The ENaC taste receptor’s perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis by Wen Li, Wanchao Chen, Di Wu, Zhong Zhang, Peng Liu, Zhengpeng Li, Yan Yang

“…Receptor extracellular arginine, glutamate, aspartate, and lysine residues were the critical amino acid residues recognized to bind salty peptides. …”
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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…This review highlights the developing treatment techniques for modifying cytokine-driven neuroinflammation, focusing on advances that selectively target critical cytokines involved in brain pathology. Novel approaches, including cytokine-specific inhibitors, antibody-based therapeutics, gene- and RNA-based interventions, and sophisticated drug delivery systems like nanoparticles, show promise with respect to lowering neuroinflammation with greater specificity and safety. …”
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Strain rate dependence of dynamic recrystallization and texture evolution in hot compressed Mg-Gd-Er-Zr alloy by Ning Ding, Wenbo Du, Shubo Li, Ke Liu, Xian Du, Zijian Yu

“…The increment of DRX fraction is suggested to result from the reduced DRX critical strain and the increased dislocation density as well as velocity, while the weakened whole texture is attributed to the increased DRX grains. …”
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Esophageal perforation more than 10 years after anterior cervical spine surgery: a case report and literature review by Hua Luo, Zhangfu Wang, Shuang Mi, Wenjun Pan, Xingbing Feng, Zhenghua Hong

“…In cases of late perforation, hardware removal, diverticulum excision and a muscle flap are critical to achieving successful closure of the esophageal lesion, preventing recurrence and ensuring comprehensive repair. …”
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Assessing paramedic performance and background factors in emerging disease outbreak by Karim Javanmardi, Abbas Dadashzadeh, Hossein Feizollahzadeh, Neda Gilani, Mansour Ghafourifard, Javad Dehghannejad

“…Background: Prehospital paramedics played a critical role in the COVID-19 pandemic crisis. Objectives: This study aimed to evaluate paramedic performance and background factors in the outbreak of this emerging disease. …”
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Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats by Pei-Ran Lv, Yang-Shuai Su, Wei He, Xiao-Yu Wang, Hong Shi, Xiao-Ning Zhang, Bing Zhu, Yu Kan, Li-Zhen Chen, Qiao-Feng Wu, Shu-Guang Yu, Xiang-Hong Jing

“…Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. …”
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Analyzing exosomal miRNA profiles in tetralogy of fallot fetuses’ amniotic fluid by Hainan Yang, Yadan Li, Qiuyue Chen, Shangqing Li, Yiru Yang, Guorong Lyu

“…Notably, 25 of these miRNAs were previously reported to be regulated by both Notch and Wnt signaling pathways, which are critical to heart development. Further investigation using mouse embryonal carcinoma P19 cells revealed that miR-10a-5p overexpression inhibited cardiomyogenic differentiation, as evidenced by the suppression of cardiomyocyte marker genes like TBX5. …”
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Object Placement Across Robotics, Image Composition, and XR: A Mixed Reality Framework Proposal by Jalal Safari Bazargani, Abolghasem Sadeghi-Niaraki, Soo-Mi Choi

“…Object placement, a critical task involving the optimal positioning, scaling, and orientation of objects within a given environment, is vital across multiple domains, including robotics, computer vision, and virtual/augmented/mixed reality (VR/AR/MR). …”
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An empirical study on logistic service quality, customer satisfaction, and cross-border repurchase intention by Guan Hui, Abdullah Al Mamun, Mohammad Nurul Hassan Reza, Wan Mohd Hirwani Wan Hussain

“…Domestic e-retailers acknowledge logistics service quality (LSQ) as a critical success factor in business excellence. However, exponential growth in cross-border e-commerce (CBEC) requires a re-evaluation of the relationship between LSQ and consumers repurchase intention. …”
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Archaeological Site Detection: Latest Results from a Deep Learning Based Europe Wide Hillfort Search by Jürgen Landauer, Simon Maddison, Giacomo Fontana, Axel G. Posluschny

“…While automation significantly reduces manual workload, human verification remains critical for refining AI predictions and addressing false positives. …”
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Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes by Cherilyn Uhm, Jianlei Gu, Weina Ju, Stephanie Pizzella, Hande Oktay, Joyce Yao-Chun Peng, Sararose Guariglia, Yong Liu, Hongyu Zhao, Yong Wang, Ramkumar Menon, Nanbert Zhong

“…Our study highlights the critical need to distinguish sPTB subtypes to improve diagnostic precision and therapeutic targeting. …”
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Defect Recognition: Applying Time-Lapse GPR Measurements and Numerical Approaches by Enas Abdelsamei, Diaa Sheishah, Mohamed Aldeep, Csaba Tóth, György Sipos

“…Roads are critical components of infrastructure, and assessing their quality is essential to ensure the safe transport of people and goods, which in turn supports economic prosperity. …”
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A Deep Learning-Based Approach for the Detection of Various Internet of Things Intrusion Attacks Through Optical Networks by Nouman Imtiaz, Abdul Wahid, Syed Zain Ul Abideen, Mian Muhammad Kamal, Nabila Sehito, Salahuddin Khan, Bal S. Virdee, Lida Kouhalvandi, Mohammad Alibakhshikenari

“…The widespread use of the Internet of Things (IoT) has led to significant breakthroughs in various fields but has also exposed critical vulnerabilities to evolving cybersecurity threats. …”
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A qualitative exploration of owner experiences following dog adoption by Bethany Joy Moyer, Helen Zulch, Beth Ann Ventura, Oliver Burman

“…The adjustment period — wherein adopted animals transition to their new home — is a critical time for animal welfare and owner satisfaction, yet literature varies in estimates of how long this period lasts in dogs. …”
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Effect of Future Climate Change on Stratosphere-to-Troposphere-Exchange Driven Ozone in the Northern Hemisphere by Shovan Kumar Sahu, Lei Chen, Song Liu, Jia Xing, Rohit Mathur

“…Abstract Future estimates of atmospheric pollutant concentrations serve as critical information for policy makers to formulate current policy indicators to achieve future targets. …”
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Levistolide A and periplogenin inhibit the growth of gastric cancer cells in vitro and in vivo by Jia Li Guo, Hong Mei Hu, Shao Chin Lee, Ji Zhong Zhao

“…Aim: In the present study, the natural products levistolide A (LA) and periplogenin (PPG) were studied for their growth inhibitory effects on the development of gastric cancer cells in vitro and, more critically, in vivo, alone or in combination with the therapeutic medication 5-fluorouracil (5-FU). …”
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CONCEPTUALIZING ENVIRONMENTAL POLICY: AN ANALYSIS OF RUSSIAN AND INTERNATIONAL LEGISLATION IN THE CONTEXT OF ENSURING ENVIRONMENTAL SECURITY IN THE ARCTIC by Elena M. Klyuchnikova, Vladimir A. Masloboev, Vladimir V. Dyadik, Andrey V. Masloboev, Natalia V. Dyadik, Anastasia N. Chapargina

“…The Arctic has become an area of heightened interest for many nations, with environmental issues in the region remaining a critical subject of discussion. Countries such as China, the EU, and the USA have expressed their interest in shaping the environmental agenda in the Arctic. …”

p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…We evaluated the contribution of L3MBTL4 on proliferation, migration, and phenotype changes of VSMCs and further explored the critical role of p38 and JNK signaling pathway underlying. …”
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Evaluating the Lifelong Learning Approach to Demand-Oriented Research in Student Theses Using the ADDIE Model by Abolghasem Rahmani, Pooria Gill, Siavash Moradi, Atefeh Zabihi Zazoly, Fattane Amuei, adele Rafati

“…They highlighted its key benefits, including enhancing critical thinking, motivating and fostering creativity, and facilitating communication with various institutions within the target market.…”
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Mortality Prediction in the Emergency Service Intensive Care Patients with Possible COVID-19: A Retrospective Cross-Sectional Study by Mehmed Ulu, M. Kaya, Y. Tunc, H. Yildirim, A. Halici, A. Coskun

“… INTRODUCTION: Despite the declining clinical importance of Coronavirus Disease 2019 (COVID-19), the virus is still causes mortality in the critically ill patients. This study aims to determine the impact COVID-19 on mortality, evaluate the performance of Acute Physiology and Chronic Health Evaluation-2 Scores (APACHE II), Sequential Organ Failure Assessment Scores (SOFA) and Pneumonia Severity Index (PSI) for mortality prediction in the COVID-19 suspected patients. …”
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