Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence by Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

“…Two C. auris isolates (MMC1 and MMC2) were co-cultured with A. castellanii to examine interaction dynamics, survival, stress responses, growth, virulence, biofilm formation, and antifungal susceptibility. …”
Get full text

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Tau uptake and degradation assays in cultured astrocytes were utilized to investigate the role of HDAC7 on astrocyte-mediated tau clearance. …”
Get full text

Nisin A-producing Lactococcus cremoris formulations for pre- and post-milking teat disinfection modulate the bovine milk microbiota by Alessandra Gazzola, Camilla Ceccarani, Bianca Castiglioni, Filippo Biscarini, Stefano Morandi, Tiziana Silvetti, Renata Piccinini, Milena Brasca, Paola Cremonesi

“…Microbial communities were investigated by cultural and sequence-based methods, and analyzed through bioinformatic and statistical approaches. …”
Get full text

Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…They also disrupted PSC architecture in 3D models in vitro and reduced total tumor and stroma cells in mixed co-cultures. H84T CAR T cells exhibited improved T-cell infiltration in multicellular spheroids and had potent antitumor effects in the xenograft models. …”
Get full text

Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…It was translated into Arabic, culturally adapted, and validated through expert review and pilot testing. …”
Get full text

Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…Methods Human umbilical cord MSCs were cultured under normoxic and hypoxic conditions. Proliferation and related pathways were measured, and RNA sequencing was used to detect changes in the transcriptional profile. …”
Get full text

K-Pop Fandom Activism on Social Media: Refuting Accusations of Slacktivism in Internet Activism by Putri Ananda Saka, Zidan Abdul Jabar Saka, Putri Rahmah Nurhakim, Mirna Yusuf, Yuniar Galuh Larasati, Rabiatul Adawiah

“…Using qualitative research utilizing online sources, this study found that K-Pop fandom activism has enlivened issues that are not only related to their community but have referred to global issues such as social, cultural, environmental and political. This activism is able to become a catalyst on social media in the form of real action rather than slacktivism. …”
Get full text

United by Sports? Key Factors affecting Sports Participation in a Sports-based Initiative to Promote Social Integration in Segregated Communities by Anna Boemmel, Matthias Buser, Thomas Persson

“…Using qualitative content analysis, findings were discussed though the lens of the social integration encompassing four interconnected dimensions (interaction, identification, culturalization, placement) and social capital theory. …”
Get full text

Intensified monsoonal rainstorm events over westerly-dominated Asian interior during the warm mid-Holocene by Peixian Shu, Weijian Zhou, Aaron E. Putnam, Baosheng Li, Shugang Kang, Yingying Sha, Zhengguo Shi, Guodong Ming, Hong Wang, Youbin Sun, David K. Wright, Weiguo Liu, Xiaodong Liu, Peng Cheng, Yougui Song, Dongfeng Niu, John R. Dodson, Hua Du, Jiaju Zhao, Zeke Zhang, Yahui Qiu, Zhisheng An

Get full text

Impact of healthcare-associated infections on in-hospital outcomes during the COVID-19 era: a multicenter comparative study of 20,942 isolated microorganisms from ICU patients by Armin Khavandegar, Zeinab Siami, Aziz Rasouli, Pershang Nazemi, Anoosha Gull

“…Klebsiella species, Acinetobacter species, Escherichia coli, Staphylococcus species, and Pseudomonas aeruginosa were the five most frequent isolated microorganisms, reported in 5,542 (26.50%), 4,171 (19.90%), 2,651 (12.70%), 2,537 (12.10%), and 1,851 (8.80%) cultures, respectively. VAEs were the most common infection types as reported in 3,562 (25%) patients. …”
Get full text

Cloned buffalo bulls and their somatic cell donor bulls exhibit similar in-vitro embryo production efficienc by Tanya Gupta, Gaurav Tripathi, Sonal Gupta, Naresh L. Selokar, Manoj Kumar Singh

“…The presumptive zygotes were cultured in Research Vitro Cleavage medium (RVCL; Cook, Australia) for up to 8 days. …”
Get full text

Application of dynamic systems modeling approach to rank optimal urban waste management strategies using SWOT method by Hamid Shahbandarzadeh, Mohammad Hossein Kabgani

“…Among ST strategies, culturing for recyclable containers weighing 0.51 is in the first place. …”
Get full text

Evaluation of the biological treatment of a real contaminated groundwater through reductive dechlorination biostimulation by Hafsa Yaqoubi, Hafsa Yaqoubi, Geremia Sassetto, Maria Presutti, Mustapha Belfaquir, Bruna Matturro, Bruna Matturro, Simona Rossetti, Laura Lorini, Marco Petrangeli Papini, Marco Zeppilli, Marco Zeppilli

Get full text

Effect of Estradiol-17β Injection on Gonad Development of White Shrimp (Litopenaeus vannamei) by . Tarsim, M. Zairin Junior, E. Riani

“…The females broodstock were cultured for 12 days. The result showed that estradiol-17β had positive effect on gonad development. …”
Get full text

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

“…We also assessed MHC-I expression and presence of CD45+ immune cells in ATG7Δβ-cell islets and evaluated how impaired autophagy affects EndoC-βH1 HLA-I expression under basal and IFNα stimulated conditions. Lastly, we co-cultured ATG7Δβ-cell islet cells with diabetogenic BDC2.5 helper T cells and evaluated T cell activation.ResultsWe found that all ATG7Δβ-cell mice developed diabetes between 11-15 weeks of age. …”
Get full text

Barriers and facilitators to maternal healthcare in East Africa: a systematic review and qualitative synthesis of perspectives from women, their families, healthcare providers, and... by Manaye Yihune Teshale, Agegnehu Bante, Abebe Gedefaw Belete, Rik Crutzen, Mark Spigt, Sarah E. Stutterheim

“…This review identified barriers at various levels: individual barriers included a lack of awareness and knowledge, fear of being treated poorly, and financial constraints; interpersonal barriers comprised limited family support, communication challenges, and a lack of decision-making autonomy; health facility barriers included poor quality of healthcare, poor infrastructure, limited medical supplies, provider shortages, abusive behaviors from healthcare providers, lack of transportation, and high service costs; community-level barriers involved socio-cultural norms, societal stigma, and gender-based disparities; and policy-level barriers included poor focus on maternal health, a lack of male accompaniment policies, and conflicts. …”
Get full text

Provincial distribution and predictors of desire for more children among married and cohabiting women in Sierra Leone by Augustus Osborne

“…Meanwhile, the higher fertility desires among women who use the internet or reside in the northern province point to potential cultural or informational influences, suggesting that targeted communication strategies could address provincial and behavioural variations in fertility preferences. .…”
Get full text

Performance evaluation model of the narrators of Rahian Noor camps. by Abbas Alwardi, Mohammad Mahdi Mohtadi, Mohammadjavad Pahlevanzadeh, Amirhossein Saffarinia, Mohammad Reza Fathi

“…Purpose: During the past years and after the holy defense, one of the biggest cultural events of the country that caused the transfer of experiences and retelling of the historical events and sacrifices of the warriors of Islam during the eight years of the holy defense was Rahian Noor. …”
Get full text

Perspectives of Hispanic and Latinx Community Members on AI-Enabled mHealth Tools: Qualitative Focus Group Study by Stephanie A Kraft, Shaan Chopra, Miriana C Duran, Janet A Rojina, Abril Beretta, Katherine I López, Russell Javan, Benjamin S Wilfond, Margaret Rosenfeld, James Fogarty, Linda K Ko

“…ObjectiveA key step toward developing health technology that is accessible and usable is to understand community member perspectives and needs so that technology is culturally relevant and appropriately contextualized. …”
Get full text

In Vitro Activities of Ceftobiprole and Doripenem Tested against Frequently Encountered Aerobic and Facultative Gram-Positive and Gram-Negative Bacterial Pathogens Isolated from Pa... by James A Karlowsky, Mel DeCorby, Daryl J Hoban, George G Zhanel

“…OBJECTIVES: To determine the in vitro activities of ceftobiprole and doripenem using a collection of frequently isolated aerobic and facultative bacteria cultured from patient blood, urine, respiratory and wound specimens in 12 Canadian hospitals in 2007. …”
Get full text