Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study by Gangping Li, XinJiang Hou, Yuewen Fu, DongJie He, Di Zhang

“…A key limitation is the inability to stratify patients by performance status and lesion number, critical for assessing resective surgery suitability.…”
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Fluorescence Lifetime Imaging of NAD(P)H in Patients’ Lymphocytes: Evaluation of Efficacy of Immunotherapy by Diana V. Yuzhakova, Daria A. Sachkova, Anna V. Izosimova, Konstantin S. Yashin, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev, Artem M. Mozherov, Vladislav I. Shcheslavskiy, Marina V. Shirmanova

“…In this regard, the selection of an appropriate in vitro model and the choice of cellular response assay are critical for reliable predictions. Fluorescence lifetime imaging microscopy (FLIM) is a powerful, non-destructive tool that enables direct monitoring of cellular metabolism on a label-free basis with a potential to resolve metabolic rearrangements in immune cells associated with their reactivity. …”
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A Comparative Spatiotemporal Analysis for Long-Term Trends of Hydrometeorological Variables in Maritsa River Basin by Mehmet Seren Korkmaz, Kevser Merkür Başkesen, Ertuğrul Sunan

“…Revealing long-term trends in hydrometeorological variables plays a critical role in the sustainable management and planning of water resources. …”
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An ecosystem approach to the evaluation and impact analysis of heterogeneous preventive and/or early interventions projects for veterans and first responders in seven countries by S. Lukersmith, L. Salvador-Carulla, C. Woods, T. Niyonsenga, M.R. Gutierrez-Colosia, I. Mohanty, C.R. Garcia-Alonso, D. Diaz-Milanes, J.A. Salinas-Perez, R. Davey, A. Aryani

“…Background: Cumulative exposure to critical incidents and life-threatening events leads to significant risk for Veterans and First Responders (VFRs) developing mental ill health and disorders. …”
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Dentin-Derived Inorganic Minerals Promote the Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells: Potential Applications for Bone Regeneration by Gang Lei, Yanqiu Wang, Yan Yu, Zehan Li, Jiamin Lu, Xingyun Ge, Na Li, Ana Gloria Cuba Manduca, Jinhua Yu

“…Alkaline phosphatase (ALP) activity detection, ALP staining, alizarin red staining, and osteogenic marker expression analysis were performed to investigate the influence of DIM on the osteogenic differentiation of BMMSCs, as well as the relevant signal mechanisms. The model of critical-sized defects in the calvarium of rats was constructed for exploring the in vivo efficiency of DIM on bone regeneration. …”
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Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review by Yaqin Wang, Jiasi Zhang, Dimin Nie, Ai Zhang, Qun Hu, Aiguo Liu

“…These findings underscore the critical role of BRAF alterations as key drivers of oncogenesis in PACC. …”
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Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase by Hyun Gyu Lim, Ye Gao, Kevin Rychel, Cameron Lamoureux, Xuwen A. Lou, Bernhard O. Palsson

“…This study demonstrates how the combination of genome-scale datasets and new data analytics reveals the fundamental characteristics of a key transition in the life cycle of bacteria.IMPORTANCENutrient limitations are critical environmental perturbations in bacterial physiology. …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…Further, we elucidate the critical role of FGF signaling in odontoblast maturation and its biomineralization capacity using the de novo designed FGFR1/2c isoform specific minibinder scaffolded as a C6 oligomer that acts as a pathway agonist. …”
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Risk assessment of fine particulate matter exposure attributed to the presence of the cement industry by A. Mallongi, S. Stang, R.D.P. Astuti, A.U. Rauf, M.F. Natsir

“…This new approach determines the critical factors with major effects on reducing the health risk of the vulnerable population.CONCLUSION: Fine particulate matter poses health risks to adults and children, despite the calculated risks are still acceptable. …”
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Experimental Studies on Shale Cracks and Permeability Evolution Based on Acoustic Emission Monitoring by Hao Chen, Hongkui Ge, Xiaoqiong Wang, Jianbo Wang, Shan Wu

“…Results show that porosity has little influence on the permeability before and after loading, while the propagation and connection of cracks are the most critical factors. As the loading stress increases, the crack volume and sample connectivity both grow. …”
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H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…Endogenously produced hydrogen sulfide (H₂S) is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H₂S levels have proven cardioprotective in models of acute myocardial infarction (MI) and heart failure (HF). …”
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Point prevalence survey of antibiotics in a pediatric tertiary hospital in the Republic of Panama by Ximena Norero, Dora Estripeaut, Elizabeth Castaño, Jacqueline Levy, Paola Lichtenberger, José Pablo Díaz-Madriz, José Luis Bustos, Robin Rojas Cortés, Gabriel Levy-Hara

“…The findings suggest it is necessary to assess the need for ampicillin, gentamicin, and piperacillin-tazobactam use in patients admitted to pediatric critical care units, with special emphasis on children with pneumonia and sepsis diagnosis, the most common pathologies for which an antimicrobial was prescribed.…”
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Sub-ppb H₂S Sensing with Screen-Printed Porous ZnO/SnO₂ Nanocomposite by Mehdi Akbari-Saatlu, Masoumeh Heidari, Claes Mattsson, Renyun Zhang, Göran Thungström

“…The early detection of H₂S is therefore critical for preventing accidents and ensuring compliance with safety regulations. …”
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Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney... by Tazeen Hasan Jafar, Ngiap Chuan Tan, Mihir Gandhi, Sungwon Yoon, Eric Finkelstein, Peter Moey Kirm Seng, Ruiheng Ong, Anandan Gerard Thiagarajah, Bing Long Lee, Ka Chi To, Aminath Shiwaza Moosa

“…Early detection and prompt intervention are critical in preventing progression to end-stage kidney disease (ESKD) and cardiovascular complications. …”
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Robot-assisted upper limb therapy for personalized rehabilitation in children with cerebral palsy: a systematic review by Daniela Cardone, David Perpetuini, Marta Di Nicola, Arcangelo Merla, Giovanni Morone, Giovanni Morone, Irene Ciancarelli, Antimo Moretti, Antimo Moretti, Francesca Gimigliano, Francesca Gimigliano, Alice Cichelli, Francesco De Flaviis, Alex Martino Cinnera, Teresa Paolucci

“…The risk of bias was assessed with the Joanna Briggs Institute critical appraisal tools battery.ResultsOf 756 articles identified, 14 studies involving 193 children with CP with a judged to be of good methodological quality, but with a lack in the study design, were included in the final synthesis. …”
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Trending applications of Phase Change Materials in sustainable thermal engineering: An up-to-date review by Matteo Morciano, Matteo Fasano, Eliodoro Chiavazzo, Luigi Mongibello

“…Through this review, we offer a comprehensive critical analysis of the latest developments in PCMs-based technology and their emerging applications within energy systems. …”
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Risk assessment of look‒alike, sound‒alike (LASA) medication errors in an Italian hospital pharmacy: A model based on the ‘Failure Mode and Effect Analysis’ by Nestor Ciociano, Lucilla Grisi, Lucia Bagnasco, Maria Giovanna Elberti, Marcello Mazzarella

“…The highest ranked failure modes, with an RPN score of 48 pertained to wrong drug dosage selection. Some of the critical failure modes in sample processing (phases n.1, 2, 3, and 4) were improved by 69.7% in the RPN by focusing on automated technology systems. …”
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Seasonal Changes in Climate Variables in Rainfed Crop Areas in the Lerma-Chapala-Santiago Basin, Mexico by Raymundo Ordoñez-Sierra, Miguel A. Gómez-Albores, Carlos Díaz-Delgado, Luis Ricardo Manzano-Solís, Angel Rolando Endara-Agramont, Carlos Alberto Mastachi-Loza

“…Additionally, rainfall showed an annual decrease of approximately 50 mm in all RCAs, which can affect the phenological development of crops during critical stages (emergence through flowering). These changes represent a significant threat to the regional economy and food security of Mexico.…”
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Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…The results demonstrated that the DS increase of the hydrophobic stearic acid segment increased the negative charge, encapsulation efficiency, and drug-loading capacity while decreasing the critical aggregation concentration value as well as the release rate of docetaxel from the nanoparticles. …”
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Harnessing Meta-Reinforcement Learning for Enhanced Tracking in Geofencing Systems by Alireza Famili, Shihua Sun, Tolga Atalay, Angelos Stavrou

“…Effective geofencing relies heavily on precise tracking capabilities, a critical component for maintaining the integrity and functionality of these systems. …”
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