CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy by Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng

“…Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). …”
Get full text

Emerging challenges in aquaculture: Current perspectives and human health implications by M. Oghenebrorhie Ruben, A. Bolanle Akinsanola, M. Ekemini Okon, Teslim Shitu, I. Iretomiwa Jagunna

“…Addressing these challenges is critical for ensuring the long-term viability of aquaculture. …”
Get full text

Context makes a difference: a qualitative study exploring how to implement a multifactorial falls prevention intervention in the community by Sara Vandervelde, Bernadette Dierckx de Casterlé, Ellen Vlaeyen, Johan Flamaing, Sien Valy, Goedele Belaen, Koen Milisen

“…However, poor implementation impacts successful outcomes of multifactorial falls prevention interventions. The context is critical to understand variation in implementation and clinical outcomes. …”
Get full text

Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida by Rongchao He, Yanfei Zuo, Qiu Li, Qingpi Yan, Lixing Huang

“…Our findings identified 36 downstream virulence genes regulated by LexA, define three critical LexA binding motifs, and provide an in-depth analysis of LexA's recognition and binding to promoters, thereby regulating virulence gene expression. …”
Get full text

Green synthesis of metal nanoparticles, characterization, and biosensing applications by Chiravoot Pechyen, Benchamaporn Tangnorawich, Surachet Toommee, Robert Marks, Yardnapar Parcharoen

“…The review highlights the vast potential of metal NPs in biosensors, which play a critical role in medical diagnostics, environmental monitoring, and food safety. …”
Get full text

Affective touch enhances low gamma activity during hand proprioceptive perception in children with different neurodevelopmental conditions by Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, José Antonio Mingorance, José Antonio Mingorance, José Antonio Mingorance, Francesc Mestre-Sansó, Vicent Canals, Yannick Bleyenheuft, Pedro Montoya, Pedro Montoya, Inmaculada Riquelme, Inmaculada Riquelme, Inmaculada Riquelme

“…BackgroundGamma wave activity in the sensorimotor cortex is a critical neural mechanism associated with proprioceptive processing, which is essential for motor coordination, balance, and spatial orientation. …”
Get full text

Nanoscale monitoring of the initial stage of water condensation on a printed circuit board by Alekszej Romanenko, Ali Gharaibeh, Bálint Medgyes, Peter Petrik

“…Electrochemical migration is a critical factor contributing to failures in electronics due to humidity. …”
Get full text

A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model by Alison M. Randell, Stephanie Salia, Lucas F. Fowler, Toe Aung, David A. Puts, Ashlyn Swift-Gallant

“…Abstract As the earliest measure of social communication in rodents, ultrasonic vocalizations (USVs) in response to maternal separation are critical in preclinical research on neurodevelopmental disorders (NDDs). …”
Get full text

Assessing groundwater quality and suitability in Qatar: Strategic insights for sustainable water management and environmental protection by Sarra Aloui, Adel Zghibi, Annamaria Mazzoni, Ahmad S. Abushaikha, Adel Elomri

“…These findings highlight the critical importance of groundwater quality indicators for effective monitoring and underscore the need for integrated groundwater management strategies. …”
Get full text

Hungry wintering birds and angry farmers: Crop damage and management implications in a protected wetland in China by Lanyan Zhong, Yanfang Li, Yalong Li, Chuanyin Dai

“…This study highlights the importance of understanding the critical link between wintering birds and farmers in wetland conservation practice.…”
Get full text

Effectiveness of Birthing Ball Exercises Therapy in Improving Labor Pain and Labor Outcomes: A Systematic Review by Uma Phalswal, Sujata Jha, Priyanshi Dixit, Raksha Yadav

“…The aim of this systematic review was to critically evaluate the available evidences on the effect of birthing balls on labor pain and labour outcomes. …”
Get full text

Power flow and power quality improvement of a residential-industrial microgrid using 72-pulse inverter-based UIPC by Mahyar Abasi, Ali Nahavandi, Javad Ebrahimi, Gevork B. Gharehpetian

“…The control design is capable of controlling the active and reactive power of the microgrid in various conditions of normal and critical performance. It also improves the microgrid power quality and the connected power system. …”
Get full text

Impact of Nano-Fuel Additives and Nano-Lubricant Oil Additives on Diesel Engine Performance and Emission Characteristics by Dipakkumar Chimangiri Gosai, Ashishkumar Jashvantlal Modi, Anil Kumar Gillawat

“…Fuel saving and emission control in transportation is a global critical issue, so research is required to concentrate on the energy conservation of diesel engines. …”
Get full text

VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment by Cheng Cheng, Qingrui Zha, Linmao Sun, Tianming Cui, Xinyu Guo, Changjian Xing, Zhengxiang Chen, Changyong Ji, Shuhang Liang, Shengwei Tao, Junhui Chu, Chenghui Wu, Qi Chu, Xuetian Gu, Ning Zhang, Yumin Fu, Shumin Deng, Yitong Zhu, Jiabei Wang, Yao Liu, Lianxin Liu

“…The accumulated G3P diffuses into the TME and directly interacts with SRC-family tyrosine kinase LCK, a critical component of the T-cell receptor (TCR) signaling pathway in CD8+T cells. …”
Get full text

Body donor reperfusion and re-ventilation in medical training: an Italian study testing SimLife® by Irene Neri, Giulio Vara, Antonietta Fazio, Maria Vittoria Marvi, Foteini-Dionysia Koufi, Elisa Boschetti, Simone Lodi, Giulia Adalgisa Mariani, Marilisa Quaranta, Anna Maria Billi, Alessandra Ruggeri, Carlo Barausse, Cyril Brèque, Annalisa Plava, Veronica Moretti, Lucia Manzoli, Stefano Ratti

“…Post-simulation, structured interviews were used to collect data on the interventions performed, participant perceptions of the technology’s usefulness, enjoyment, and willingness to repeat the experience, as well as critical issues encountered.ResultsKey findings include that 86% of participants rated SimLife® technology as extremely useful for post-lauream training, while 84% found it highly beneficial for team-building activities. …”
Get full text

The Role of Additional K-Wires on AO Type C Distal Radius Fracture Treatment with External Fixator in Young Population by Ivan Micic, Erica Kholinne, Yucheng Sun, Jae-Man Kwak, In-Ho Jeon

“…Some surgeons suggested that additional K-wires may play a critical role in the outcome. The purpose of study is to evaluate the role of additional K wires in treating distal radial fracture with external fixator regarding its outcome. …”
Get full text

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy respo... by Benjamin H. Jenkins, Ian Tracy, Maria Fernanda S. D. Rodrigues, Melanie J. L. Smith, Begoña R. Martinez, Mark Edmond, Sangeetha Mahadevan, Anjali Rao, Hailing Zong, Kai Liu, Abhishek Aggarwal, Li Li, Lauri Diehl, Emma V. King, Jamie G. Bates, Christopher J. Hanley, Gareth J. Thomas

“…Abstract Cancer-associated Fibroblasts (CAFs) have emerged as critical regulators of anti-tumour immunity, with both beneficial and detrimental properties that remain poorly characterised. …”
Get full text

Damage evolution of slab tracks with complex temperature distribution by Yang Li, Kailin Cao, Jinjie Chen, Haiyan Li, Zhihao Yang, Guocui Wang

“…Results show that: (1) Considering a vertical nonlinearity of 0.3 and a lateral gradient of 10 ℃/m can improve the maximum vertical displacement by 31.6 %. (2) The critical air temperature for interface damage initiation can be approximately 5 ℃ lower when the vertical nonlinearity and the lateral gradient are not considered than when they are considered. …”
Get full text

EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma by Xianghui Chen, Xiaoyan Wang, Yuxia Zou, Yan Wang, Tingting Duan, Zijie Zhou, Yi Huang, Qing Ye

“…Mechanistically, we identified transferrin receptor (TFRC) as a critical downstream protein. EMC2 interacted with TFRC and promoted its ubiquitin-proteasomal degradation. …”
Get full text

Synergistic impact of temperature and pore saturation on corrosion in carbonated reinforced concrete by Li Soon Wan, Mayuko Hirata, Toshinori Oyamoto, Tetsushi Kanda, Kang Hai Tan

“…This study investigates the temperature-pore saturation relationship through systematic experimental variation (0–40 °C, 60–100 % pore saturation) using electrochemical and non-destructive measurements, aiming to develop accurate predictive tools for RC maintenance in tropical climates. Results revealed a critical phenomenon: minimum pore saturation threshold for severe corrosion decreases significantly with increasing temperature. …”
Get full text