Strengthening and toughening an ultra-high strength medium Mn steel by fibrous ferrite bridging mechanism by Chao Zhang, Qian Cheng, Bo Yang, Wuli Su, Xue Chen, Qingyuan Wang, Wenquan Cao, Chongxiang Huang

“…Achieving exceptional strength and ductility is a critical requirement for most materials. In this work, an ultra-strong medium Mn steel with hard martensite as the matrix and a large number of uniformly distributed long and coarse soft fibrous ferrites embedded within it had been designed. …”
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The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K by Adel Noubigh, Abdalazeem A. Omar, Manef Abderrabba

“…This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. …”
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Recombinant AAV batch profiling by nanopore sequencing elucidates product-related DNA impurities and vector genome length distribution by Florian Dunker-Seidler, Kathrin Breunig, Magdalena Haubner, Florian Sonntag, Markus Hörer, Rebecca C. Feiner

“…Our data highlight a high vector batch quality with low plasmid-derived and host cell DNA impurities of random origin, critical for mitigating associated safety risks. Finally, we compared nanopore data with orthogonal SMRT sequencing data and observed a higher base quality, but largely similar length and impurity profiles. …”
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TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques... by Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng

“…Thus, this study illustrated that TEAD1 played a critical role in promoting the trans‐differentiation of VSMCs into fibroblast‐like cells and subsequent extracellular matrix production through the Wnt4/β‐Catenin pathway. …”
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Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus by Weiwei Ma, Chenyang Ren, Lin Shi, Bo Meng, Yali Feng, Ying Zhang

“…We also found that the HA-T137I substitution was critical for α2,6-linked sialic acid binding preference and HA activation and stability of H9N2 virus. …”
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Nootkatone Derivative Nootkatone-(E)-2-iodobenzoyl hydrazone Promotes Megakaryocytic Differentiation in Erythroleukemia by Targeting JAK2 and Enhancing JAK2/STAT3 and PKCδ/MAPK Cro... by Yang Pan, Feng Xiao, Chaolan Pan, Hui Song, Peng Zhao, Meijun Chen, Liejun Huang, Jue Yang, Xiaojiang Hao

“…Network pharmacology and experimental validation confirmed that N2 targeted JAK2, and knockdown of JAK2 abolished N2-induced megakaryocytic differentiation, underscoring JAK2’s critical role in erythroleukemia differentiation. In conclusion, N2 shows great promise as a differentiation therapy for erythroleukemia, offering a novel approach by targeting JAK2-mediated signaling pathways to induce megakaryocytic differentiation.…”
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Depositional environment of shallow-marine arenites in the Northern Apennines (Italy) affects aquifer performance: an interpretive key to groundwater management in a climate change... by Maria Filippini, Alessandro Amorosi, Enrico Dinelli, Stefano Segadelli, Laura Landi, Tommaso Casati, Alessandro Gargini

“…New Hydrological Insights for the Region: this study emphasizes the critical role of depositional environments in shaping the aquifer characteristics of the Pantano Formation. …”
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Targeting tRNA‐Derived Non‐Coding RNA Alleviates Diabetes‐Induced Visual Impairment through Protecting Retinal Neurovascular Unit by Jin Yao, Wen Yao, Jun‐Ya Zhu, Yan Liu, Jin‐Hong Liu, Yu‐Ke Ji, Xi‐Shen Ni, Wan Mu, Biao Yan

“…Abstract Diabetes is a major risk factor for compromised visual health, leading to retinal vasculopathy and neuropathy, both of which are hallmarks of neurovascular unit dysfunction. Despite the critical impact of diabetic retinopathy, the precise mechanism underlying neurovascular coupling and effective strategies to suppress neurovascular dysfunction remain unclear. …”
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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release by Shengnan Zhao, Zizhen Gong, Xixi Du, Chunyan Tian, Lingyu Wang, Jiefei Zhou, Congfeng Xu, Yingwei Chen, Wei Cai, Jin Wu

“…Therefore, our findings suggest that S1PR2/ERK1/2/cathepsin B signaling plays a critical role in triggering inflammasome activation by DCA and S1PR2 may represent a new potential therapeutic target for the management of intestinal inflammation in individuals on a high-fat diet.…”
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Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage by Hongya Zhang, Xiaohui Li, Jing Bai, Cong Zhang

“…Background NOP2/Sun RNA methyltransferase 5 (NSUN5) is an RNA methyltransferase that has a broad distribution and plays critical roles in various biological processes. However, our knowledge of the biological functions of NSUN5 in mammals is very limited. …”
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The chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice by Kangxi Du, Jiabing Wu, Jiachen Wang, Wenhao Xie, Liufan Yin, Xiang Li, Chao Li, Aiwu Dong

“…Abstract The INO80 chromatin remodeling complex plays a critical role in shaping the dynamic chromatin environment. …”
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Challenges in safe environmental applications of biochar: identifying risks and unintended consequence by Mingying Dong, Mengyuan Jiang, Lizhi He, Zirun Zhang, Williamson Gustave, Meththika Vithanage, Nabeel Khan Niazi, Bo Chen, Xiaokai Zhang, Hailong Wang, Feng He

“…While most research has focused on the benefits of biochar application in soil enhancement, water quality improvement, and climate change mitigation, the potential risks associated with its use have often been overlooked. This oversight is critical, as the environmental fate of biochar is contingent upon understanding these risks. …”
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Long Time Series Spatiotemporal Variations in NPP Based on the CASA Model in the Eco-Urban Agglomeration Around Poyang Lake, China by Tianmeng Du, Fei Yang, Jun Li, Chengye Zhang, Kuankuan Cui, Junxi Zheng

“…The ecological urban agglomeration around Poyang Lake represents a critical development area in the Yangtze River basin. …”
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Research on Cold-Energy Loss of Long-Distance Sleeve-Type Insulated Pipe for High-Temperature Deep Mines by Lijuan Zhang, Wenlong Wang, Fengtian Yue, Jingsheng Wei, Tao Gao, Yangjie Wang, Yang Zhou

“…As mining operations extend to greater depths, they encounter critical challenges, including increased distances and substantial energy losses. …”
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A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells by Anna Babin-Ebell Gonçalves, Yifang Mao, Tinja Baljkas, Felix Wiedmann, Larissa Eis, Franziska Pilz, Manuel Winkler, Sina W. Kürschner-Zacharias, Marlene Hoffarth, Charlotta Funaya, Réza Shahidi, Cyrill Géraud, Chi-Chung Wu, Constanze Schmidt, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Mahak Singhal

“…Abstract Liver sinusoidal endothelial cells (LSECs) critically regulate homeostatic liver function and liver pathogenesis. …”
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Network Digital Twin Toward Networking, Telecommunications, and Traffic Engineering: A Survey by Reza Poorzare, Dimitris N. Kanellopoulos, Varun Kumar Sharma, Poulami Dalapati, Oliver P. Waldhorst

“…Telecommunications, along with traffic engineering as one of its critical components, play a prominent role across various networking domains, including Internet service providers, data centers, cellular networks, intelligent transportation systems, and smart cities. …”
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The Implementation of Diverse Actuation System in ACPR1000 Nuclear Power Plants by Zhen-Ying Wang, Zhi-Yun Liu, Ting-Wei Ma, Chen Sun, Liu Liu, Yu Huang, Gang-Miao Guo

“…Insight into probabilistic safety assessment proves significant reductions of risks are contributed. The critical technical issues while implementing DAS, such as measures to ensure its diversity from RPMS, precautions for preventing from its spurious actuation, isolation and independency from RPMS, and its testability and maintainability, are deliberately settled to improve its engineering reliability and alleviate the impact on RPMS as far as possible. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Conclusions:</b> The OCA lips@Apt nanodrug demonstrated superior therapeutic efficacy with minimal off-target effects, offering a promising strategy to overcome critical barriers in liver fibrosis treatment. By precisely targeting the fibrotic ECM and modulating key pathological pathways, this TnC-guided liposomal delivery system provides a significant advancement in antifibrotic nanomedicine.…”
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Harnessing AI for sustainable higher education: ethical considerations, operational efficiency, and future directions by Sunawar Khan, Tehseen Mazhar, Tariq Shahzad, Muhammad Amir Khan, Ateeq Ur Rehman, Mamoon M. Saeed, Habib Hamam

“…The prospects and difficulties of AI in higher education are critically examined, including its potential to change traditional educational roles, improve academic performance, and maintain institutional profitability. …”
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Possible Superconductivity Transition in Nitrogen‐Doped Lutetium Hydride Observed at Megabar Pressure by Xingbin Zhao, Yu Huang, Shuailing Ma, Hao Song, Yanwei Cao, Hao Jiang, Yanping Huang, Tian Cui

“…Resistivity measurements in the Fm3¯m‐LuH3±xNy phase under varying magnetic fields exhibited characteristics consistent with superconductivity, with an upper critical field μ0Hc2(0) of 3.3 T measured at 163 GPa. …”
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