haitong Wan, DaojunYu

“…Our study is aimed at exploring the significance of white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), and temperature (T) alone or combined together in early identification and curative effect monitoring of AC with or without sepsis. …”
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Using waist circumference as a predictor of hypertension in Manzese, Dar es Salaam: a community-based cross-sectional study, 2023 by Godbless Henry Mfuru, James N. Allan, Agnes Njau, Omary Ubuguyu, Khadija Y. Malima

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Antimicrobial use in animal farms in Egypt: rates, patterns, and determinants by Nada ElSayed, Amira Amine, Laila El-Attar, Mohamed E. K. Amin

“…Farms were selected from a list curated by a private platform specialized in Egypt’s poultry and cattle industry. …”
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Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…Identifying the host factors, exploring their role in HCV RNA replication, and studying viral effects on their expression is essential for understanding the mechanisms of viral replication and developing novel, effective curative approaches. It is known that the host factors PREB (prolactin regulatory element binding) and PLA2G4C (cytosolic phospholipase A2 gamma) are important for the functioning of the viral replicase complex and the formation of the platforms of HCV genome replication. …”
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