Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence by Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

“…This study reveals that interactions with A. castellanii modulate C. auris physiology and virulence, contributing to its environmental adaptability and resistance to antifungals.IMPORTANCECandida auris has emerged as a critical public health concern due to its resistance to multiple antifungal drugs and ability to survive on surfaces under harsh conditions, mainly due to biofilm formation. …”
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Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm by Hongguang Yu, Chengao Yang, Yihang Chen, Jianmei Shi, Juntian Cao, Zhengqi Geng, Zhiyuan Wang, Haoran Wen, Enquan Zhang, Yu Zhang, Hao Tan, Donghai Wu, Yingqiang Xu, Haiqiao Ni, Zhichuan Niu

“…The miscibility gap of the InGaAsSb alloy was systematically investigated by calculating the critical temperatures based on the delta lattice parameter model. …”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…To assess the key survival pathways critical for pancreatic cancer progression, we used the AlamarBlue assay to determine synthetic CB1 cannabinoids to induce the cell’s metabolic viability drivers to stage migratory intercellular communication. …”
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Antibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent <i>Klebsiella pneumoniae</i> Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa,... by Azra, Taj Ali Khan, Ihtisham Ul Haq, Woranich Hinthong, Susana Campino, Aisha Gohar, Noman Khan, Muhammad Kashif, Ihsan Ullah, Taane G. Clark

“…The findings of this study underscore the critical need for the active surveillance of antimicrobial resistance and virulence determinants in <i>K. pneumoniae</i>. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…ABSTRACT The human microbiome, the community of microorganisms that reside on and inside the human body, is critically important for health and disease. However, it is influenced by various factors and may vary among individuals residing in distinct geographic regions. …”
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Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…Additionally, ASX enhances the expression of P62 and decreases levels of Beclin1 and microtubule-associated proteins light chain 3 (LC3).ConclusionOur results indicate that ferroptosis and autophagy are critical factors influencing the occurrence and progression of DOX-induced cardiotoxicity. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…YAP (Yes-associated protein) was reported to play a critical role in regulation of aging and resisting oxidative damage, yet these roles had not been elucidated in the placenta. …”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…Together, these results establish that the BMC-mediated metabolism of ethanolamine is critical for fusobacterial virulence.IMPORTANCEThe oral anaerobe Fusobacterium nucleatum can spread to distal internal organs, such as the colon and placenta, thereby promoting the development of colorectal cancer and inducing preterm birth, respectively. …”
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Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study by Humayun Yousaf, Abdul Qadeer, Muhammad Sohail, Maqbool Khan, Muhammad Farooq, Zakir Khan, Dalia Fouad, Yu-Chia Liu, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…ObjectiveThe reappearance of monkeypox in non-endemic countries has preceded critical public health concerns. The public’s adherence to preventative measures is influenced by their understanding of the infectious monkeypox virus (Mpox), attitude toward it, and perceptions of it. …”
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Diversity and Functional Insights into Endophytic Fungi in Halophytes from West Ordos Desert Ecosystems by Xingzhe Wang, Yan Zhang, Jingpeng Li, Yiteng Ding, Xiaodan Ma, Peng Zhang, Haijing Liu, Jie Wei, Yuying Bao

“…Redundancy analysis (RDA) and Mantel tests demonstrated that soil factors such as organic matter, available sulfur, and urease significantly influenced fungal diversity, richness, and evenness, suggesting that soil physicochemical properties play a critical role in regulating fungal–plant symbiosis. …”
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Identifying factors affecting delivery points, risk transfer and costs in international trade with an emphasis on Incoterms 2020 by Morteza Babaie, Firouze Haji Aliakbari, Fereshte Lotfizade, Arshad Farahmandian

“…KIM (2022) argue in a study entitled "Some Critical and Controversial issues abort Incoterms 2020 for International Trade", that Incoterms 2020 provides eleven laws (seven laws for multiple transport and four laws for maritime transport). …”
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Real-world effectiveness of azvudine versus nirmatrelvir-ritonavir in hospitalized patients with COVID-19 and pre-existing diabetes by Guanyue Su, Silin Li, Donghua Zhang, Yongjian Zhou, Ling Wang, Yiqiang Yuan, Guowu Qian, Guotao Li, Na Han, Ming Cheng, Guangming Li, Shixi Zhang, Hong Luo, Mengzhao Yang, Yanyang Zhang, Zhan Song, Jiyuan Xing, Zujiang Yu, Zhigang Ren

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Narratives of swiss football players about talent - and positive youth development: The role of social agents and agency. by Philipp Koch, Bryan Charbonnet, Noora Ronkainen

“…Holt & McDonough, 2024). Both highlight the critical role of proximal social agents within the family (parents, siblings) and the sport subsystem (coaches, peers; Dorsch et al., 2022) while advocating for relational-developmental systems (RDS; Overton, 2015) as a guiding theoretical framework. …”
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The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Since standard skin or blood tests do not always pinpoint the root causes of allergies, identifying new fungal allergens is critical for more precise hypersensitivity diagnoses. …”
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Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study by Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

“…Sentiment analysis revealed notable variations in the way LLMs communicated critical information, underscoring the essential role of neutral and objective health care communication in ensuring that pregnant women, particularly vulnerable during the COVID-19 pandemic, receive accurate and reassuring guidance. …”
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An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study by Guanghao Liu, Shixiang Zheng, Jun He, Zi-Mei Zhang, Ruoqiong Wu, Yingying Yu, Hao Fu, Li Han, Haibo Zhu, Yichang Xu, Huaguo Shao, Haidan Yan, Ting Chen, Xiaopei Shen

“…Early forewarning and diagnosis of SS, which are critical in reducing mortality, are still challenging in clinical management. …”
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Research status and future prospect of carbon capture technology using steel slag in the context of carbon neutrality by Lei AN, Xiaoyuan ZHANG, Yu LIU

“…Dissolution efficiency of carbon dioxide in the liquid phase is equally critical. Therefore, measures that can effectively enhance CO2 solubility, such as micro/nanobubbles and the application of seawater, were proposed. …”
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Analysis of Role of Haematological Parameters in Diagnosis of Grampositive and Gram-negative Urinary Tract Infection: A Case-control Study by Sudha Srinivasan, Ayeesha Sithika Thajudeen, Kundhavai Chandrasekaran, Vijayashree Raghavan, D Roshini

“…Early diagnosis and intervention are critical to preventing complications like pyelonephritis and mitigating the risk of recurrent infections that can lead to permanent scarring. …”
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Good-Quality mHealth Apps for Endometriosis Care: Systematic Search by Diksha Sirohi, Cecilia HM Ng, Niranjan Bidargaddi, Helen Slater, Melissa Parker, M Louise Hull, Rebecca O'Hara

“…However, poor-quality apps can spread misinformation or provide recommendations that are not evidence-based. Therefore, a critical evaluation is needed to assess and recommend good-quality endometriosis mHealth apps. …”
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Assessment of out-of-pocket (OOP) expenditures on essential medicines for acute and chronic illness: a comparative study across regional and socioeconomic groups in India by Ranjit Kumar Dehury, Imteyaz Ahmad, Manas Ranjan Behera, Janmejaya Samal, Varalakshmi Manchana, Jalal Mohammed, Parthsarathi Dehury, Deepanjali Behera, Nafisa Vaz e Desouza, Abhishek Dondapati

“…The odds ratio reveals a critical positive association between high OOP and poor economic status in households in Odisha. …”
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