Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies by Hassan Sepehrmansourie, Mohammad Azimi, Ahmad Ebadi, Gholamabbas Chehardoli, Mohammad Ali Zolfigol, Massoud Amanlou, Mohammad Nazari Montazer, Mohammad Mahdavi, Zahra Najafi

“…The stable enzyme-inhibitor complex in molecular dynamics simulations (MD) indicated critical interactions between the ligand and the Cys592 and His593 residues, which stabilize the flap motif of the enzyme. …”
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Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study by Sanjay M Mehendale, Kamini Walia, Pallab Ray, Nusrat Shafiq, Shankar Prinja, Sagar Khadanga, Susmita Chatterjee, Raman Gangakhedkar, Samiran Panda, Sanjay Bhattacharya, Megha Mamulwar, Abhijit Kadam, Gayatri Bhambure, Shilpa Bembalkar, Shraddha Bapat, Arati Mane, Shobha Rajure, Jayanthi Mathaiyan, Yamunadevi Ramanathan, Vijayshri Suresh Deotale, Gourangie Gogoi, Ruchita Attal, Jharna Mandal, Venkateswaran Ramanathan

“…In the prospective component, 46.5% of patients resorted to borrowing money for hospitalisation expenses and the per day median total cost for resistant and sensitive infection was estimated to be US$65 and US$35, respectively.Conclusions The current study concluded that the presence of any critical or high priority pathogens led to an increase in the direct and indirect medical costs. …”
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A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma by Dantong Sun, Helei Hou, Feiyue Feng, Weizheng Wu, Jingyu Tan, Tongji Xie, Jiayu Liu, Jinsong Wang, Haili Qian, Junling Li, Puyuan Xing

“…Abstract Background Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. …”
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Multi-disciplinary treatment of broncho-esophageal fistula in a high-risk single-lung patient by Rune Haaverstad, Kjell Ovrebo, Lorentz Sandvik, Håvard Seland, Gunnar Reksten Husebø, Vegard Skalstad Ellensen, Marit Farstad, Eivind Strandenes, Rajinder Sharma, Marianne Øksnes, Anders Kjellevold Storesund, Solveig Moss Kolseth

“…It was complicated by thrombotic occlusion of the upper venous system, repeated postoperative bleedings and critical illness neuropathy. The patient recovered and was discharged 150 days after surgery. …”
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Normalization of Cystic Fibrosis Immune System Reverses Intestinal Neutrophilic Inflammation and Significantly Improves the Survival of Cystic Fibrosis MiceSummary by Callie E. Scull, Yawen Hu, Scott Jennings, Guoshun Wang

“…Conclusions: CF immune defect plays a critical role in CF intestinal disease development. …”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Radiation oncologists and immunologists convened a virtual consensus discussion to identify current deficiencies, challenges, pitfalls and critical gaps when combining radiotherapy with immunotherapy and making recommendations to the field and advise National Cancer Institute on new directions and initiatives that will help further development of these two fields.This commentary aims to raise the awareness of this complexity so that the need to study radiation dose, fractionation, type and volume is understood and valued by the immuno-oncology research community. …”
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Best practice mechanisms for biodiversity conservation law and policy by Callum Brockett, Katie Woolaston, Felicity Deane, Fran Humphries, Ethan Kumar, Amanda Kennedy, Justine Bell-James

“…Laws for the conservation of biodiversity form a critical component for minimising the drivers of extinction, with species extinction being an extreme outcome of biodiversity loss. …”
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Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

“…Abstract Background Although the TNM staging system plays a critical role in guiding adjuvant chemotherapy for colorectal cancer (CRC), its precision for risk stratification in stage II and III CRC patients with proficient DNA mismatch repair (pMMR) remains limited. …”
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Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3 by Wan-Xiang Xu, Ya-Ping He, Jian Wang, Hai-Ping Tang, Hui-Juan Shi, Xiao-Xi Sun, Chao-Neng Ji, Shao-Hua Gu, Yi Xie

“…The human zona pellucida glycoprotein-3 (hZP3) by virtue of its critical role during fertilization has been proposed as a promising candidate antigen to develop a contraceptive vaccine. …”
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Effectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol by Irene Brandt, Sylvain Some, Ourohiré Millogo, Oumar Sourabié, Jacob Burns, Sachin Shinde, Matthias Haucke, Nathan Sivewright, Christine Neumann, Shraddha Bajaria, Katian Napon, Clarisse Dah, Marina Taonda, Jason T. Siegel, Mary Mwanyika Sando, Till Bärnighausen, Ali Sié, Shuyan Liu

“…This underscores the critical need to enhance mental health literacy among adolescents and youth, empowering them to manage their mental well-being effectively. …”
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Evaluating the Accessibility of Urban Public Open Spaces Based on an Improved 2SFCA Model: A Case Study Within Chengdu’s Second Ring Road by Ling Jian, Xiaojiang Xia, Yinbing Zhao, Yang Zhang, Yuanqiao Wang, Yi Tang, Jie Chang, Changliu Wang

“…The rational allocation of urban public open spaces (UPOS) is critical for creating a livable urban environment. …”
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Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extra... by Yun Zuo, Jie Wang, Xiaoju Huang, Yuan Liu, Zhiwu Zeng, Ruiqing Xu, Yawen Chen, Kui Liu, Hongkang You, Jingang Wang

“…They are important devices; however, in the harsh environment of the soil, they are prone to corrosion or even fracture, which in turn affects the normal utilization of the transmission line, so accurately assessing the condition of grounding bodies of the power grid is critical. To assess the operational status of a grounding body in a timely manner, this paper proposes a multi-parameter pulsed eddy current (PEC) time-domain characteristic signal corrosion classification method for the detection of the state of a pole tower grounding body. …”
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Evaluation of Cold Chain Management Performance for Temperature-Sensitive Pharmaceuticals at Public Health Facilities Supplied by the Jimma Pharmaceuticals Supply Agency Hub, South... by Diriba Feyisa, Awol Jemal, Temesgen Aferu, Fikadu Ejeta, Alem Endeshaw

“…Supply chain performance at the study facilities was not adequate overall, and focused efforts need to be directed at managing the availability of critical cold chain medicines. Some cold chain management challenges demand the attention of the top management, while the rest can be addressed by operational management at the facilities through provision of appropriate training and supervision of the cold chain pharmaceutical handlers.…”
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The impact of export market orientation on SME market performance: Exploring the moderating effect of government policy and the mediating effect of information access by Sunday Noya, Stefanus Yufra M. Taneo, Melany

“…The findings demonstrate that export market orientation significantly boosts SME market performance (path coefficient = 0.512, p < 0.001), highlighting its critical role in fostering customer-oriented practices and adaptive marketing strategies. …”
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SEC61 translocon gamma subunit is correlated with glycolytic activity, epithelial mesenchymal transition and the immune suppressive phenotyp... by Zhou Changshuai, Cui Huanhuan, Yang Yuechao, Chen Lei, Feng Mingtao, Gao Yang, Li Deheng, Li Liangdong, Chen Xin, Li Xiaoqiu, Cao Yiqun

“…Remarkably, we identify a negative association between SEC61G expression levels and the infiltration of critical immune cell populations within the TME, along with correlations with immune checkpoint gene expression and tumor heterogeneity scores in LUAD. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…These findings suggest that zinc-regulated MT1B plays a critical role in lipid metabolism and inflammatory responses by regulating the AKT/PI3K signaling pathway, influencing MASH progression.…”
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HIV status and contraceptive use in Zimbabwe among sexually active adolescent girls and women: Secondary analysis of Zimbabwe Demographic Health survey data by G Musuka, G Murewanhema, Z Mukandavire, I Chingombe, D Cuadros, F Mutenherwa, T Dzinamarira, R Eghtessadi, N Malunguza, M Mapingure

“…Understanding the pattern of contraceptive use among women living with HIV is critical for formulating relevant public health interventions to improve the uptake and use of reliable methods in this population. …”
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Effect of improving food security on parenting practices and caregiver–adolescent relationships: qualitative findings of an income-generating agricultural intervention in rural Ken... by Maricianah A. Onono, Lila Sheira, Edward A. Frongilio, Gladys Odhiambo, Pauline Wekesa, Amy Conroy, Elizabeth A. Bukusi, Craig R. Cohen, Sheri D. Weiser

“…Further research is needed to explore how to harness the social benefits of agricultural interventions to best address the critical intersections among food insecurity, parenting practices and adolescent mental health. …”
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Comparative growth kinetics and drug susceptibility of Mycobacterium tuberculosis lineages prevalent in Ethiopia: implications for tuberculosis treatment and management by Tesfaye Gebreyohannis Hailemariam, Tesfaye Gebreyohannis Hailemariam, Melaku Tilahun, Abay Atnafu, Tesfaye Gelanew, Tewodros Tariku Gebresilase, Mekdes Alemu Tola, Abaysew Ayele, Shewki Moga Siraj, Workineh Shibeshi, Kidist Bobosha, Liya Wassie, Yonas Hirutu, Ephrem Engidawork

“…Sub-lineages 4.1.2.1 and 4.2.2.2 had MIC values matching WHO’s critical concentrations (except for rifampicin). Lineage 3 showed increased sensitivity to rifampicin, isoniazid, and streptomycin, requiring only half the standard concentration. …”
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S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

“…Here, we identify sphingosine-1-phosphate receptor 3 (S1PR3) as a critical regulator of STAT3 activation and psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustains keratinocyte hyperproliferation and chronic inflammation. …”
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