Key elements for designing effective second victim support interventions: a focus group study in European clinical settings by José Joaquín Mira, Irene Carrillo, Kris Vanhaecht, Deborah Seys, Massimiliano Panella, Susanna Tella, Katja Schrøder, Reinhard Strametz, Paulo Sousa, Bojana Knezevic, Kaja Pölluste, Eva Gil-Hernández, Hana Knežević Krajina, Sofia Guerra Paiva, Einav Srulovici

“…Analysis of common elements considered key to the success of these programmes was underscored.Results Critical success factors for designing effective SV support interventions included the need for an occupational health approach, the establishment of a strong organisational safety culture, immediate psychological first aid, long-term resilience building, the engagement and training of peer supporters, the provision of adequate resources and ongoing support, the importance of leadership commitment and the necessity of tailoring interventions to the specific context and needs of each institution and country considering their diverse sociocultural and legal framework. …”
Get full text

Elucidating the molecular basis of salt tolerance in potatoes through miRNA expression and phenotypic analysis by Caicai Lin, Shuangshuang Zheng, Kui Liu, Ru Yu, Peiyan Guan, Baigeng Hu, Lingling Jiang, Mengyu Su, Guodong Hu, Qingshuai Chen, Xia Zhang

“…Abstract Potatoes are a critical staple crop worldwide, yet their yield is significantly constrained by salt stress. …”
Get full text

Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study by Mai M. Hassanein, Mai M. Hassanein, Yousra A. Hagyousif, Yousra A. Hagyousif, Ruba A. Zenati, Ruba A. Zenati, Hamza M. Al-Hroub, Farman Matloob Khan, Ahmad Y. Abuhelwa, Ahmad Y. Abuhelwa, Karem H. Alzoubi, Karem H. Alzoubi, Nelson C. Soares, Nelson C. Soares, Waseem El-Huneidi, Waseem El-Huneidi, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Eman Abu-Gharbieh, Hany Omar, Hany Omar, Dana M. Zaher, Yasser Bustanji, Yasser Bustanji, Yasser Bustanji, Mohammad H. Semreen, Mohammad H. Semreen

“…It significantly reduced critical metabolites such as guanine, xanthine, inosine, L-fucose, and sphinganine, demonstrating enhanced cytotoxic effects compared to individual treatments. …”
Get full text

Hyperadaptor; Temperature-insensitive tensile properties of Ni-based high-entropy alloy a wide temperature range by Hyojin Park, Sujung Son, Soung Yeoul Ahn, Hyojeong Ha, Rae Eon Kim, Jae Heung Lee, Hyo Moon Joo, Jung Gi Kim, Hyoung Seop Kim

“…Our findings highlight the potential of Ni-based HEA for demanding applications in aerospace, automotive, and energy sectors, establishing them as pioneering materials in alloy development.HIGHLIGHTS Introduces the concept of ‘Hyperadaptor’ materials, which exhibits minimal environmental sensitivity, and demonstrates Ni-based high-entropy alloys (HEAs) as prime examples, showing consistent mechanical properties across a wide temperature range from 77 K to 873 K.Demonstrates minimal temperature sensitivity of Ni-based HEA through analyses of nano-sized L12 precipitates and high stacking fault energy, enhancing strength and ductility.Employs various characterization techniques, including EBSD, ECCI, and TEM, to illustrate the dislocation slip-induced plasticity and precipitation hardening, achieving temperature-independent mechanical performance.Validates the potential of Ni-based HEAs for critical applications in the aerospace, automotive, and energy sectors, emphasizing their consistent mechanical properties under extreme temperature fluctuations.…”
Get full text

How are new collective models transforming support for smallholder farmers? Empirical evidence from thematic and sentiment content analysis by Rajiv B. Kale, Pooja A. Dangi, Vinayak Nikam, Kiran Khandagale, Shailendra S. Gadge, Vijay Mahajan

“…Through this comprehensive analysis, the study seeks to elucidate the emergence of collective models and their potential to address critical agricultural issues faced by smallholder farmers, particularly in India. …”
Get full text

Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings by Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox

“…Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes. …”
Get full text

The Impact of Nurses' Disaster Preparedness Competencies on Public Health Center Resilience in Disaster-Prone Areas: A cross-sectional study by Moh Ikram Dg Sirua, Balqis Balqis, Muhammad Alwy Arifin, Indar Indar, Syamsuar Manyullei

“… Background: Disaster-prone areas need resilient health centers to ensure effective health management services and emergency response during earthquakes and tsunamis. Nurses play a critical role in disaster risk reduction which is essential to improving health center resilience. …”
Get full text

Performing whole-genome association analysis of winter wheat plant height using the 55K chip by Yindeng Ding, Guiqiang Fan, Yonghong Gao, Tianrong Huang, Anding Zhou, Shan Yu, Lianjia Zhao, Xiaolei Shi, Sunlei Ding, Jiahao Hao, Wei Wang, Jikun Song, Na Sun, Hui Fang

“…Plant height is a critical agronomic that affects both plant architecture and yield. …”
Get full text

Biodiversity futures: digital approaches to knowledge and conservation of biological diversity by H. Freitas, H. Freitas, A. C. Gouveia, A. C. Gouveia

“…By providing science and technology stakeholders with recommendations on accelerating the role of digital technologies in biodiversity knowledge and conservation, it aims to catalyse impactful change in this critical field of devising brighter futures for biodiversity and humanity.…”
Get full text

Research on tire tread abrasion performance considering the patten and slippage with verification by Huaqiao Liu, Yao Xiao, Kongshuo Wang, Yukun Zhou, Huiguang Bian, Chuansheng Wang

“…The ABS control slippage during vehicle acceleration and braking provides sufficient grip in contact with the road surface, which is the most critical cause of tire wear. The wear performance of rubber at different slippage is a key factor affecting tire life. …”
Get full text

Bedrock modulates the elevational patterns of soil microbial communities by Xianjin He, Ruiqi Wang, Daniel S. Goll, Laurent Augusto, Naoise Nunan, M.D. Farnon Ellwood, Quanzhou Gao, Junlong Huang, Shenhua Qian, Yonghua Zhang, Zufei Shu, Buhang Li, Chengjin Chu

“…Overall, our results highlight the critical influence of bedrock in determining soil microbial community structure along elevational gradients and their potential responses to climate change.…”
Get full text

Multiphysics analysis of the dual role of magnetoelectric nanoparticles in a microvascular environment: from magnetic targeting to electrical activation by Martina Lenzuni, Paolo Giannoni, Emma Chiaramello, Serena Fiocchi, Giulia Suarato, Paolo Ravazzani, Alessandra Marrella

“…Minimally invasive medical treatments for peripheral nerve stimulation are critically needed to minimize surgical risks, enhance the precision of therapeutic interventions, and reduce patient recovery time. …”
Get full text

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body’s immune response. …”
Get full text

Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions by J. J. Vargas-Duarte, H. Lozano-Márquez, H. A. Grajales-Lombana, C. Manrique-Perdomo, D. A. Martínez-Bello, C. Saegerman, M. Raes, N. Kirschvink

“…Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. …”
Get full text

Integrating behavioral and neurophysiological insights: High trait anxiety enhances observational fear learning by Xianchao Ming, Ganzhong Luo, Jinxia Wang, Haoran Dou, Hong Li, Yi Lei

“…These findings highlight the critical role of trait anxiety as a significant risk factor in the development of anxiety disorders.…”
Get full text

Design and optimization of liquid helium-free cooling systems for magnetic resonance imaging device using multi-physical modeling by Changhao Luo, Guanhua Liu, Yi Deng, Zhiqiang Long, Meng Lin

“…Effective initial cooling is critical in conduction-cooled superconducting magnet systems, especially for medical Magnetic Resonance Imaging (MRI), where traditional reliance on liquid helium poses challenges due to helium resource limitations and high costs. …”
Get full text

High levels of histone acetylation modifications promote the formation of PGCs by Ziduo Zhao, Yuhui Wu, Fufu Cheng, Zhe Wang, Qingqing Geng, Yingjie Niu, Qisheng Zuo, Yani Zhang

“…Functional enrichment analysis indicated these genes are involved in pathways critical for germ cell differentiation, underscoring their importance in avian reproductive biology. …”
Get full text

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023 by Wang Junli, Hao Zhihong, Wang Lina, Ou Qiaoqun, Qu Jing, Hu Jiaqi, Shengyou Yu, Shengyou Yu, Shengyou Yu

“…BackgroundThe glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood. …”
Get full text

Manipulating Intracellular Oxidative Conditions to Enhance Porphyrin Production in <i>Escherichia coli</i> by Bahareh Arab, Murray Moo-Young, Yilan Liu, C. Perry Chou

“…Being essential intermediates for the biosynthesis of heme, chlorophyll, and several other biologically critical compounds, porphyrins have wide practical applications. …”
Get full text

Protecting digital assets using an ontology based cyber situational awareness system by Tariq Ammar Almoabady, Yasser Mohammad Alblawi, Ahmad Emad Albalawi, Majed M. Aborokbah, S. Manimurugan, Ahmed Aljuhani, Hussain Aldawood, P. Karthikeyan

“…IntroductionCyber situational awareness is critical for detecting and mitigating cybersecurity threats in real-time. …”
Get full text