Responses of an <i>In Vitro</i> Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens^®) Following Exposure to Skin Sensitizers and Non-Sensitiz... by Sabina Burla, Aline Chary, Tommaso Serchi, Sébastien Cambier, Kristie Sullivan, Elizabeth Baker, Nikaeta Sadekar, Arno C. Gutleb

“…Respiratory sensitizers are classified as substances of very high concern (SVHC) under the European Union (EU) regulation for the registration, evaluation, authorization and restriction of chemicals (REACH), emphasizing the importance of evaluating respiratory tract sensitization as a critical hazard. However, the existing new approach methodologies (NAMs) for the identification of skin sensitizers lack the capacity to differentiate between skin and respiratory sensitizers. …”
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A new immunofluorescence determination of Parkinson's disease biomarkers using silver nanoparticles by Chao Qin, Jun Xia, Yong Wen, Jun Wang, Chen Zhong

“…In this study, we developed an immunofluorescence detection approach for α-synuclein (α-syn), a critical biomarker associated with PD, that is both extremely sensitive and specific. …”
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Performances of asphalt mastic incorporating with a home-made sustained-releasing salt storage additive by Wei Du, Qing-liang Wang, Yong-xu Li, Xiao-ning Wang, Xiao-cun Liu, Ya-fei Wang, Yan-min Wang, Jin Li

“…The absence of intrinsic deicing capabilities in conventional asphalt mastic poses a critical challenge in cold-climate regions, where the accumulation of snow and ice can result in hazardous traffic conditions. …”
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Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint by Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

“…IL-17 is an inflammatory cytokine produced primarily by Th17 cells which plays critical role in the pathogenesis of numerous autoimmune and inflammatory diseases. …”
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Advanced groundwater potential and contamination vulnerability assessment using integrated GIS-based AHP techniques: A case study from the Bizerte watershed, Tunisia by Cyrine Belhadj, Rihab Riahi, Abdelaziz Sebei, Sinda Sifi, Noamen Rebai

“…Sustainable management and monitoring of groundwater resources are critical for ensuring their availability for drinking, agriculture, and industry worldwide. …”
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Unraveling the interconnectedness between physician burnout and symptoms of depression, anxiety, and stress: a network analysis among Chinese psychiatrists by Song Wang, Song Wang, Mengyue Gu, Mengyue Gu, Shujing Zhang, Jingyang Gu, Jingyang Gu, Yudong Shi, Yudong Shi, Yating Yang, Yating Yang, Ling Zhang, Ling Zhang, Mengdie Li, Mengdie Li, Lei Xia, Lei Xia, Feng Jiang, Feng Jiang, Feng Jiang, Feng Jiang, Huanzhong Liu, Huanzhong Liu, Huanzhong Liu, Yi-lang Tang, Yi-lang Tang

“…Furthermore, depressive symptoms such as hopelessness and anhedonia showed a strong and the most straightforward association with emotional exhaustion, while stress-related overreaction was closely associated with depersonalization.ConclusionNetwork analysis between burnout and psychological symptoms identified critical symptoms like stress and emotional exhaustion in Chinese psychiatrists. …”
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Escape Room Activity to Teach Head and Neck Anatomy by George Holan, Rijul Asri, Abhishek Yadav, Christin Traba, Sophia Chen, Jeremy J. Grachan

“…., interpersonal, problem-solving, critical thinking, adaptability). Students also noted the activity was fun (round A = 86%, round B = 100%). …”
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Differential expression and localization of expansins in Arabidopsis shoots: implications for cell wall dynamics and drought tolerance by Darina Balkova, Katerina Mala, Jan Hejatko, Jan Hejatko, Klara Panzarova, Lamis Abdelhakim, Barbora Pleskacova, Marketa Samalova, Marketa Samalova

“…These findings highlight the critical role of EXPA1 in regulating plant growth, development, and stress response, with potential applications in improving drought tolerance in crops.…”
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Optimal configuration strategy of energy storage considering flexible response of high energy-consuming industrial and mining loads in independent microgrid by Cuomu Yixi, Xiaoming Liu, Yu Li, Jingming Tan, Zhihong Liu, Basang Danzeng, Lei Wang

“…The coordinated optimization of industrial and mining loads with energy storage (ES) is a critical approach to achieving power and energy balance in microgrids while promoting the new energy accommodation. …”
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Impacts of Land Use on Soil Erosion: RUSLE Analysis in a Sub-Basin of the Peruvian Amazon (2016–2022) by Moises Ascencio-Sanchez, Cesar Padilla-Castro, Christian Riveros-Lizana, Rosa María Hermoza-Espezúa, Dayan Atalluz-Ganoza, Richard Solórzano-Acosta

“…In conclusion, the transition from forest to farmland was related to the most critical erosion values. Unsustainable soil management practices can be the underlying explanation of changes in soil chemical and physical properties. …”
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HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Abstract Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, thus representing promising targets for immunotherapy. …”
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The Analytical Approach to Evaluate the Load-Displacement Relationship of Rock Bolts by Jianhang Chen, Shengli Yang, Hongbao Zhao, Junwen Zhang, Fulian He, Shuaifeng Yin

“…However, once Young’s modulus of the confining medium was beyond a critical limit, it had marginal effect on the peak load of rock bolts. …”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…These findings suggest that different metabolic pathways play a critical role at different stages of cellular development, each contributing to diverse cellular functions.DiscussionOur study demonstrates the efficacy of the MetaboLINK approach in analyzing NMR-based longitudinal metabolomic datasets, highlighting key metabolic shifts during cellular transitions. …”
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Numerical modeling of the long-term poromechanical performance of a deep enhanced geothermal system in northern Québec by Saeed Vadiee, Biao Li, Jasmin Raymond, Mafalda M. Miranda

“…The analysis indicates no potential for fault reactivation, as slip tendency values remain below the critical threshold, even when accounting for reduced mechanical properties using the Hoek-Brown criterion. …”
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Multiobjective Optimization-Based Hyperspectral Unsupervised Band Selection for Anomaly Detection by Shihui Liu, Bing Xue, Meiping Song, Haimo Bao, Mengjie Zhang

“…Band selection (BS) is a critical topic in hyperspectral image dimensionality reduction, focusing on identifying representative bands that can convey the essential information of the full bands without significant loss. …”
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PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis by Ganggang Li, Yuwei Zhang, Huanyu Jiang, Xuanyu Wu, Yanwei Hao, Yuchen Su, Yutong Zou, Wenjia Xian, Fei Wang, Quanyu Du

“…In conclusion, these findings highlight the critical role of lipid metabolism in IPF and present novel molecular targets for the development of future therapeutic strategies.…”
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Knowledge and awareness of asbestos risk among General Practitioners: Validation of a questionnaire in an area with a high incidence of asbestos-related diseases by Marinella Bertolotti, Manuela Tamburro, Angelo Salzo, Antonella Cassinari, Stefania Crivellari, Carlotta Bertolina, Marianna Farotto, Carmen Adesso, Michela Anna Di Palma, Anna Natale, Federico Torregiani, Guglielmo Pacileo, Antonio Maconi, Giancarlo Ripabelli

“…Objective: Given the critical role of general practitioners (GPs) in the early diagnosis and management of asbestos-related diseases (ARDs), and the significant history of asbestos fibres pollution in Alessandria Local Health Authority (ASL AL), this project aimed to assess the knowledge and awareness of asbestos risks, as well as the experience in diagnosing ARDs among GPs working in Alessandria province, Northern Italy. …”
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A Comprehensive 10-Year Nationwide Pharmacovigilance Surveillance on Antibacterial Agents in Korea: Data Mining for Signal Detection of Trends and Seriousness of Adverse Events by Seon Hu Mo, Soo Hyeon Lee, Chang-Young Choi, Yongjun Sunwoo, Sooyoung Shin, Yeo Jin Choi

“…However, further studies are imperative to determine the causality of antibacterial-induced ADEs in critically ill patients.…”
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Mechanisms and Production Enhancement Effects of CO₂/CH₄ Mixed Gas Injection in Shale Oil by Xiangyu Zhang, Qicheng Liu, Jieyun Tang, Xiangdong Cui, Shutian Zhang, Hong Zhang, Yinlong Lu, Xiaodong Dong, Hongxing Yan, Mingze Fu, Yuliang Su, Zheng Chen

“…Shale oil, a critical unconventional energy resource, has received substantial attention in recent years. …”
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Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India by Nabeela Usmani, Mukhtar Ahmad, Saba Khan, Mohammad Mustufa Khan, Haseeb Ahsan, Sadaf Parveen, Roshan Alam

“…Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. …”
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