Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…However, this regenerative capacity can be compromised by various factors, most importantly related with the extent of the injury. Critical-sized defects, exceeding the body’s natural healing ability, demand the use of temporary or permanent devices like artificial joints or bone substitutes. …”
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How does the medicines retail sector ensure continued access to medicines during public health emergencies? Lessons from the COVID-19 pandemic in Uganda by Eleanor Hutchinson, Sunday Mundua, Jessica Myers, Sian E. Clarke, Kristian Schultz Hansen, Chrispus Mayora, Freddie Ssengooba, Freddy Eric Kitutu

“…They adapted, finding new ways to purchase medicines but overall sales of medicines fell.Conclusions The MRS is critical to the distribution of medicines in many countries. …”
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Verbal fluency and semantic association deficits in children with in birth nonprogressive neuromuscular diseases by Maria Koriakina, Maria Koriakina, Olga E. Agranovich, Ioannis Ntoumanis, Maxim Ulanov, Isak B. Blank, Anna Shestakova, Evgeny Blagovechtchenski

“…This relevance is particularly noted in children with severe motor disorders (MD) from birth, highlighting a need to explore how these disorders may impede cognitive functions.MethodsIn this study, we assessed verbal fluency, a critical component of speech function, in 68 children aged 7 to 15. …”
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NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity by Rui Ma, Zhenlong Li, Hejun Tang, Xiaojin Wu, Lei Tian, Zahir Shah, Ningyuan Liu, Tasha Barr, Jianying Zhang, Sean Wang, Srividya Swaminathan, Guido Marcucci, Yong Peng, Michael A. Caligiuri, Jianhua Yu

“…Abstract NKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Bcl-2 (B-cell lymphoma 2), encoded by the human Bcl-2 gene, is a critical anti-apoptotic protein that regulates cell death pathways, primarily by inhibiting apoptosis. …”
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The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression by Yige Zhao, Yong Li, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang

“…Tumor cells promote CAF generation, and the CAFs, in turn, improve the invasiveness and metastasis of the malignant T cells through the IL-6/JAK2/STAT3/SOX4 or IL-6/HIF-1α/SOX4 pathway. SOX4 may be a critical regulatory gene of this positive feedback loop. …”
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Osteoclastogenesis markers in craniofacial bone defects after demineralized dentin material membrane implantation as guided bone regeneration by Dedy Agoes Mahendra, Anita Yuliati, Masfueh Razali, Noor Hayaty Abu Kasim, Muhammad Alwino Bayu Firdauzy, Retno Indrawati Roestamadji, Pratiwi Soesilawati

“…The osteoclast cells count generally showed a critical period with the highest increase in the K(−) group on day 14 of 73.00±0.00. …”
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SARS-CoV-2 Ct values and COVID-19 symptoms in patients with haematological malignancies in South Africa by Keitumetsi L. Sothoane, Sarah A. Van Blydenstein, Vinitha Philip, Jeannette Wadula

“…This information can be critical for chemotherapy timing to minimize adverse outcomes. …”
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ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling by Man Sup Kwak, Myeonggil Han, Yong Joon Lee, Seoyeon Choi, Jeonghwa Kim, In Ho Park, Jeon-Soo Shin

“…Intermolecular disulfide bond formation is critical for protein oligomerization that regulates biological functions. …”
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High Frequency Vibration Fatigue Behavior of Ti6Al4V Fabricated by Wire-Fed Electron Beam Additive Manufacturing Technology by P. Wanjara, J. Gholipour, E. Watanabe, K. Watanabe, T. Sugino, P. Patnaik, F. Sikan, M. Brochu

“…In this study, the vibratory fatigue behavior of Ti6Al4V deposited using wire-fed electron beam additive manufacturing (EBAM) was examined with the motivation of developing an advanced repair solution for fatigue critical cold-section parts, such as blades and vanes, in gas turbine engine applications. …”
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Facilitators and barriers to parental involvement in neonatal pain management in the NICU: a scoping review by Min Shi, Jie Jing, Binzhi Tang, Lu Feng, Linli Xie

“…Of the 10 facilitator themes, the most critical theme was informational and emotional support. …”
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Analysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life by L Bernal-Masferrer, T Gracia-Cazaña, L Najera-Botello, MC Gomez-Mateo, P Cerro, MC Matei, M Gallego-Rentero, S González, A Juarranz, Y Gilaberte

“…Results: Tumor thickness was found to be a critical determinant of MAL-PDT response, with thicker nodular BCCs showing reduced response rates compared to thinner, superficial BCCs and BD lesions. …”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. The Steered MD simulations demonstrated the high affinity of the compounds for PKM2, as evidenced by the requirement of high rupture forces to induce an unbinding event. …”
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A strategy to increase identification of patients with Familial Hypercholesterolemia: Application of the Simon Broome lipid criteria in a large-scale retrospective analysis by James K. Fleming, Renee M. Sullivan, David Alfego, Natalia T. Leach, Tamara J. Richman, Jill Rafalko

“…Conclusion: A laboratory-developed algorithm using Simon Broome lipid criteria can help identify patients who may benefit from additional FH evaluation. While critical, testing hyperlipidemic children for FH is grossly underutilized, as is genetic testing for FH. …”
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Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects by Bruno C. Menarim, DVM, PhD, Chan Hee Mok, PhD, Kirsten E. Scoggin, PhD, Alexis Gornik, DVM, Emma N. Adam, DVM, PhD, Shavahn C. Loux, PhD, James N. MacLeod, VMD, PhD

“…Untreated lesions unexpectedly failed to represent critical-sized defects and at 2 weeks exhibited new subchondral bone covered by a fibrocartilage layer that thinned over time. …”
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Lopinavir and Ritonavir have High Affinity Toward the SARS-CoV-2 S-protein Receptor-binding Domain Sequenced in Brazil by Aline Diogo Marinho, Helyson Lucas Bezerra Braz, João Alison de Moraes Silveira, Danilo Galvão Rocha, Roberta Jeane Bezerra Jorge, Geanne Matos de Andrade

“…Understanding the structural and functional interactions between the virus and host cells is critical for developing therapeutic strategies. Methods: In this study, we employed in silico docking models to investigate the molecular interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike glycoprotein, derived from the Brazilian genome sequence, and seven clinically approved drugs: umifenovir, darunavir, lopinavir, ritonavir, remdesivir, pirfenidone, and oseltamivir. …”
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Awareness and Attitude Toward Artificial Intelligence Among Medical Students and Pathology Trainees: Survey Study by Anwar Rjoop, Mohammad Al-Qudah, Raja Alkhasawneh, Nesreen Bataineh, Maram Abdaljaleel, Moayad A Rjoub, Mustafa Alkhateeb, Mohammad Abdelraheem, Salem Al-Omari, Omar Bani-Mari, Anas Alkabalan, Saoud Altulaih, Iyad Rjoub, Rula Alshimi

“…The perspective and understanding of medical students are critical for guiding the development of educational curricula and training. …”
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Dengue fever in Yemen: a five-year review, 2020–2024 by Wadhah Hassan Edrees, Wadee Abdullah Al-Shehari, Ahmed Mohammed Al-Haddad, Lutf Mohammed Alrahabi, Osama Saleh Al-Haddad, Ali Ahmed Al-Halani

“…Conclusion These findings indicate that the rates of DF cases have increased in Yemen over the last few years. Therefore, it is critical to introduce an effective program to prevent DF and control dengue vector transmission in Yemen.…”
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Effects of abscisic acid and gibberellin on sugar accumulation in 'Fengtang' Plum (Prunus salicina LindI.) by Qianjun Song, Xiaoshuang Nie, Hong Chen

“…The expression of fruit sugar fractions and related genes was determined by spraying different concentrations of exogenous  abscisic acid (ABA) and Gibberellic acid 3 (GA3) during the critical period of sugar accumulation in 'Fengtang' plum. …”
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Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study by Gaoyang Li, Shrikant S. Kolan, Franco Grimolizzi, Joseph Sexton, Giulia Malachin, Guro Goll, Tore K. Kvien, Tore K. Kvien, Nina Paulshus Sundlisæter, Manuela Zucknick, Siri Lillegraven, Espen A. Haavardsholm, Espen A. Haavardsholm, Bjørn Steen Skålhegg

“…IntroductionAchieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). …”
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