Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways by Shijia Tang, Yue Yan, Xiaoli Lu, Peng Wang, Xueqin Xu, Ke Hu, Sen Yan, Zhaobin Guo, Xiao Han, Feimin Zhang, Ning Gu

“…Abstract Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical factors to promote the osteogenic differentiation of stem cells has been established as a new strategy for developing bone tissue engineering scaffolds. …”
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Genotyping Genebank Collections: Strategic Approaches and Considerations for Optimal Collection Management by Noelle L. Anglin, Peter Wenzl, Vania Azevedo, Charlotte Lusty, David Ellis, Dongying Gao

“…The maintenance of plant germplasm and its genetic diversity is critical to preserving and making it available for food security, so this invaluable diversity is not permanently lost due to population growth and development, climate change, or changing needs from the growers and/or the marketplace. …”
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Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses by Chukwudi A. Ofodile, Ikemefuna C. Uzochukwu, Fortunatus C. Ezebuo, InnocentMary Ejiofor, Mercy Adebola, Innocent Okpoli, Beatrice Cubitt, Haydar Witwit, Chetachi B. Okwuanaso, Ngozi Onyemelukwe, Juan Carlos de la Torre

“…We used in silico docking approaches to investigate the binding affinities of 2015 existing drugs to LASV proteins known to play critical roles in the formation and activity of the virus ribonucleoprotein complex (vRNP) responsible for directing replication and transcription of the viral genome. …”
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An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy by Fumio Takano, Kaori Ueda, Takuji Kurimoto, Mina Arai, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

“…The secondary outcomes included changes in visual field; LogMAR; critical flicker frequency; and inner retinal thickness. …”
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The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…Survival analysis was conducted to screen and validate critical genes. In this study, 775 downregulated DEGs were identified. …”
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Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…Methodologists and researchers have criticized current scale development practices, emphasizing that inaccurate measurements can derail theory development and clinical decisions, thereby impeding progress in mental health research and practice. …”
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Assessment of ozone impact on forest vegetation using visible foliar injury, AOT40F exposure index and MDA concentration in two meteorologically contrasting years by Radek Novotný, Leona Vlasáková, Vít Šrámek, Václav Buriánek, Nina Benešová

“…AOT40F values exceeded the critical level of 5 ppm.h-1 at all plots, with higher values in 2022. …”
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Perspectives of healthcare stakeholders in Nigeria on the impact of COVID-19 on health services by Adeponle O. Adeoye, Yewande T. Nejo, Chinwe L. Ochu, Josephine Bayigga, Rodgers R. Ayebare, Adedayo O. Faneye, Charles O. Adewemimo, Oluwaseun Emmanuel Falayi, Adeniyi Francis Fagbamigbe, Prosper Okonkwo, Adewale Victor Opayele, Gloria Ogochukwu Nwiyi, Sunday Obiajunwa Eziechina, Ikemefule Rex Uzoma, Priscilla Ibekwe, Tamrat Shaweno, Nebiyu Dereje, Francis Kakooza, Mosoka Papa Fallah, Georgina Njideka Odaibo

“…Background: COVID-19 disrupted critical public health services globally. It is important to understand how the pandemic affected healthcare service delivery and utilisation in Nigeria to guide planning for future public health crises in the country. …”
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Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice by Ana Paula M. S. Brandão, Fernanda S. Oliveira, Natalia B. Carvalho, Leda Q. Vieira, Vasco Azevedo, Gilson C. Macedo, Sergio C. Oliveira

“…Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockout mice were used to determine whether CD8+ T cells and IL-12-dependent IFN-γ deficiency would be more critical to control B. abortus infection compared to the lack of endogenous IFN-γ. …”
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Irritable Bowel Syndrome: Gut Microbiota Dysbiosis and Psychological Co-morbidities by Bijita Bhowmick, Sharmistha Banerjee, Sanchaita Gayen, Supriya Samanta, Nilotpal Banerjee

“…Emerging evidence highlights a critical imbalance in gut microbiota among individuals with IBS, underscoring the intricate gut-brain-microbiome axis. …”
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Piezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca2+-dependent calpain/HIF-1α/Notch signaling by Xiaoting Chen, Jintao Jiang, Bin He, Shangfei Luo, Qiaorui Tan, Youfen Yao, Rentao Wan, Honglin Xu, Silin Liu, Xianmei Pan, Xin Chen, Jing Li

“…Piezo1 activates Ca2+-dependent calpain signaling, which critically upregulates HIF-1α signaling. This key pathway subsequently influences the Notch and CCL2/CCR2 pathways, driving the polarization of M1 macrophages. …”
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Elevation-dependent shift of landslide activity in mountain permafrost regions of the Qilian Mountains by Jie Chen, Jing Zhang, Tong-Hua Wu, Lin Liu, Fan-Yu Zhang, Jun-Ming Hao, Ling-Cao Huang, Xiao-Dong Wu, Peng-Ling Wang, Zhuo-Xuan Xia, Xiao-Fan Zhu, Pei-Qing Lou

“…These findings highlight the critical role of elevation-dependent processes in influencing landslide dynamics under changing climatic conditions, particularly the transition from undisturbed permafrost to seasonally frozen ground at higher elevations. …”
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Investigating the effects of alkalization on mechanical properties of enset fibers using digital image correlation technique by Abebayehu Abdela, Bart Buffel, Belete Sirahbizu, Frederik Desplentere

“…The vital role in treated fibers is attributed to the concentration of sodium hydroxide, with the duration of immersion also being a critical factor. Therefore, lignocellulosic structure of Enset fiber must be considered when evaluating its tensile strength. …”
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Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

“…This innovative strategy can potentially enhance vascularization in large tissue-engineered constructs, addressing a critical limitation in current bone regeneration techniques. …”
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Chinese nurses’ perspectives on child-friendly healthcare practice assessment: a qualitative study by Wei Xiao Huang, Mei Chan Chong, Li Yoong Tang, Xiao Xia Liu, Mei Fang, Yun Yun Shen, Xiao Li Guo

“…Abstract Background Nurses play a critical role in the implementation of child-friendly healthcare, ensuring that pediatric patients receive comprehensive and compassionate services. …”
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Impact of Frequency Heterogeneity on Mutually Synchronized Spatially Distributed 24 GHz PLLs by Christian Hoyer, Jens Wagner, Frank Ellinger

“…The study underscores the critical importance of operating ranges when implementing mutual coupling. …”
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Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents by Valeria Calcaterra, Valeria Calcaterra, Francesca Penagini, Virginia Rossi, Luisa Abbattista, Alice Bianchi, Massimiliano Turzi, Lucia Cococcioni, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…Since the thyroid plays a critical role in the pediatric population’s development, it is essential to promptly recognize and treat thyroid diseases. …”
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Concordance between Immunohistochemistry and Microarray Gene Expression Profiling for Estrogen Receptor, Progesterone Receptor, and HER2 Receptor Statuses in Breast Cancer Patients... by Ghina B. Fakhri, Reem S. Akel, Maya K. Khalil, Deborah A. Mukherji, Fouad I. Boulos, Arafat H. Tfayli

“…Accurate evaluation of estrogen and progesterone receptors and HER2 is critical when diagnosing invasive breast cancer for optimal treatment. …”
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IoT-Based Multisensors Fusion for Activity Recognition via Key Features and Hybrid Transfer Learning by Ahmad Jalal, Danyal Khan, Touseef Sadiq, Moneerah Alotaibi, Sultan Refa Alotaibi, Hanan Aljuaid, Hameedur Rahman

“…Accurate HAR can enhance user experience, provide critical health insights, and enable sophisticated context-aware applications. …”
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Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 by Shifu Bao, Shifu Bao, Weibu Jimu, Weibu Jimu, Nai Mu, Fang Yan, Shuxing Xing, Tao Li, Zheng Zhou

“…The association varied notably across demographic and health-related subgroups, being particularly significant in females, individuals with obesity, and those with lower physical activity.ConclusionThese findings highlight the critical importance of muscle mass in slowing biological aging, with systemic inflammation emerging as a key biological mediator. …”
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