The Gut Microbiota-Related Antihyperglycemic Effect of Metformin by Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska

“…It is critical to sustain the diversity of the microbiota to maintain host homeostasis and health. …”
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Evaluating different drought products for assessing drought and implications on agriculture in Nepal by Shishir Chaulagain, Manoj Lamichhane, Urusha Chaulagain, Sushant Gyawali, Sadina Shrestha, Vishnu Prasad Pandey

“…These insights can inform targeted interventions for winter wheat during their critical growth periods to mitigate drought effects in agriculture.…”
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Research progress of virtual reality technology in the field of stroke rehabilitation (虚拟现实技术在脑卒中康复领域的研究进展) by BIAN Wenjie (边文杰)

“…Rehabilitation training is the most critical way to reduce the disability rate of stroke patients, and it is also a crucial link in the management of stroke. …”
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Unveiling Genital Tuberculosis: India’s hidden Infertility Epidemic by Yashvanthan VR, Angeline Grace G, Sujitha P, Ilam Ilaval T, Hariharan S

“…It also highlights diagnostic and management challenges while proposing strategies to address this critical public health issue. GTB contributes to 15-20% of infertility cases in India, with the highest burden among women aged 20-40 years. …”
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Exploring offshore wind’s potential to enhance energy security in nations with limited land and fuel resources by Kenji Shiraishi, Umed Paliwal, Nikit Abhyankar, Daniel M Kammen, Amol Phadke, Won Young Park

“…Offshore wind (OSW) power is critical to addressing energy security issues in nations with limited land and fuel resources. …”
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Complementary Non‐invasive Fish Monitoring Distinguishes Depth‐Dependent Fish Communities by Ewan Burns, Vijini Mallawaarachchi, Thomas M. Clarke, Belinda Martin, Joseph D. DiBattista, Jamie Hicks, Danny Brock, Elizabeth A. Dinsdale, Charlie Huveneers, Michael P. Doane

“…ABSTRACT Human activities are increasingly affecting marine environments, with fish communities serving as critical indicators of ecosystem health. Effective management of marine fishes is imperative for maintaining the balance of marine ecosystems, necessitating comprehensive monitoring strategies. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…In the cytoplasm, SIRT5 interacted with the scaffold protein JNK-interacting protein 4 (JIP4) to finely regulate MAPK signaling, which was critical for osteoclast differentiation and activation. …”
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Single-channel attention classification algorithm based on robust Kalman filtering and norm-constrained ELM by Jing He, Zijun Huang, Yunde Li, Jiangfeng Shi, Yehang Chen, Chengliang Jiang, Jin Feng

“…This study proposes a robust Kalman filtering method combined with a norm-constrained extreme learning machine (ELM) to address these challenges.MethodsThe proposed method integrates Discrete Wavelet Transformation (DWT) and Independent Component Analysis (ICA) for noise removal, followed by a robust Kalman filter enhanced with convex optimization to preserve critical EEG components. The norm-constrained ELM employs L1/L2 regularization to improve generalization and classification performance. …”
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What’s in it for citizen scientists? An Analysis of Participant Inclusivity in Citizen Science Projects in Advanced Physics Research [version 3; peer review: 1 approved, 2 approved... by Claudia Magdalena Fabian, Elisabeth Unterfrauner, Beatriz Garcia, Gary Hemming

“…As previous work shows, the inclusivity perspective of citizen science projects might be viewed critically as some groups of citizens tend to be overrepresented in these initiatives while others are left out. …”
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Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD by Lijuan Zhou, Jingyi Zhao, Kaile Ma, Rui Hao, Chensi Yao, Xiaowen Gou, Chuanxi Tian, Li Wan, Min Li, Xiaolin Tong

“…Further SCENIC analysis additionally uncovered the essential transcription factors that regulate these cell subclusters, such as Stat2, Mta3, Eomes, and Etv5.ConclusionOverall, our research suggests a promising potential therapeutic agent and identifies critical cell populations and transcription factors that contribute to its therapeutic effects, thereby revealing potential therapeutic targets for NAFLD.…”
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The impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran: an interrupted time series analysis by Siavash Beiranvand, Meysam Behzadifar, Aidin Aryankhesal, Seyed Jafar Ehsanzadeh, Banafshe Darvishi Teli, Masoud Behzadifar

“…Conclusion Our study provides critical insights into the dynamic relationship between the Covid-19 pandemic, patient behavior, and cancer care utilization. …”
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Equipping our public health nutrition workforce to promote planetary health: a case example of tertiary education co-designed with students by Ka Po Chau, Wing Chong, Raquel Londono, Beau Cubillo, Julia McCartan, Liza Barbour

“…Students prioritised the values of ‘collaboration’ and ‘respect’ as being critical to guide personal and professional practice to promote planetary health. …”
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Swine manure management by bokashi fermentation and composting with biological activators in a Colombian High Mountain Region by Patricia Martinez-Nieto, Carlos Abaunza, Gustavo Garcia

“…Conclusion: Bokashi technology complies with Colombia’s environmental regulations for eco-friendly fertilizer production, which allows the sustainable management by-products from swine activities in critical ecological areas such as Forestry Protection Reserves in High Andean ecosystems. …”
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Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii by Fizza Arshad, Asifa Sarfraz, Muhammad Shehroz, Umar Nishan, Asia Perveen, Riaz Ullah, Mohamed A. Ibrahim, Mohibullah Shah

“…Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical importance. In order to find new therapeutic targets and create multiepitope vaccines, this study integrated subtractive proteomics with reverse vaccinology. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. …”
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A 10-Year Risk Assessment and Primary Prevention Study of Atherosclerotic Cardiovascular Disease Among Adult Patients in Saudi Arabia: A Cross-Sectional Study by Abdulhameed Alkhalaf, Qasem Aljabr, Khalid Al Mulla, Duaa Almubarak, Abdul Sattar Khan, Zainab Y. Al Jaziri, Ibrahim Albahrani

“…Modifiable risk factors, including smoking, diabetes, and hypertension, combined with statin and aspirin adherence, highlight critical areas for targeted interventions to reduce the ASCVD burden in this population.…”
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Polymorphism of microsattelite loci within the grape germplasm collection maintained at the Dagestan Experiment Station of VIR by M. M. Agakhanov, V. A. Volkov, P. S. Ulianich, K. M. Abdullaev, E. N. Kislin

“…As for any other large germplasm collections, the problem of genetic identification of the accessions and their originality is critical for the ampelographical collection. Genome of Vitis vinifera L. contains many polymorphic microsatellite loci, their allele diversity could be used to reveal the genetic structure of the ex situ collection as well as for the identification of duplicates. …”
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Life Cycle Assessment of Methanol Production from Municipal Solid Waste: Environmental Comparison with Landfilling and Incineration by Cristiano Queiroz Cerqueira, Electo Eduardo Silva Lora, Lidiane La Picirelli de Souza, Márcio Montagnana Vicente Leme, Regina Mambeli Barros, Osvaldo José Venturini

“…In response, this study addresses a critical question: is methanol production from MSW, a waste-to-chemical (WtC) alternative based on circular economy principles, a more environmentally sustainable approach compared to traditional waste-to-energy (WtE) methods like landfilling with biogas recovery and incineration? …”
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Liquid chromatography-high resolution mass spectrometry based analysis of persistent mobile organic compounds in aqueous samples: Method development and optimization by Kyriaki Anagnostopoulou, Vasileios Alampanos, Eleni Evgenidou, Dimitra A. Lambropoulou

“…Persistent Mobile Organic Compounds (PMOCs) represent a critical threat to water resources due to their high solubility, resistance to degradation, and potential toxicity, posing risks to human health and ecosystems. …”
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Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme by Deniz Ece Özcan, Deniz Köm, Ozan Doğan, Semiha Erişen, Selma Onarici

“…This study highlights the critical role of macerozyme enzymatic pretreatment in overcoming cell wall barriers, enabling effective VIGS applications in somatic suspension cultures. …”
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