Suggested Topics within your search.
Suggested Topics within your search.
- History and criticism 21
- Critical Care 8
- History 7
- Criticism 6
- methods 6
- Emergencies 5
- American literature 4
- Child 4
- Cultural property 4
- Historic preservation 4
- Infant 4
- Philosophy 4
- Critical Illness 3
- Critical care medicine 3
- Critical thinking 3
- English literature 3
- Hospitality industry 3
- Information technology 3
- Law 3
- Literature 3
- Nursing 3
- Protection 3
- Psychology 3
- Social service 3
- Study and teaching 3
- Tourism 3
- Anesthesia 2
- Appreciation 2
- Critical Care Nursing 2
- Critical care 2
-
16341
Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar...
Published 2022-06-01“…Introduction Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over the last decade with the emergence of cardioprotective novel agents, but without such data for older drugs, leaving a critical gap in our understanding of the relative effects of T2DM agents on cardiovascular risk.Methods and analysis The large-scale evidence generations across a network of databases for T2DM (LEGEND-T2DM) initiative is a series of systematic, large-scale, multinational, real-world comparative cardiovascular effectiveness and safety studies of all four major second-line anti-hyperglycaemic agents, including sodium–glucose co-transporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, dipeptidyl peptidase-4 inhibitor and sulfonylureas. …”
Get full text
Article -
16342
CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation
Published 2024-12-01“…CircHipk3's dual role in enhancing NLRP3 inflammasome activation and inhibiting autophagy makes it a critical regulator in AAA development and rupture. …”
Get full text
Article -
16343
Polybrominated Dibenzo-p-dioxins/Furans (PBDD/Fs) and Diphenyl Ethers (PBDEs) in the Indoor and Outdoor of Gymnasiums
Published 2022-08-01“…The values didn’t exceed the critical levels when the gym employees and users were assessed by non-cancer and cancer risks of organobromines. …”
Get full text
Article -
16344
Responsible research in health disparities using the Adolescent Brain Cognitive DevelopmentSM (ABCD) study
Published 2025-01-01“…Conclusion: Adolescence is a critical period of development with subsequent ramifications for health outcomes across the lifespan. …”
Get full text
Article -
16345
Molecular uncovering of important helminth species in wild ruminants in the Czech Republic
Published 2025-02-01“…The geographical distribution patterns identified in this study indicate potential hotspots for specific helminth species. These findings are critical for planning health management and conservation strategies to mitigate the impacts of helminth infections, especially in areas affected by invasive species.…”
Get full text
Article -
16346
Integrative analyses of morpho-physiological, biochemical, and transcriptomic reveal the seedling growth response of Pinus yunnanensis to nitrogen and phosphorus fertilization
Published 2025-01-01“…Appropriate nitrogen (N) and phosphorus (P) fertilization is critical for plant growth and production. Pinus yunnanensis, a silvicultural tree in southwestern China, faces economic and ecological limitations due to nutrient deficiency in the soils in its distribution areas. …”
Get full text
Article -
16347
One-step diagnosis of infection and lung cancer using metagenomic sequencing
Published 2025-02-01“…Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious pathogens and tumors simultaneously. However, critical evidence is still lacking regarding its diagnostic performance in distinguishing between pulmonary infections, tumors, and non-infectious, non-tumor conditions in real clinical settings. …”
Get full text
Article -
16348
Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context
Published 2025-03-01“…PRx retained a significant effect on outcome after adjusting for various clinical and monitoring variables. The critical PRx threshold identified were 0.5 for mortality and 0.0 for favourable outcome. …”
Get full text
Article -
16349
Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort study
Published 2025-01-01“…These findings underscore the necessity for screening and addressing sleep issues in women pregnant through assisted IVF/ICSI treatment, to promote their well-being during this critical period.…”
Get full text
Article -
16350
Partial Stereotactic Ablative Radiotherapy Boost Before Conventional Radiotherapy (P‐SABR) for Large (> 5 cm) Unresectable Stage III Nonsmall Cell Lung Cancer
Published 2025-01-01“…Nonetheless, for tumors that are either large in volume or in close proximity to critical organs at risk, the application of SABR to the entire tumor becomes impractical. …”
Get full text
Article -
16351
Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck
Published 2025-01-01“…The median survival time for immunosuppressed individuals ranged from 11 to 21 months, varying based on their particular characteristics, and most critically, on the presence of other malignancies, while that of immunocompetent patients ranged from 18 to 51 months. …”
Get full text
Article -
16352
NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice
Published 2025-01-01“…Deficiencies in apoptosis were evident through altered expression of cysteine-aspartic acid protease 3 (Caspase-3), P53, and B-cell lymphoma-2 (Bcl-2). Furthermore, critical growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and matrix metalloproteinase-9 (MMP-9) were significantly decreased at the excisional skin wound sites. …”
Get full text
Article -
16353
Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon
Published 2025-02-01“…This research underscores the critical role of genomic epidemiology in understanding the origins, evolution, and dissemination of antimicrobial resistance and highlights the need to address poultry as a reservoir for resistant Campylobacter.…”
Get full text
Article -
16354
Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma
Published 2025-01-01“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. …”
Get full text
Article -
16355
Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context
Published 2025-02-01“…Heat-related illness, a critical risk during heatwaves, significantly impacts public health, yet its long-term health effects remain poorly understood. …”
Get full text
Article -
16356
A Program for Master of Science in Environment and Natural Resources (MENR)
Published 2022“…According to UN Sustainable Development Goals (SDG), the Goals and targets will stimulate action over the next 15 years in areas of critical importance for humanity and the planet. It states, “We are determined to end poverty and hunger, in all their forms and dimensions, and to ensure that all human beings can fulfil their potential in dignity and equality and in a healthy environment and determined to protect the planet from degradation, including through sustainable consumption and production, sustainably managing its natural resources and taking urgent action on climate change, so that it can support the need of the present and future generations” Goal 15 is to protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss. …”
Get full text
Other -
16357
Designing the alignment model of petrochemical projects with the country's industrial strategies in the Ministry of Petroleum
Published 2024-06-01“…The proposed framework supports the alignment of project success with organizational goals through critical success factors. Primasari (2022) investigated strategy formulation to achieve alignment between information technology and business in game companies. …”
Get full text
Article -
16358
Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment
Published 2024-12-01“…Cash management is critical for firm value as both cash surpluses and deficits can diminish value. …”
Get full text
Article -
16359
Training Psychological Skills: Efficacy and Assessment of a Nonclinical Psychological Sports Coaching E-Intervention for Young Elite Athletes
Published 2025-01-01“…However, their effectiveness remains uncertain, as scientific validation of these interventions is lacking. Given the critical role of psychological skills in the development of young athletes and the current emphasis on digital and sustainable innovations, the rise of accessible e-interventions is unsurprising. …”
Get full text
Article -
16360
Designing and Explaining the Competence Model of Knowledge Engineers in Municipalities (Study Case: Tehran Municipality)
Published 2024-11-01“…Objective In today's fast-paced organizational environment, effectively managing knowledge is critical to ensure that valuable insights and expertise are not lost when employees leave. …”
Get full text
Article