Theoretical finishing size limitation and failure mechanism of viscoelastic abrasive media on micro-hole structure by Baocai Zhang, Xiayu Wang, Neng Jiang, Jun Tang, Fanghong Sun, Xinchang Wang

“…However, as the primary requirement of media is the material removal, there must be a limitation size when the micro hole reducing to a critical value since the rigid grains should be added and must hold an apparent dimension. …”
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Understanding empathy and theory of mind in Romanian dental students for improved educational strategies by Ancuta Mioara Banu, Sorin Ursoniu, Smaranda Laura Gotia, Salomeia Putnoky, Costela Lacrimioara Serban

“…Abstract Empathy and theory of mind (ToM) are critical components of social cognition that significantly impact patient care. …”
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Using artificial intelligence based language interpretation in non-urgent paediatric emergency consultations: a clinical performance test and legal evaluation by Julia Brandenberger, Ian Stedman, Noah Stancati, Karen Sappleton, Sarathy Kanathasan, Jabeen Fayyaz, Devin Singh

“…Conclusions Google Translate can effectively support communication in specific non-critical paediatric emergency scenarios. However, its use necessitates careful monitoring, understanding of its limitations, and attention to dialect and literal translation risks along with equity considerations. …”
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Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease by Abhishek A. Revankar, Archana S. Patil, Reshma Karishetti, Krutuja R. Chougule, Priyanka Patil, Abhijit Salokhe

“…This study investigates the formulation of quercetin, a natural bioflavonoid with potent antioxidant and anti-inflammatory properties, as niosomes for intranasal delivery to enhance its bioavailability and therapeutic potential for PD.MethodsThe niosomal formulation was optimized for critical parameters including particle size, entrapment efficiency, and zeta potential. …”
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Comparison of management options for spontaneous bleeding into soft tissues in patients with COVID-19 by A. E. Tyagunov, D. Y. Trudkov, A. Y. Polyaev, E. A. Stradymov, M. V. Baglaenko, S. V. Mosin, A. V. Sazhin

“…Abstract Spontaneous bleeding into soft tissues was a common complication of anticoagulant therapy among critically ill patients during the COVID-19 pandemic. …”
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The Deadly Details: How Clear and Complete Are Publicly Available Sources of Human Rabies Information? by Natalie Patane, Owen Eades, Jennifer Morris, Olivia Mac, Kirsten McCaffery, Sarah L. McGuinness

“…Visual aids were under-utilised, and critical vaccine-specific information was often lacking. …”
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A Weighted Bayesian Kernel Machine Regression Approach for Predicting the Growth of Indoor-Cultured Abalone by Seung-Won Seo, Gyumin Choi, Ho-Jin Jung, Mi-Jin Choi, Young-Dae Oh, Hyun-Seok Jang, Han-Kyu Lim, Seongil Jo

“…Our analysis reveals that time, dissolved oxygen, salinity, and nutrient supply are the most critical factors influencing growth, while water temperature and pH play relatively minor roles under controlled indoor farming conditions. …”
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Bioinformatics analysis of miRNAs germacrone protection on diabetic nephropathy by Binqi Wang, Wenfang He, Zhixuan Xie, Jinshi Zhang, Yan Ren, Qiang He, Juan Jin

“…This study used comprehensive bioinformatics analysis to identify critical microRNAs (miRNAs) and the potential underlying pathways related to germacrone activities. …”
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Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration by Jouda Gamara, Lynn Davis, Emmanuelle Rollet-Labelle, Tsunaki Hongu, Yuji Funakoshi, Yasunori Kanaho, Fawzi Aoudjit, Sylvain G. Bourgoin

“…Chemoattractant sensing, adhesiveness, and migration are critical events underlying the recruitment of neutrophils (PMNs) to sites of inflammation or infection. …”
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DNA origami-designed 3D phononic crystals by Park Sung Hun, Park Haedong, Nam Jwa-Min, Ke Yonggang, Liedl Tim, Tian Ye, Lee Seungwoo

“…Moulding the flow of phononic waves in three-dimensional (3D) space plays a critical role in controlling the sound and thermal properties of matter. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…This review first outlines the key regulatory enzyme mediating ac4C modification, N‐acetyltransferase 10 (NAT10), including its critical roles in regulating RNA stability, transcriptional efficiency, and translational fidelity. …”
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Synergistic Effects of FGF-18 and TGF-β3 on the Chondrogenesis of Human Adipose-Derived Mesenchymal Stem Cells in the Pellet Culture by Liangjie Huang, Lingxian Yi, Chunli Zhang, Ying He, Liangliang Zhou, Yan Liu, Long Qian, Shuxun Hou, Tujun Weng

“…Our results provide critical information on the therapeutic use of ADSCs with the help of FGF-18 and TGF-β3 for cartilage regeneration.…”
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Kinetic investigation of the energy storage process in graphene fiber supercapacitors: Unraveling mechanisms, fabrications, property manipulation, and wearable applications by Juan Zhang, Wenwen Liu, Minzhi Du, Qingli Xu, Minren Hung, Ruifang Xiang, Meng Liao, Xinhou Wang, Bingjie Wang, Aiping Yu, Kun Zhang

“…Building on the established structure–property relationship, several critical strategies for constructing optimal surface and structure profiles of GF electrodes are summarized. …”
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Classification of disinformation in hybrid warfare: an application of XLNet during the Russia’s war against Ukraine by Halyna Padalko, Vasyl Chomko, Sergiy Yakovlev, Plinio Pelegrini Morita

“…The spread of disinformation has become a critical component of hybrid warfare, particularly in Russia’s war against Ukraine, where social media serves as a battlefield for influence and propaganda. …”
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The polarity of high-definition transcranial direct current stimulation affects the planning and execution of movement sequences by Jake J. Son, Tara D. Erker, Thomas W. Ward, Yasra Arif, Peihan J. Huang, Jason A. John, Kellen M. McDonald, Nathan M. Petro, Grant M. Garrison, Hannah J. Okelberry, Kennedy A. Kress, Giorgia Picci, Elizabeth Heinrichs-Graham, Tony W. Wilson

“…Determining the impact of such neurostimulation on the neural processing supporting motor control is a critical step toward further harnessing its therapeutic potential in multiple neurological conditions affecting the motor system. …”
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Role of white-tailed deer in geographic spread of the black-legged tick Ixodes scapularis : Analysis of a spatially nonlocal model by Stephen A. Gourley, Xiulan Lai, Junping Shi, Wendi Wang, Yanyu Xiao, Xingfu Zou

“…We derive an algebraic equation that determines a critical value $c^*$ which is at least a lower bound for the wave speed in the sense that, if $c < c^*$, there is no traveling wave front of speed $c$ connecting the extinction steady state to the positive steady state. …”
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USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…Furthermore, USP4-mediated CENPF upregulation was critical regulators of metastasis of CRC. Examination of clinical samples confirmed that USP4 expression positively correlates with CENPF protein expression, but not mRNA transcript levels. …”
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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…Abstract The study aimed to elucidate the underlying pharmacological mechanism of the traditional Chinese medicine Pue in ameliorating myocardial ischemia-reperfusion injury (MIRI), a critical clinical challenge exacerbated by reperfusion therapy. …”
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Computational epitope-based vaccine design with bioinformatics approach; a review by Esmaeil Roohparvar Basmenj, Susan Radman Pajhouh, Afsane Ebrahimi Fallah, Rafe naijian, Elmira Rahimi, Hossein Atighy, Shadan Ghiabi, Shamim Ghiabi

“…The significance of vaccine development has gained heightened importance in light of the COVID-19 pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. …”
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Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease by Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou

“…In silico studies on the complexes of the oligomeric state of A<i>β</i> and Cathepsin B peptide analogs were performed utilizing molecular docking and molecular dynamics simulations, revealing that these analogs disrupt the <i>β</i>-sheet-rich core of A<i>β</i> oligomers, a critical structural feature of their stability. Of the four peptide analogs evaluated, two demonstrated considerable potential by effectively destabilizing oligomers while maintaining low self-aggregation propensity, i.e., a crucial consideration for therapeutic safety. …”
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