Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. …”
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Digitalisation to zero-waste: the interplay of open eco-innovation and the circular economy in agricultural enterprises by Wutthiya Aekthanate Srisathan, Wongsatorn Worrakittikul, Kanokon Rattanapon, Thippayarat Hongto, Apichai Phrommasakha Na Sakhonnakon, Phaninee Naruetharadhol

“…The findings highlight the critical role of innovative digital practices in promoting sustainable ecosystems and addressing the urgent need for near-zero-waste strategies in agriculture. …”
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Proximate values and elemental analysis in wheat and soybean using inductively coupled plasma mass spectrometry by G. Kowmudi, V. Rashmi, K. Anoop, N. Krishnaveni, S. Naveen

“…BACKGROUND AND OBJECTIVES: Determining food composition and bioactivity is critical to both theoretical and applied research in food science and technology. …”
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Rating pome fruit quality traits using deep learning and image processing by Nhan H. Nguyen, Joseph Michaud, Rene Mogollon, Huiting Zhang, Heidi Hargarten, Rachel Leisso, Carolina A. Torres, Loren Honaas, Stephen Ficklin

“…Moreover, while these visual assessments are critical empirical data, they are often coarse‐grained and lack consistent objective criteria. …”
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Remote sensing-based winter wheat yield estimation integrating machine learning and crop growth multi-scenario simulations by Xin Du, Jiong Zhu, Jingyuan Xu, Qiangzi Li, Zui Tao, Yuan Zhang, Hongyan Wang, Haoxuan Hu

“…Accurate and timely winter wheat yield prediction is critical for effective agricultural management and food security. …”
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Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts by Emanuela Mrak, Lavinia Casati, Francesca Pagani, Alessandro Rubinacci, Guido Zarattini, Valeria Sibilia

“…Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis, we investigated its involvement in mediating ghrelin effects in osteoblasts and in osteoblast-osteoclast cross talk. …”
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Does forest loss and fragmentation reduce woodpecker-associated ecosystem functions? by Kazuma Yasuda, Daiki Kato, Shoji Naoe, Tatsuya Amano, Tetsuro Yoshikawa, Kahoko Tochigi, Shinsuke Koike

“…Woodpeckers inhabiting large trees are particularly susceptible to forest loss and fragmentation. They play a critical role in the ecosystem, as they not only create tree cavities, but might also contribute to the number of tree falls. …”
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PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation by Yidong Zhang, Hang Xu, Xuedan Han, Qiyi Yu, Lufeng Zheng, Hua Xiao

“…The model was used to classify clinical subtypes of breast cancer, and PMAIP1 was identified as a potential critical gene related to glucose metabolism in breast cancer. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. …”
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Integrating attention mechanism and boundary detection for building segmentation from remote sensing images by Ping Liu, Yu Gao, Xiangtian Zheng, Hesong Wang, Yimeng Zhao, Xinru Wu, Zehao Lu, Zhichuan Yue, Yuting Xie, Shufeng Hao

“…Accurate building segmentation has become critical in various fields such as urban management, urban planning, mapping, and navigation. …”
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Impact of heat stress on growth and physiological parameters of soybean varieties at the seedling stage by Bashir Hassan, Samanhudi, Parjanto, Setyawati Andriyana, Komariah, Senge Masateru, Rahayu Muji, Salma Fathin Tilmiidzah

“…While all varieties showed optimal growth at 25°C, increasing temperatures from 25 to 30°C led to an increase in growth. A critical threshold was observed between 35 and 40°C, where most varieties experienced a sharp performance decline. …”
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Evaluation of the Influence of Sensor Geometry and Physical Parameters on Impedance-Based Structural Health Monitoring by L.V. Palomino, K.M. Tsuruta, J.R.V. Mour Jr, D.A. Radea, V. Steffen Jr., D.J. Inman

“…The environmental influences become more critical under certain circumstances, especially in aerospace applications, in which extreme conditions are frequently encountered. …”
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Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice by Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida

“…MD simulation of Drp1 structure and site-directed mutagenetic analysis reveal a functional interaction between Cys644 and a critical phosphorylation site Ser637, through Glu640. …”
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Development and Characterization of Lyophilized Chondroitin Sulfate-Loaded Solid Lipid Nanoparticles: Encapsulation Efficiency and Stability by Marta E. Bustos Araya, Anna Nardi Ricart, Ana C. Calpena Campmany, Rafel Prohens, Montserrat Miñarro Carmona

“…Two formulations (SLN-1 and SLN-2) were produced and optimized by evaluating critical physicochemical properties such as particle size, zeta potential, encapsulation efficiency (EE%), and stability. …”
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Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer by Minhua Deng, Zhaohui Zhou, Jiawei Chen, Xiangdong Li, Zefu Liu, Jingwei Ye, Wensu Wei, Ning Wang, Yulu Peng, Xin Luo, Lijuan Jiang, Fangjian Zhou, Xianchong Zheng, Zhuowei Liu

“…Abstract Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. …”
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Applicability of the decomposed theory of planned behavior for the evaluation of community-dwelling older adults’ acceptance in continuous usage of robot-assisted board games for c... by Chiu-Mieh Huang, Su-Fei Huang, Yu-Ting Chen, Ching-Hao Chang, Hsiu-Chun Chien, Ying-Jie Chang, Kuei-Yu Huang, Jong-Long Guo

“…Perceived usefulness positively affected attitude and continuous usage intention, indicating that perceived usefulness is critical in promoting older adults’ continuous usage intention. …”
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Nurture-U student mental health longitudinal survey: a study protocol by Kate E Saunders, Samuel R Chamberlain, Jemima Dooley, Edward R Watkins, Liz Forty, Sarah Rees, Anne C Duffy, Anthony Quinn, Ellen Marshall, Lucy Dorey, Kevin A Matlock, Alexandra Newbold, Lucy J Robinson

“…Introduction University life represents a critical period for young adults, providing opportunities for personal growth and development of coping skills but also posing significant mental health challenges. …”
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Social support from different sources and its relationship with stress in spaceflight analog environments by Suzanne T. Bell, Steven R. Anderson, Peter G. Roma, Lauren Blackwell Landon, Sheena I. Dev

“…Our results are important as they: (a) empirically document the decline in perceived social support over time in extended isolation; (b) provide evidence for the critical importance of the role of fellow crewmembers in being able to provide social support in conditions of extended isolation and communication delay; and (c) underscore the need to more fully understand the dynamics between the crew and external sources of social support (public, organization, family/friends/colleagues) as well as how those relationships may be best supported for individuals who live and work in long-term isolation and confinement.…”
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High‐Performance Pure Water‐Fed Anion Exchange Membrane Water Electrolysis with Patterned Membrane via Mechanical Stress and Hydration‐Mediated Patterning Technique by Yeonjae Lee, Sungjun Kim, Yoseph Shin, Yeram Shin, Seongmin Shin, Sanghyeok Lee, Minseop So, Tae‐Ho Kim, Sehkyu Park, Jang Yong Lee, Segeun Jang

“…Abstract Despite rapid advancements in anion exchange membrane water electrolysis (AEMWE) technology, achieving pure water‐fed AEMWE remains critical for system simplification and cost reduction. …”
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Recent advances in metal-organic frameworks for electrochemical sensing applications by Magesh Kumar Muthukumaran, Muthukumar Govindaraj, Sakthivel Kogularasu, Balasubramanian Sriram, Bharathi Kannan Raja, Sea-Fue Wang, Guo-Ping Chang-Chien, Arockia Selvi J

“…., supercapacitors, batteries, and water-splitting catalysts) and in the fabrication of high-performance electrochemical sensors. This review critically examines the electrochemical properties of MOF-based materials for detecting various analytes, exploring their current limitations and potential for improvement. …”
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