HDAC10 and its implications in Sézary syndrome pathogenesis by Monika Pieniawska, Karolina Rassek, Bogumiła Skwara, Magdalena Żurawek, Iwona Ziółkowska-Suchanek, Lydia Visser, Monique Lodewijk, Małgorzata Sokołowska-Wojdyło, Małgorzata Sokołowska-Wojdyło, Berenika Olszewska, Roman J. Nowicki, Roman J. Nowicki, Tomasz Stein, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Marta Szymoniak-Lipska, Natalia Rozwadowska, Katarzyna Iżykowska

“…Whole transcriptome analysis indicated that HDAC10 is associated with crucial cancer-related pathways, for example, hematopoietic cell lineage, PI3K-Akt signaling pathway, Ras signaling pathway, MAPK signaling pathway or JAK-STAT signaling pathway, which are critical for the survival and proliferation of malignant T cells. …”
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Collection of microorganisms of ICG SB RAS as a genetic resource for biotechnology by A. V. Bryanskaya, Y. E. Uvarova, A. S. Rozanov, N. M. Slynko, V. N. Shlyakhtun, K. V. Starostin, E. A. Demidov, E. V. Lazareva, O. P. Taran, S. E. Peltek

“…Genetic knowledge of microorganisms plays a critical role in the creation of new biotechnologies, since the effectiveness of any biotechnology is determined by the particular qualities of the structurally functional organization of molecular-genetic systems and their components used for the production of targeted products. …”
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Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…We first demonstrated that the predicted structure retained a high accuracy in critical regions of the extracellular domain and subsequently validated the in-silico mutagenesis methods by evaluating the effects of the strongest risk variant R47H of TREM2. …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…<p>Air quality forecasting plays a critical role in mitigating air pollution. However, current physics-based air pollution predictions encounter challenges in accuracy and spatiotemporal resolution due to limitations in the understanding of atmospheric physical mechanisms, observational constraints, and computational capacity. …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…ATP11B was identified as a potential target of LTX-315 and a critical regulator in maintaining PD-L1 expression in pancreatic cancer cells. …”
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Ebbs and Flows of Marine Biodiversity: Navigating Spatiotemporal Patterns of Environmental DNA in a Coastal Tidal Ecosystem by Michelle Scriver, Ulla vonAmmon, Xavier Pochon, Martin Zirngibl, Francois Audrezet, Kaeden Leonard, Kylie Pedersen, Nick Bamford, Ngairo Tahere, Jo‐Ann L. Stanton, Neil J. Gemmell, Anastasija Zaiko

“…Understanding eDNA dynamics in tidal areas is critical for guiding sampling strategy design and interpreting molecular detection results. …”
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Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment by Haiyi Zhang, Lu Zhang, Juan Lu, Jiajun Yue, Zhengzhen Yuan, Jidan Hu, Qi Yao, Yuting Fu, Guiquan Chen, Jiliang Fang, Jie Zhao

“…The reduced coordination among these functional networks may play a role in the deterioration of cognitive functions and decision-making capabilities, potentially serving as a critical mechanism contributing to the early manifestation of cognitive impairments.…”
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Unlocking barriers and strategies of halal certification for micro and small enterprises in Indonesia: Analytic network process approach by Muhammad Anwar Fathoni, Prima Dwi Priyatno, Faizi, Fadhli Suko Wiryanto, Widarto Rachbini, Suryani

“…Financial support, regulatory reforms, and educational programs emerged as the most critical strategies for overcoming these barriers. …”
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Effect of Bovine Serum Albumin (BSA) Concentration on Cryopreservation of Booroolong Frog Sperm with Evaluation of Post-Thaw Motility in Caffeine by Zara M. Anastas, Aimee J. Silla, Phillip G. Byrne, Rebecca J. Hobbs, Michael S. McFadden, Jonathan Daly, Justine K. O’Brien

“…The aim of this study was twofold: (1) to investigate the effect of the addition of bovine serum albumin (BSA) to the cryopreservation medium (pre-freeze), and (2) the effect of the addition of caffeine to the activation medium (post-thaw), on post-thaw sperm characteristics in the critically endangered Booroolong frog (<i>Litoria booroolongensis</i>). …”
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Optimal multiobjective design of an autonomous hybrid renewable energy system in the Adrar Region, Algeria by Abderrahmane Mehallou, Benalia M’hamdi, Abderrahmane Amari, Madjid Teguar, Abdelaziz Rabehi, Mawloud Guermoui, Amal H. Alharbi, El-Sayed M. El-kenawy, Doaa Sami Khafaga

“…Abstract Extended power outages are not only a nuisance but a critical problem in the modern world, which demands a continuous supply of decent quality electricity. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…Additionally, forty ESBL genes, particularly critical genes such as blaCTX-M and blaNDM-1, were also identified in Salmonella isolates. …”
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Alkaloid Profile, Anticholinesterase and Antioxidant Activities, and Sexual Propagation in <i>Hieronymiella peruviana</i> (Amaryllidaceae) by Olimpia Llalla-Cordova, Javier E. Ortiz, Luciana R. Tallini, Laura Torras-Claveria, Jaume Bastida, Lorena Celina Luna, Gabriela E. Feresin

“…These findings establish <i>H. peruviana</i> as a promising source of bioactive alkaloids with potential pharmacological and therapeutic applications, as well as providing critical insights for its propagation and conservation.…”
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Temperature-Related Bioclimatic Variables Play a Greater Role in the Spatial Distribution of Bumblebee Species in Northern Pakistan by Muhammad Naeem, Arzoo Rani, Weiyao Lyu, Huaibo Zhao, Maryam Riasat, Saail Abbas, Sabir Hussain, Nawaz Haider Bashir, Qiang Li, Huanhuan Chen

“…This study demonstrates the critical influence of temperature on the spatial distribution of bumblebee species in northern Pakistan, underscoring the need for climate-focused conservation strategies to protect these important wild pollinators.…”
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Tigers and Their Prey in Bukit Rimbang Bukit Baling: Abundance Baseline for Effective Wildlife Reserve Management by Febri Anggriawan Widodo, Stephanus Hanny, Eko Hery Satriyo Utomo, Zulfahmi Zulfahmi, Kusdianto Kusdianto, Eka Septayuda, Tugio Tugio, Effendy Panjaitan, Leonardo Subali, Agung Suprianto, Karmila Parakkasi, Nurchalis Fadhli, Wishnu Sukmantoro, Ika Budianti, Sunarto Sunarto

“…Managing the critically endangered Sumatran tiger (Panthera tigris sumatrae) needs accurate information on its abundance and availability of prey at the landscape level. …”
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Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…With rapidly growing coastal communities and increasing demands for fresh groundwater, understanding controls of continental-scale coastal groundwater salinity is critical. To investigate what hydrogeological factors (e.g. topography, hydraulic conductivity) control coastal saline groundwater at continental scales, we have simulated variable-density groundwater flow across North America with the newly developed Global Gradient-based Groundwater Model with variable Densities (G ^3 M-D). …”
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Evaluation of nutrient loads conveyed to the deep subalpine lakes of Northern Italy through their main tributaries by Paolo Dezuanni, Paolo Dezuanni, Diego Copetti, Claudia Dresti, Nicolò Pella, Nicolò Pella, Fabio Buzzi, Andrea Fenocchi, Andrea Fenocchi

“…Nutrient pollution is a critical issue for lakes, leading to cultural eutrophication, which damages the ecosystem and prevents water uses. …”
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Considerations for determining warm-water coral reef tipping points by P. Pearce-Kelly, A. H. Altieri, J. F. Bruno, C. E. Cornwall, M. McField, A. I. Muñiz-Castillo, J. Rocha, R. O. Setter, C. Sheppard, R. M. Roman-Cuesta, C. Yesson

“…These impacts may drive coral ecosystems past critical thresholds, beyond which the system reorganises, often abruptly and potentially irreversibly; this is what the Intergovernmental Panel on Climate Change (IPCC, 2022) define as a tipping point. …”
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Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa by Rieneke Weij, Stephanie E. Baker, Tara R. Edwards, Job Kibii, Georgina Luti, Robyn Pickering

“…We mark this moment in our field by critically reflecting on the role of extractive practices, especially centred around past mining of the Caves and the exclusion of many members of research teams. …”
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Phenotypic and genetic extended spectrum beta lactamase profiles of bacterial isolates from ICU in tertiary level hospital in Kenya [version 2; peer review: 2 approved] by Edwin O. Magomere, Lucy Muchiri, Leon Otieno, Frank G. Onyambu, Ali Kassim, Job Mwale, Brian Maina

“…Background Bacterial infections in the Intensive Care Units are a threat to the lives of critically ill patients. Their vulnerable immunity predisposes them to developing bacteria-associated sepsis, deteriorating their already fragile health. …”
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Evaluation of Rapeseed Leave Segmentation Accuracy Using Binocular Stereo Vision 3D Point Clouds by Lili Zhang, Shuangyue Shi, Muhammad Zain, Binqian Sun, Dongwei Han, Chengming Sun

“…Rapeseed leaves are critical in cultivation and breeding, yet traditional two-dimensional imaging is susceptible to reduced segmentation accuracy due to occlusions between plants. …”
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