Epigenetic modifications in bladder cancer: crosstalk between DNA methylation and miRNAs by Wei Li, Wei Li, Wei Li, Peiyue Luo, Peiyue Luo, Peiyue Luo, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Lifeng Gan, Lifeng Gan, Lifeng Gan, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…These modifications not only affect gene expression but also impact critical biological behaviors of tumor cells, including proliferation, differentiation, apoptosis, invasion, and metastasis. …”
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A wide-spectrum mid-infrared electro-optic intensity modulator employing a two-point coupled lithium niobate racetrack resonator by Hyeon Hwang, Kiyoung Ko, Mohamad Reza Nurrahman, Kiwon Moon, Jung Jin Ju, Sang-Wook Han, Hojoong Jung, Min-Kyo Seo, Hansuek Lee

“…The modulator employs a two-point coupling scheme, allowing active control of the coupling strength to maintain critical coupling and thereby ensuring high modulation extinction across a wide spectral region. …”
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Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in Organ-on-a-Chip by Yu-Hsuan Lin, Shing-Fung Lau, Yen-Pei Lu, Kuo-Cheng Huang, Chien-Fang Ding, Yu-Hsiang Tang, Hsin-Yi Tsai

“…We believe that the development of this technology is a critical step toward realizing the concept of “organ twin”.…”
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Regulation of Pear Fruit Quality: A Review Based on Chinese Pear Varieties by Ying Zhang, Yudou Cheng, Yuru Ma, Junfeng Guan, Hao Zhang

“…Enhancing fruit quality has therefore become a critical objective in both fruit production and scientific research. …”
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Ammonium, Nitrate, and Phosphate in Coastal Waters of Red River Biosphere Reserve, Vietnam by Luu Viet Dung, Nguyen Tai Tue, Tran Dang Quy, Mai Trong Nhuan

“…This results emphasize the critical need to reduce nutrient discharge and implement wastewater treatment from anthropogenic activities to safeguard ecosystems and protect the coastal estuary environment. …”
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Analytical criterion to prevent thermal overshoot during dynamic curing of thick composite laminates by Jordi Farjas, José Antonio González, Daniel Sánchez-Rodríguez, Norbert Blanco, Marc Gascons, Josep Costa

“…In this paper, we propose a new analytical model to determine the critical thickness above which thermal runaway occurs when the laminate is heated at a constant rate up to a constant temperature. …”
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Systematic Characterization of the Chemical Components of Canna edulis Ker-Gawl Based on UHPLC Q-Exactive Orbitrap MS Technology by Liqiao Lv, Chi Zhang, Jiahui Wu, Dachuan Zhang, Fangyuan Zhao, Lv Bu Aga, Nan Wang, Junling Li, Leimengyuan Tang, Baosheng Zhao, Chunguo Wang, Xueyong Wang

“…Therefore, rapid and accurate identification and quantification are critical in phytochemical analysis. An efficient approach based on ultrahigh-performance liquid chromatography coupled with Q-Exactive Orbitrap tandem mass spectrometry (UHPLC Q-Exactive Orbitrap MS) was used to analyze the chemical components systematically. …”
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Research on the global trends of COVID-19 associated acute kidney injury: a bibliometric analysis by Wen-jing Zhao, Rui-zhi Tan, Jing Gao, Hongwei Su, Li Wang, Jian Liu

“…Critically ill COVID-19 patients may exhibit various clinical symptoms of renal dysfunction including severe Acute Kidney Injury (AKI). …”
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METTL1 coordinates cutaneous squamous cell carcinoma progression via the m7G modification of the ATF4 mRNA by Xinru Zhang, Tong Chen, Fanrong Zhang, Huanhuan Shi, Xiang Li, Zhijuan Wang, Dong Wang, Chao Hou

“…In conclusion, our results underscore the critical role of METTL1 and m7G modification in cSCC tumorigenesis, suggesting a promising target for future cSCC therapies.…”
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Determination of Crack Resistance of the Cover and Slide Glass by Indentation Method with the Visualization Using Atomic Force Microscopy by V. A. Lapitskaya, T. A. Kuznetsova, S. A. Chizhik

“…Based on the results of crack resistance calculations it was found that critical stress intensity coefficient KIC values are 1.42 MPa∙m1/2 for a glass slide, and 1.10 MPa∙m1/2 for a cover glass.…”
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Evaluating ChatGPT, Gemini and other Large Language Models (LLMs) in orthopaedic diagnostics: A prospective clinical study by Stefano Pagano, Luigi Strumolo, Katrin Michalk, Julia Schiegl, Loreto C. Pulido, Jan Reinhard, Guenther Maderbacher, Tobias Renkawitz, Marie Schuster

“…Nevertheless, the reliance on patient-reported data without direct physician involvement highlights the critical need for medical oversight to ensure diagnostic accuracy. …”
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Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel by Kate Halsby, Gerhard Dobler, Ava Easton, Guntis Karelis, Lenka Krbková, Jan Kyncl, Johann Sellner, Franc Strle, Malin Veje, Joanna Zajkowska, Dace Zavadska, Frederick J. Angulo, Andreas Pilz, Wilhelm Erber, Meghan Gabriel, Jon Russo, Mark Price, Harish Madhava, Uta Katharina Meyding-Lamadé

“…This Delphi panel study found that a critical gap persists in the absence of a feasible and practical classification system for TBEV infection. …”
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RAS, a Pentatricopeptide Repeat Protein, Interacts with OsTRX z to Regulate Chloroplast Gene Transcription and RNA Processing by Zhennan Qiu, Shiyong Wen, Peinan Sun, Dongdong Chen, Chunmiao Wang, Xiliang Song, Liying Xiao, Peiliang Zhang, Dongying Zhao, Cuiping Wen, Peiyan Guan, Xuechu Du, Yinghui Sun, Chenshan Xu, Jian Song

“…Collectively, our findings highlight the critical role of RAS in chloroplast development, as it is involved in RNA processing and the regulation of chloroplast gene expression.…”
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First insights into the spatio-temporal ecology of sympatric large carnivores in Niokolo-Koba National Park, Senegal by Robin Horion, Zoe Woodgate, Marine Drouilly

“…By providing new information on the ecology of large carnivores in West Africa, including where they range and which habitats are critical for their survival, our study will facilitate conservation planning. …”
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NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton by Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho

“…Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. …”
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Tropospheric NO₂: Anthropogenic Influence, Global Trends, Satellite Data, and Machine Learning Application by Valeria Ojeda-Castillo, Mario Alfonso Murillo-Tovar, Leonel Hernández-Mena, Hugo Saldarriaga-Noreña, María Elena Vargas-Amado, Enrique J. Herrera-López, Jesús Díaz

“…Nitrogen dioxide (NO₂) is a critical air pollutant that has significant health and environmental impacts. …”
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A LASSO-derived clinical score to predict severe acute kidney injury in the cardiac surgery recovery unit: a large retrospective cohort study using the MIMIC database by Qi Guo, Jingjing Huang, Yuewei Li, Hongwei Li, Jingfeng Wang, Yong Xie, Tucheng Huang, Wanbing He, Wenyu Lv, Jieping Huang, Yangxin Chen

“…Objectives We aimed to develop an effective tool for predicting severe acute kidney injury (AKI) in patients admitted to the cardiac surgery recovery unit (CSRU).Design A retrospective cohort study.Setting Data were extracted from the Medical Information Mart for Intensive Care (MIMIC)-III database, consisting of critically ill participants between 2001 and 2012 in the USA.Participants A total of 6271 patients admitted to the CSRU were enrolled from the MIMIC-III database.Primary and secondary outcome Stages 2–3 AKI.Result As identified by least absolute shrinkage and selection operator (LASSO) and logistic regression, risk factors for AKI included age, sex, weight, respiratory rate, systolic blood pressure, diastolic blood pressure, central venous pressure, urine output, partial pressure of oxygen, sedative use, furosemide use, atrial fibrillation, congestive heart failure and left heart catheterisation, all of which were used to establish a clinical score. …”
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Porto Alegre Line predicts lenticulostriate arteries encasement and extent of resection in insular gliomas. A preliminary study by Gustavo Rassier Isolan, Gustavo Rassier Isolan, Gustavo Rassier Isolan, Samir Ale Bark, Samir Ale Bark, Jander Moreira Monteiro, Jander Moreira Monteiro, Tobias A. Mattei, Kaan Yağmurlu, Rafaela Fernandes Gonçalves, Rafaela Fernandes Gonçalves, Osvaldo Malafaia, Rafael Roesler, Rafael Roesler, Rafael Roesler, Jurandir Marcondes Ribas Filho

“…The resection limit of tumors placed medially to the Porto Alegre line was intraoperative direct LSTa visualization.ResultsThe LSTa involvement was the most critical medial limiting factor in more aggressive tumor resection and an excellent overall survival (P = 0.022). …”
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OptiBench: An Optical Distance Measurement Test Bench Using Adaptive Algorithm With Sensor Fusion and Environmental Shielding by Kanchana Chathurangi Ahangama, Hemali Pasqual, Chinthaka Premachandra, H. Waruna Haripriya Premachandra

“…It is essential in systems where accuracy and reliability are critical. Environmental factors such as temperature fluctuations, humidity, and light intensity randomly affect the performance of ODM systems. …”
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EMERGENCY DISTANCE EDUCATION AS A SOCIAL COMMUNICATION STRATEGY IN UKRAINE AND THE WORLD by Nadiya Figol, Yuriy Kolisnyk, Tetiana Faichuk, Bogdan Figol

“…Emergency distance learning is characterized as a temporary, urgent transition from traditional forms of education to an online format in emergencies when educational institutions cannot provide the usual learning process. Critical features of EDL are highlighted, such as the rapid implementation, limited time for preparation, and adaptation of educational programs and resources to new conditions. …”
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