Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in breast cancer by Xiaozhou Yang, Xiaojun Yang, Haili Tang, Xin Chen, Jiangang Wang, Huadong Zhao

“…However, the relationship between CSCs and the tumor microenvironment in BRCA individuals remains unknown, and this information is critically needed. Our research utilized bioinformatics techniques and TCGA data to explore the complex relationship between CSCs and BRCA development. …”
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Development of a prognostic gene signature and exploration of P4HA1 in the modulation of cuproptosis in colorectal cancer by RenJie Jiang, LinLin Ruan, Taohui Ding, Hongtao Wan, Yanglin Chen, XiaoJian Zhu, Zhijiang Huang, Dengke Yao, Ming Li, Bo Yi, Dan Liu

“…Key genes were further refined through LASSO regression and random forest approaches, culminating in the development of a prognostic model comprising six critical genes. The predictive accuracy of the model was validated using two independent external datasets. …”
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POMA-C: A Framework for Solving the Problem of Precise Anesthesia Control Under Incomplete Observation Environment in Low-Income Areas by Yide Yu, Huijie Li, Dennis Wong, Anmin Hu, Jian Huo, Yan Ma, Yue Liu

“…This paper introduces the POMA-C (Partial Observable Model for Anesthesia Control) framework, developed to address the challenge of anesthesia management in environments with incomplete physiological monitoring, such as low-resource settings where critical indicators like the Bispectral Index (BIS) are often unavailable. …”
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Decoding TDP-43: the molecular chameleon of neurodegenerative diseases by Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao

“…Abstract TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction implicated in a wide spectrum of diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD). …”
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Reimagining Global Health: Accelerating Change for a Sustainable Future by Melissa Salm, Ala Alwan, Maureen Lichtveld, Patricia J. García, Peter H. Kilmarx, Nelson K. Sewankambo, Rebecca Martin, Tahmeed Ahmed, Judith N. Wasserheit

“…Such an assessment is also critical for progress in promoting equity, including decolonizing global health. …”
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Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles by Majid Moussaei, Ebrahim Tajik, Vahid Haddadi-Asl, S. Ali Mazloumi, Helia Heydarinasab, Elahe Abdollahi, Fatemeh Haj-Sadeghi, Hanie Ahmadi, Mohammad Reza Gholizadeh

“…Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. …”
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Improving the Reporting of Primary Care Research: Consensus Reporting Items for Studies in Primary Care—the CRISP Statement by Phillips William R., Sturgiss Elizabeth, Glasziou Paul, olde Hartman Tim C., Orkin Aaron M., Prathivadi Pallavi, Reeve Joanne, Russell Grant M., van Weel Chris

“…Improved reporting of the context of the clinical services and the process of research is critical to interpreting study findings/results and applying them to diverse populations and varied settings in PC.…”
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Comparison of Resampling Methods and Radiomic Machine Learning Classifiers for Predicting Bone Quality Using Dual-Energy X-Ray Absorptiometry by Mailen Gonzalez, José Manuel Fuertes García, María Belén Zanchetta, Rubén Abdala, José María Massa

“…This comprehensive approach, which addresses the critical aspects of the problem, distinguishes this work from previous studies, improving the performance achieved by the most similar studies. …”
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Anatomical alterations: biparietal thinning in antiquity. Review of published cases and a new case by Nicol Rossetti, Roberta Fusco, Arianna Vanni, Francesca Garanzini, Alessandra Mazzucchi, Marta Licata

“…Cranial anatomical variations, such as biparietal thinning, offer critical insights into the health and living conditions of ancient populations. …”
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Maximizing zearalenone removal: Unveiling the superior efficiency of pre-treated carbon in adsorption and photocatalysis by J.C. Gómez-Vilchis, G. García-Rosales, L.C. Longoria-Gándara, E.O. Pérez-Gómez, D. Tenorio-Castilleros

“…Photodegradation results showed removal efficiencies of 95 ± 0.68 % for BC and 98 ± 0.36 % for BCA, highlighting the critical role of light intensity in ZEN degradation. …”
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How Speech–Language Pathologists Adapt This Is Me Digital Transition Portfolios to Support Individuals with Intellectual/Developmental Disabilities and Communication Challenges Acr... by Eve Müller, Jamie R. Kleiner, Danielle Evans, Ann Kern, Dawn Reikowsky, Katherine Smidl

“…Critical information is frequently lost when individuals with intellectual/developmental disabilities (I/DD) and co-occurring communication challenges transition from one educational/clinical setting to another. …”
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Elevated FOXC1 emerged as a critical element, promoting the transcription of serine metabolism enzymes PHGDH, PSAT1, and PSPH, which in turn facilitated serine production, supporting CRC growth. …”
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Infiltration-driven performance enhancement of poly-crystalline cathodes in all-solid-state batteries by Junghwan Sung, Junyoung Heo, Dong-Hee Kim, Hawon Gu, Yung-Soo Jo, Heetaek Park, Jun-Ho Park, Jeong-Hee Choi, Yoon-Cheol Ha, Doohun Kim, Jun-Woo Park

“…The result from this study confirmed the critical influence of interface engineering and material morphology on the overall performance and stability of ASSBs and could facilitate the development of high-performance ASSBs in the future.…”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. …”
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Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits by Hamid Mushtaq, Simona Piccolella, Jose A. Mendiola, Lidia Montero, Elena Ibáñez, Severina Pacifico

“…Sustainable agro-waste revaluation is critical to enhance the profitability and environmental footprint of the olive oil industry. …”
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Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2′-5′ oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. …”
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Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…In an effort to elucidate important mechanisms that may play a critical role in the progression to overt disease, we propose a mathematical model that takes into account the dynamics of functional and dysfunctional $\beta$-cells, regulatory T cells, and pathogenic T cells. …”
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Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury: A Report of Three Cases in Which Surgeries Were Performed at Different Timings by Yohei Kawatani, Hirotsugu Kurobe, Yoshitsugu Nakamura, Yuji Suda, Takaki Hori

“…Blunt thoracic aortic injury (BTAI) is a critical condition. Thoracic endovascular aortic repair (TEVAR) is considered a surgical treatment for BTAI. …”
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The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature by Silvia Ciraolo, Agnieszka Kulczycka-Rowicka, Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec

“…While several mechanisms have been proposed, further research is necessary to rule which are most critical. The benefits observed with SGLT2 inhibitors stress their potential as a cornerstone in HF management, regardless of a patient’s diabetes status.       …”
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Ensuring Africa’s Food Security by 2050: The Role of Population Growth, Climate-Resilient Strategies, and Putative Pathways to Resilience by Belay Simane, Thandi Kapwata, Natasha Naidoo, Guéladio Cissé, Caradee Y. Wright, Kiros Berhane

“…Climate change is a critical factor in Africa’s food systems, with an average temperature increase of approximately +0.3 °C per decade. …”
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