A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyr... by Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

“…This metabolic activation plays a critical role in the development of leukoderma through the production of damage to melanocytes and immunological responses. …”
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Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

“…Delivering scientifically sound information to promote screening of patients with the correct cluster of symptoms and signs would be critical. Materials and Methods. In light of the lack of sound evidence on this issue, expert opinion level of evidence was elicited with the Delphi method. …”
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Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats by Dawood Hossaini, Mohammad Jalal Nazari, Khan Baba Ghazanfar, Mohammad Edris Amiri, Mohammad Tariq Anwary, Mohammad Jawad Jawad, Murtaza Haidary

“…Given the complex neurobiological mechanisms underlying withdrawal symptoms, biotin's ability to modulate critical signaling pathways such as serotonin metabolism, neuroinflammation, and oxidative stress could provide a multifaceted treatment approach.…”
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From botany to bedside: a review of the health benefits of Lycium barbarum as a functional food by Alois Berisha, Elena-Alexandra Alexa, Robbie Kelleher, Tao Zhang

“…This review provides a comprehensive exploration of its botanical characteristics, pharmacokinetics, and safety, alongside a critical evaluation of human clinical studies investigating its therapeutic potential. …”
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Exploring the role of epileptic focus lateralization on facial emotion recognition in the spectrum of mesial temporal lobe epilepsy by Fabio Iannaccone, Chiara Pizzanelli, Francesca Lorenzini, Francesco Turco, Chiara Milano, Claudia Scarpitta, Luca Tommasini, Gloria Tognoni, Riccardo Morganti, Enrica Bonanni, Gabriele Siciliano

“…Earlier onset of MTLE could disrupt the development of FER, possibly interfering during a critical phase of maturation of its circuits, when the focus is right. …”
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Investigation of basalt/kevlar fiber-reinforced porcelain filler infused epoxy composite: A viable alternative for marine applications by Prem Anandh. A, P. Sivabalan, Vinayagam Mohanavel, Thandavamoorthy Raja

“…Water absorption tests indicated minimal moisture uptake (0.6 %) after 48 h of immersion in saltwater, demonstrating excellent resistance to water, a critical property for marine environments. Fatigue testing under 30,000 cyclic loading cycles revealed that the composite retained 55 % of its initial tensile strength, indicating high durability under fluctuating loads. …”
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Clinicopathological risk factors of oral second primary tumours by Jelena Karan, Miriam P. Rosin, Lewei Zhang, Denise M. Laronde

“…Conclusions: Identifying second or multiple oral premalignant lesions is critical for predicting the risk of SPTs regardless of their clinical or histological characteristics. …”
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FSDN-DETR: Enhancing Fuzzy Systems Adapter with DeNoising Anchor Boxes for Transfer Learning in Small Object Detection by Zhijie Li, Jiahui Zhang, Yingjie Zhang, Dawei Yan, Xing Zhang, Marcin Woźniak, Wei Dong

“…The fuzzy Adapter Transformer Encoder utilizes adaptive fuzzy membership functions and rule-based smoothing to preserve critical details, such as edges and textures, while mitigating the loss of fine details in global feature processing. …”
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Diversity, distribution and threat status of Fabaceae plants in Costa Rica: a 135-year herbarium record by Donifer Campos Parra, Andres Blanco Picado, Keilor Rojas Jimenez

“…Additionally, we identified 5 species classified as critically endangered, 29 as endangered, and 21 as near threatened. …”
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Suppressing surface segregation by introducing lanthanides to enhance high-temperature oxygen evolution reaction activity and durability by Jingwei Li, Zichao Wu, Yuxiang Shen, Yuefeng Song, Houfu Lv, Xiaomin Zhang, Guoxiong Wang

“…However, the inferior chemical stability of BSCF results in severe surface segregation and performance degradation under high temperatures. A critical challenge lies in alleviating surface segregation and preserving the high OER performance of BSCF anodes. …”
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Ensemble modeling of the climate-energy nexus for renewable energy generation across multiple US states by Joy Adul, Rohini Kumar, Renee Obringer

“…We analyze data from four key states: California, New York, Florida, and Georgia, and focus on three critical renewable energy sources: hydroelectric, solar, and wind power. …”
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PRMT7: A Pivotal Arginine Methyltransferase in Stem Cells and Development by Bingyuan Wang, Mingrui Zhang, Zhiguo Liu, Yulian Mu, Kui Li

“…Protein arginine methylation is a posttranslational modification catalyzed by protein arginine methyltransferases (PRMTs), which play critical roles in many biological processes. To date, nine PRMT family members, namely, PRMT1, 2, 3, 4, 5, 6, 7, 8, and 9, have been identified in mammals. …”
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The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review by Rita Lih-Ying Shin, Chien-Wei Lee, Oscar Yuan-Jie Shen, Hongtao Xu, Oscar Kuang-Sheng Lee

“…The results may serve as a useful reference for definite success in MSC-based therapy based on the critical interaction with macrophages.…”
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Research on Sulfate Attack Mechanism of Cement Concrete Based on Chemical Thermodynamics by Peng Liu, Ying Chen, Zhiwu Yu, Lingkun Chen, Yongfeng Zheng

“…The orientation of chemical reactions of sulfate attack on cement concrete was theoretically determined as well as the critical sulfate ion concentration and the formation conditions of erosion products. …”
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Separation of Inorganic Forms of Tellurium Using On-Site SPE Followed by ICP-MS or ICP-OES—The Right Solution for Water Monitoring by Katarzyna Kińska, Barbara Żelazko, Olga Gajewska, Magdalena Borowska, Monika Sadowska, Beata Krasnodębska-Ostręga

“…Tellurium, recognized as one of the technology-critical elements, should be considered as a xenobiotic. …”
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Hierarchical Feature Attention Learning Network for Detecting Object and Discriminative Parts in Fine-Grained Visual Classification by A. Yeong Han, Kwang Moo Yi, Kyeong Tae Kim, Jae Young Choi

“…These mechanisms often assume that critical locations have a similar scale and are uniquely localizable, which is not always accurate. …”
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General views on treatment technologies for patients with incisional ventral hernia by E. E. Lukoyanychev, S. G. Izmajlov, V. A. Emelyanov, O. S. Kolchina, A. I. Rotkov, M. N. Kiselyov

“…The choice of allotransplant material and the method of hernia repair are often individual. The value of the critical level of intraabdominal pressure have not been specified, however, all authors agree that its monitoring should become routine. …”
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Association between type of health insurance and dental visits among Ecuadorian older population: evidence from a cross-sectional study by Marite Falquez, Adriana Canessa-Rojas, Antonio Lanata-Flores, Freddy Espinoza-Carrasco, Ivan Cherrez-Ojeda, Karla Robles-Velasco, Marco Faytong-Haro, Claudia Reytor-González, Daniel Simancas-Racines

“…Abstract Background Dental services are often overlooked within healthcare systems, despite their critical role in overall health. Socioeconomic barriers and disparities in insurance coverage frequently limit access to oral care, particularly among vulnerable populations like older adults. …”
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HFIFNet: Hierarchical Feature Interaction Network With Multiscale Fusion for Change Detection by Mingzhi Han, Tao Xu, Qingjie Liu, Xiaohui Yang, Jing Wang, Jiaqi Kong

“…Feature extraction from these targets can result in the loss of critical spatial features, potentially leading to decreased CD performance. …”
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A Machine Learning Approach to Adapt Local Land Use Planning to Climate Change by Julia Forster, Stefan Bindreiter, Birthe Uhlhorn, Verena Radinger-Peer, Alexandra Jiricka-Pürrer

“…This article focuses on a case study of single-family houses in Upper Austria, chosen for its transferability to other regions. It critically reflects on an ML approach, linking data on past and current planning regulations and decisions to the physical environment. …”
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