Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer by Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone, Daniela Bonofiglio

“…However, triple-negative breast cancer (TNBC) and metastatic breast cancer disease are primarily treated with chemotherapy, which improves disease-free and overall survival, but does not offer a curative solution for these aggressive forms of breast cancer. …”
Get full text

Delphi study to identify consensus on patient selection for hydrogel rectal spacer use during radiation therapy for prostate cancer in the UK by Amit Bahl, Suneil Jain, Albert Edwards, Rhodri Saunders, Clive Peedell, Heather Ann Payne, James Andrew Thomas, Prantik Das, Amanda Hansson Hedblom, Emily Woodward

“…Objectives To identify consensus on patient prioritisation for rectal hydrogel spacer use during radiation therapy for the treatment of prostate cancer in the UK.Design Delphi study consisting of two rounds of online questionnaires, two virtual advisory board meetings and a final online questionnaire.Setting Radical radiation therapy for localised and locally advanced prostate cancer in the UK.Participants Six leading clinical oncologists and one urologist from across the UK.Interventions Rectal hydrogel spacer.Primary and secondary outcome measures None reported.Results The panel reached consensus on the importance of minimising toxicity for treatments with curative intent and that even low-grade toxicity-related adverse events can significantly impact quality of life. …”
Get full text

In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Mbiantcha Marius, Dawe Amadou, Atsamo Albert Donatien, Ateufack Gilbert, Yousseu Nana William, Khalid Rauf, Mehreen Arif, Fanta Yadang Sabine Adeline, Njoku Isaac Saint, Hamza Dar, Naeem Ur Rehman, Izhar Ahmad

“…This study revealed that Combretin A and Combretin B have anti-inflammatory, antioxidant, and curative properties against colitis experimentally induced by DSS in rats.…”
Get full text

Tuina alleviates the muscle atrophy induced by sciatic nerve injury in rats through regulation of PI3K/Akt signaling by Yingqi Zhang, Hanyu Zhang, Jiayue Liu, Jiawei Sun, Yue Xu, Narentuya Shi, Hongzheng Zhang, Jiawang Yan, Jinping Chen, Hourong Wang, Tianyuan Yu

“…After Tuina intervention, curative effects were evaluated by behavioral assessment, nerve function index, and muscle atrophy index (MAI). …”
Get full text

Prognostic value of tumor‐infiltrating lymphocytes and PD‐L1 expression in esophageal squamous cell carcinoma by Jie Hu, Takeshi Toyozumi, Kentaro Murakami, Satoshi Endo, Yasunori Matsumoto, Ryota Otsuka, Tadashi Shiraishi, Shinichiro Iida, Hiroki Morishita, Tenshi Makiyama, Yuri Nishioka, Masaya Uesato, Koichi Hayano, Akira Nakano, Hisahiro Matsubara

“…Methods Tissue specimens were collected from 126 patients with ESCC who underwent curative esophagectomy. Immunohistochemical analysis and multiplex immunofluorescence for CD4, CD8, CD25, FOXP3, and PD‐L1 in the tumor were used to identify multiple tumor‐infiltrating immune cells (TIIC), Tregs, and TC. …”
Get full text

Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis by Lizheng Wu, Shangwen Jing, Na Li, Dandan Cao, Fangli Pei, Yantong Luo, Xiaoxin Chen, Yingjie Huang, Cheng Zeng

“…Fufukang spray combined with CT had fewer adverse reactions.ConclusionThe addition of CCPPs to CT may acquire a better curative effect in patients with VVC and external does not significantly increase the occurrence of adverse reactions. …”
Get full text

Therapeutic applications of artemisinin in ophthalmic diseases by Hao Sun, Ping Zhao, Lianghui Zhao, Zhizhong Zhao, Haoyu Chen, Cong Ren, Bin Guo

“…It is known for its curative effects in the treatment of pulmonary hypertension, leukemia, diabetes, malaria, and other diseases, owing to its abundant biological activity. …”
Get full text

A multi-stage deep learning network toward multi-classification of polyps in colorectal images by Shilong Chang, Kun Yang, Yucheng Wang, Yufeng Sun, Chaoyi Qi, Wenlong Fan, Ying Zhang, Shuang Liu, Wenshan Gao, Jie Meng, Linyan Xue

“…To train and validate our proposed network, we curated a dataset consisting of 2568 white light endoscopic images. …”
Get full text

Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…Discussion METAPANC is the first international, randomized, controlled, open-label, multicentre, phase III clinical trial for curative intended surgical therapy of oligometastatic pancreatic cancer in Europe and America. …”
Get full text

NON-FUNCTIONING SPORADIC PANCREATIC NEUROENDOCRINE TUMOR IS AN INDEPENDENT RISK FACTOR FOR RECURRENCE AFTER SURGICAL TREATMENT by Estela Regina Ramos Figueira, André Luis Montagnini, Jessica Okubo, Ana Gabriela Vivarelli Fernandes, Marina Alessandra Pereira, Ulysses Ribeiro Junior, Paulo Herman, José Jukemura

“…While surgical resection remains the only curative option, the impact of factors such as tumor grade, size, and type on prognosis and recurrence is still unclear. …”
Get full text

Fluoroscopic Stenting as a Bridge to Surgery versus Emergency Management for Malignant Obstruction of the Colon by Fan Xue, Feng Lin, Jun Zhou, Ning Feng, You-Gang Cui, Xu Zhang, Yu-Peng Yi, Wen-Zhi Liu

“…We retrospectively reviewed 83 patients that were in accordance with inclusion criteria; of these, 33 patients that underwent fluoroscopy-guided SEMS placement followed by elective curative resection were classified as a SEMS group and 50 patients, who received emergency surgery (ES), were classified as an ES group. …”
Get full text

Linking The Cancer Imaging Archive and GenBank to the National Clinical Cohort Collaborative by Ahmad Baghal, Joel Saltz, Tahsin Kurc, Prateek Prasanna, Samantha Baghal, Janos Hajagos, Erich Bremer, Shaymaa Al‐Shukri, Joshua L. Kennedy, Michael Rutherford, Tracy Nolan, Kirk Smith, Christopher G. Chute, Fred Prior

“…Abstract Objective This project demonstrates the feasibility of connecting medical imaging data and features, SARS‐CoV‐2 genome variants, with clinical data in the National Clinical Cohort Collaborative (N3C) repository to accelerate integrative research on detection, diagnosis, and treatment of COVID‐19‐related morbidities. The N3C curated a rich collection of aggregated and de‐identified electronic health records (EHR) data of over 18 million patients, including 7.5 million COVID‐positive patients, seen at hospitals across the United States. …”
Get full text

Worst pattern of invasion: A prognostic indicator in early-stage oral tongue cancer: A single-center cohort study by Bhargav Ram, LM Chandra Sekara Rao S, Daphne Fonseca, Sravan Kumar Ch, Johnathan Gondi, Anil Kumar Akula, Hemantkumar Nemade

“…Materials and methods: We analyzed prospectively collected data of 192 oral squamous cell carcinoma (OSCC) patients treated between 2017 and 2021. Patients underwent curative surgery with or without adjuvant therapy. …”
Get full text

Comparison of metabarcoding taxonomic markers to describe fungal communities in fermented foods by Rué, Olivier, Coton, Monika, Dugat-Bony, Eric, Howell, Kate, Irlinger, Françoise, Legras, Jean-Luc, Loux, Valentin, Michel, Elisa, Mounier, Jérôme, Neuvéglise, Cécile, Sicard, Delphine

“…We created a database, including all mock species sequences for each barcode to compensate for the lack of curated data in available databases. Four bioinformatics tools (DADA2, QIIME, FROGS and a combination of DADA2 and FROGS) were compared. …”
Get full text

Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology by Danny Jazmati, Dennis Sohn, Juliane Hörner-Rieber, Nan Qin, Edwin Bölke, Jan Haussmann, Rudolf Schwarz, Niklas David Niggemeier, Arndt Borkhardt, Florian Babor, Triantafyllia Brozou, Melissa Felek, Balint Tamaskovics, Patrick Melchior, Thomas Beez, Beate Timmermann, Marc Remke, Stefanie Corradini, Rémi Till Schulz, Ronja-Linda Preugschas, Wilfried Budach, Christiane Matuschek

“…Conversely, hypofractionated radiotherapy is not advisable within a curative approach. This study presents significant potential by enabling the estimation of radiobiological fractionations and dose effects in young, vulnerable patients, highlighting its importance for advancing patient-specific therapeutic strategies.…”
Get full text

Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI by Fei Peng, Jiaxiang Xia, Fandong Zhang, Shiyu Lu, Hao Wang, Jiashu Li, Xinmin Liu, Yao Zhong, Jiahuan Guo, Yonghong Duan, Binbin Sui, Chuyang Ye, Yi Ju, Shuai Kang, Yizhou Yu, Xin Feng, Xingquan Zhao, Rui Li, Aihua Liu

“…This study aims to develop a reliable predictive model for assessing intracranial aneurysm (IA) instability by utilizing four-dimensional flow magnetic resonance imaging (4D-Flow MRI) and high-resolution MRI (HR-MRI). Initially, we curated a prospective dataset, dubbed the primary cohort, by aggregating patient data that was consecutively enrolled across two centers from November 2018 to November 2021. …”
Get full text

Final Analysis of Post‐Marketing Surveillance for Avelumab + Axitinib in Patients With Renal Cell Carcinoma in Japan by Norio Nonomura, Taito Ito, Masashi Sato, Makiko Morita, Mie Ogi, Masahiro Kajita, Mototsugu Oya

“…ABSTRACT Introduction Avelumab, an anti‐programmed death ligand 1 antibody, was approved in combination with axitinib for curatively unresectable or metastatic renal cell carcinoma (RCC) in Japan in December 2019. …”
Get full text

Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review by Wai Sinn Soh, Grace L. Burns, Tharindu Senanayake, Raquel Cameron, Kerith Duncanson, Guy D. Eslick, Sharmila S. Prasad, Stephen R. Smith, Simon Keely

“…Despite advances in curative CRC surgery, metastatic disease remains a significant problem. …”
Get full text

Cost-effectiveness and readmission rates of laparoscopic vs. open surgery for colorectal cancer: evidence from the health insurance review and assessment service dataset in South K... by Sanghyun An, Sung Eun Hong, Moo Hyun Kim, Ik Yong Kim

“…IntroductionWe aimed to compare and analyze the cost-effectiveness of laparoscopic vs. open colorectal surgery (CRS) for colorectal cancer using health insurance claims data derived from multiple institutions in South Korea as well as the differences in hospital length of stay (LOS) and 30-day readmission rates related to postoperative complications.MethodsWe retrospectively reviewed the clinical data of patients who underwent curative resection for colorectal cancer between January 1, 2020 and December 31, 2022 using national health insurance claims data in South Korea. …”
Get full text

Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant... by Azadeh Kiumarsi, Amirarsalan Alaei, Mohsen Nikbakht, Saeed Mohammadi, Mohammad Reza Ostad-Ali, Zahra Rasti, Tahereh Rostami

“…BackgroundWith recent advances in clinical practice, including the use of reduced-toxicity conditioning regimens and innovative approaches such as ex vivo TCRαβ/CD19 depletion of haploidentical donor stem cells or post-transplant cyclophosphamide (PTCY), hematopoietic stem cell transplantation (HSCT) has emerged as a curative treatment option for a growing population of patients with inborn errors of immunity (IEI). …”
Get full text