Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…An oversampling method was applied to balance the data set.Interventions This study has no interventions.Participants The study included 2379 participants, of whom 507 were diagnosed with AD.Primary and secondary outcome measures Including accuracy, precision, recall, F1 score, etc.Results 11 variables were critical in the training phase, including educational level, depression, insomnia, age, Body Mass Index (BMI), medication count, gender, stenting, systolic blood pressure (sbp), neurosis and rapid eye movement. …”
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Recent Developments in Ventricular Assist Device Therapy by Angel Moctezuma-Ramirez, Haseeb Mohammed, Austin Hughes, Abdelmotagaly Elgalad

“…Pediatric ventricular assist devices (VADs) remain a critical unmet need; challenges in developing pediatric VADs include device sizing and managing congenital heart disease. …”
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Evaluation and Optimization Research on the Spatial Distribution of Automated External Defibrillators Based on a Genetic Algorithm: A Case Study of Central Urban District of Nanjin... by Ge Shi, Jiahang Liu, Chuang Chen, Jingran Zhang, Jinghai Xu, Yu Chen, Jiaming Na, Wei Chen

“…Automated external defibrillators (AEDs) are portable emergency medical devices critical for resuscitating individuals experiencing sudden cardiac arrest. …”
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Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering by Ryohei Yamamura, Makoto Kinoshita, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Tomohiro Yata, Keigo Kihara, Daisuke Motooka, Daisuke Motooka, Naoyuki Shiraishi, Yasuko Sugiyama, Shohei Beppu, Hisashi Murata, Naoshi Koizumi, Itsuki Sano, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

“…However, there are no biomarkers that predict relapses associated with steroid tapering; therefore, it is critical to identify potential indicators of disease activity. …”
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Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells by Alessio Cimmino, Magda Gioia, Maria Elisabetta Clementi, Isabella Faraoni, Stefano Marini, Chiara Ciaccio

“…Cancer cells demonstrate remarkable resilience by adapting to oxidative stress and undergoing metabolic reprogramming, making oxidative stress a critical target for cancer therapy. This study explores, for the first time, the redox-dependent anticancer effects of Polydatin (PD), a glucoside derivative of resveratrol, on the human Osteosarcoma (OS) cells SAOS-2 and U2OS. …”
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Thermospheric Neutral Density Variation During the “SpaceX” Storm: Implications From Physics‐Based Whole Geospace Modeling by Dong Lin, Wenbin Wang, Katherine Garcia‐Sage, Jia Yue, Viacheslav Merkin, Joseph M. McInerney, Kevin Pham, Kareem Sorathia

“…A physics‐based, fully coupled geospace model that can accurately resolve the high‐latitude energy input and its variability is critical to modeling the dynamic response of thermospheric neutral density during storm time.…”
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Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy by Shimiao Bu, Shimiao Bu, Jiang-Yue Ling, Jiang-Yue Ling, Xiaojun Wu, Xiaojun Wu, Liting Zhang, Liting Zhang, Xiangyu Shi, Lang Huang, Zheng Zhao, Ying Yang, Zongqin Xiang, Yong U. Liu, Yong U. Liu, Yufeng Liu, Yuehong Zhang, Yuehong Zhang

“…Furthermore, the regulation of T cells by MerTK might represent a critical pathway through which DM evolves into NPDR.…”
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Design of Interface ASIC with Power-Saving Switches for Capacitive Accelerometers by Juncheng Cai, Yongbin Cai, Xiangyu Li, Shanshan Wang, Xiaowei Zhang, Xinpeng Di, Pengjun Wang

“…Closed-loop accelerometers employing switched-capacitor (SC) circuit topologies offer notable advantages, including low power consumption, high signal-to-noise ratio (SNR), and excellent linearity. Addressing the critical demand for high-precision, low-power MEMS accelerometers in modern geophones, this work focuses on the design and implementation of closed-loop interface ASICs (Application-Specific Integrated Circuits). …”
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Experimental Setup and Machine Learning-Based Prediction Model for Electro-Cyclone Filter Efficiency: Filtering of Ship Particulate Matter Emission by Aleksandr Šabanovič, Jonas Matijošius, Dragan Marinković, Aleksandras Chlebnikovas, Donatas Gurauskis, Johannes H. Gutheil, Artūras Kilikevičius

“…These findings underscore the critical need for stringent emission controls, innovative filtration systems, and comprehensive monitoring to mitigate the environmental and health impacts of ship emissions.…”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…These findings indicate that targeted silencing of hepatic PCSK9 significantly reduces lipid levels and effectively mitigates atherosclerosis progression by inhibiting inflammatory responses via the AAV8.P-PCSK9 shRNA vector, thereby providing critical support for its clinical translation.…”
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Epigenetic regulation of banana fruit ripening: global and specific DNA methylation profile, and characterization of DNA methylation-related genes by Dina Hermawaty, Mita Azzahra Putri, Sekar Prabhandiya, Fenny Martha Dwivany, Karlia Meitha

“…Additionally, methylation dynamics were observed on CpG islands of two critical transcription factors, MaMADS1 and MaMADS2, though gene regulation was unaffected. …”
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Optimal selection of diagnostic method for diabetes mellitus using complex bipolar fuzzy dynamic data by Hanan Alolaiyan, Maryam Liaqat, Abdul Razaq, Umer Shuaib, Abdul Wakil Baidar, Qin Xin

“…Precise and reliable decision-making methods are critical for identifying the most effective method of detecting diabetes mellitus. …”
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Risk of Nipah Virus Seroprevalence in Healthcare Workers: A Systematic Review with Meta-Analysis by Matteo Riccò, Antonio Cascio, Claudio Costantino, Silvia Corrado, Ilaria Zanella, Pasquale Gianluca Giuri, Susanna Esposito

“…In this systematic review and meta-analysis, available evidence on NiV infections occurring in healthcare workers (HCWs) was collected and critically appraised. According to the PRISMA statement, four medical databases (PubMed, CINAHL, EMBASE, and Scopus) and the preprint repository medRixv were inquired through a specifically designed searching strategy. …”
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Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons by Valerie Espinal Abreu, Rachel Barnes, Vishnupriya Borra, Jennifer Schurdak, Diego Perez-Tilve

“…AGRP neurons are crucial for energy balance and their increased activity during fasting is critical to promote feeding behavior. The activity of these neurons is influenced by multiple signals including those acting on G-protein coupled receptors (GPCR) activating different intracellular signaling pathways. …”
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Effect of Polymer Network Architecture on Adsorption Kinetics at Liquid–Liquid Interfaces: A Comparison Between Poly(NIPAM-co-AA) Copolymer Microgels and Interpenetrating Network M... by Galina A. Komarova, Elena Yu. Kozhunova, Rustam A. Gumerov, Igor I. Potemkin, Irina R. Nasimova

“…Overall, our findings confirm the efficiency of using PNIPAM-PAA IPN microgels for the preparation of oil-in-water emulsions and their stability, even when the temperature rises above the lower critical solution temperature of PNIPAM.…”
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Between likes and lows: Exploring how social networking, privacy, and loneliness shape college students’ satisfaction by Tarik N. MOHAMED, Rania A. MOURAD, Muhammad AZZEDIN

“…Institutional privacy concerns play a critical mediating role, highlighting the importance of privacy in academic settings. …”
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Prevalence, characteristics, and treatment outcome of congenital malaria in Nigeria: a systematic review by Emmanuel Kokori, Gbolahan Olatunji, Bonaventure Michael Ukoaka, Israel Charles Abraham, Rosemary Komolafe, Victor Oluwatomiwa Ajekiigbe, Ntishor Gabriel Udam, Stanley Eneh, Chidiogo Ezenwoba, Adetola Emmanuel Babalola, Oluwatobi Omoworare, Nicholas Aderinto

“…Quality assessment of included studies was done using the Critical Appraisal Skills Programme (CASP) framework, while a narrative synthesis synthesized and summarized extracted data. …”
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Impact of plasma discharge pressure on implant surface properties and osteoblast activities in vacuum-assisted plasma treatment by Ara Jung, Hyungyu Lee, Heejin Kim, Hyun Jeong Jeon, Sanghoo Park, Bomi Gweon

“…These findings suggest that optimizing gas pressure in plasma devices is critical for effectively controlling excited nitrogen radicals, which improves plasma surface modification and enhances the biocompatibility of implant surfaces.…”
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The influence of sex on sleep characteristics in the adult and older adult population: findings from the EPISONO sleep study by Mayra dos Santos Silva, Priscila Farias Tempaku, Priscila Farias Tempaku, Monica Levy Andersen, Monica Levy Andersen, Sergio Tufik, Sergio Tufik, Dalva Poyares, Dalva Poyares

“…IntroductionSleep is a restorative behavior and is critical for overall health, but differences in sleep patterns between men and women can be seen over the years.AimTo prospectively analyze the polysomnographic findings of adults and older adults who participated in two editions of EPISONO, according to sex.MethodsThe population-based prospective longitudinal study included 688 individuals. …”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…Decisions at the early optimization stage are critical for the success of the drug candidate but are constrained due to the limited knowledge of the antibody and target pharmacology. …”
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