A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years by Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny JJ Wang, Xingfeng Shao

“…There is a growing interest in the choroid plexus (ChP) due to its critical role in cerebrospinal fluid (CSF) production and its involvement in neurodegenerative and cerebrovascular diseases. …”
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Life in green: Associations between greenspace availability and mental health over the lifecourse – A 40-year prospective birth cohort study by B. Deng, J. Boden, N. Ye, J. Morgenroth, M. Campbell, P. Eggleton, G. McLeod, M. Hobbs

“…Bayesian Relevant Lifecourse exposure models examined the associations between childhood greenspace availability and adolescent mental health and tested for critical/sensitive age periods. Generalised Estimating Equation logistic regression models assessed the associations between greenspace availability and mental health across adulthood. …”
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The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis by Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

“…Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut microbiome critically contribute to the development of rheumatoid arthritis (RA). …”
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Indications, Surgical Technique and Outcomes of Laparoscopic Splenectomy: A Retrospective Descriptive Study from Srinagar, India by Mushtaq Chalkoo, Mudasir Habib, Ashiq Hussain Raina, Firdous Hamid, Sajad Nazir Malla, Imtiyaz Ahmad Malik

“…Proper planning and a reproducible operative technique are critical for success in laparoscopic splenectomy, even for massive spleens.…”
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Assessing water demand and supply in the Upper Indus Basin using integrated hydrological modeling under varied socioeconomic scenarios by Sareer Ahmad, Muhammad Waseem, Hira Wahab, Abdul Qadeer Khan, Zulqarnain Jehan, Izhar Ahmad, Megersa Kebede Leta

“…The study highlights the critical role of technology and farmer awareness in achieving these reductions, despite current irrigation scheme losses of 20%. …”
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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or tar... by Dongdong Zhang, Guichao Liu, Jinhui Ye, Ke Li, Guojun Zhang, Qiang Quan, Xinhai Zhu, Peng Li

“…Conclusions These findings collectively suggest that circulating Vδ2 T cells with low levels of immune exhaustion are critical contributors to the effectiveness of chemotherapy and targeted therapies in NSCLC. …”
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Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…Finally, 29 DEGs were identified as critical in responding to hypoxia stress and A. veronii infection. …”
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Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study by Ehsan Bitaraf, Seyyed Amir Yasin Ahmadi, Alireza Gandomi-Mohammadabadi, Zahra Noorani Mejareh, Bahare Abdollahi, Javad Balasi, Farzan Moodi, Nima Hemmati, Ali Kabir

“…Regulation of the immune system is critical for fighting against viral infections. Both suppression and hyperactivity of the immune system result in failure of treatment. …”
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Tracking the Prevalence of Antibiotic Resistance in <i>Enterococcus</i> Within the Spanish Poultry Industry: Insights from a One Health Approach by Josep Garcia-Llorens, Isaac Monroy, Jan Torres-Boncompte, Jose M. Soriano, Pablo Catalá-Gregori, Sandra Sevilla-Navarro

“…<b>Conclusions</b>: These findings highlight the critical need for targeted surveillance and intervention strategies in poultry production to mitigate the risks posed by MDR <i>Enterococcus</i> to public health.…”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…Abstract Background Clinical reasoning is a critical skill for healthcare professionals, vital for making accurate diagnoses and effective treatment decisions. …”
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Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…Significance: These findings underscore the critical need for reliable biomarkers in melanoma research, particularly for predicting responses to immune-checkpoint inhibitors (ICIs). …”
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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Rice (<i>Oryza sativa</i> L.) is a staple crop for nearly half of the global population and one of China’s most extensively cultivated cereals. Heading date, a critical agronomic trait, determines the regional and seasonal adaptability of rice varieties. …”
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Genome-wide identification of MGT gene family in soybean (Glycine max) and their expression analyses under magnesium stress conditions by Ammar Anwar, Junaid Akhtar, Saba Aleem, Maida Aleem, Muhammad Khuram Razzaq, Saud Alamri, Qasim Raza, Iram Sharif, Arooj Iftikhar, Shehreen Naseer, Zaheer Ahmed, Iqrar Ahmed Rana, Waheed Arshad, Muhammad Imran Khan, Javaid Akhter Bhat, Muqadas Aleem, Abdel-Rhman Z. Gaafar, Mohamed S. Hodhod

“…Abstract Background Magnesium (Mg) is essential for plant growth and development and plays critical roles in physiological and biochemical processes. …”
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Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment by Quanlong Wu, Mengyin Deng, Ruoyu Mao, Na Yang, Ya Hao, Manli Cao, Da Teng, Jianhua Wang

“…The high-level preparation of PPI45 and PPI47 was achieved with yields of 1.82 g/L and 2.13 g/L, which are 2.19 and 2.60 times the yield of PPI42. Additionally, the critical micelle concentrations (CMCs) of the peptides at pH 7.4 for PPI42, PPI45, and PPI47 were determined to be 245 µg/mL, 973 µg/mL, and 1016 µg/mL, respectively. …”
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LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

“…Recent studies indicate that glycolysis plays a critical role in endothelial cells (ECs)-related diseases. …”
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LURAP1L-AS1 long noncoding RNA promotes breast cancer progression and associates with poor prognosis by Radhakrishnan Vishnubalaji, Dania Awata, Nehad M. Alajez

“…Long noncoding RNAs (lncRNAs) are emerging as critical regulators of cancer biology, yet their roles in breast cancer, particularly in triple-negative breast cancer (TNBC), remain incompletely understood. …”
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The Escalating Magnitude of COVID-19 Infections among the Northeastern Ethiopia Region: A Community-Based Cross-Sectional Study by Zeleke Geto, Saba Gebremichael, Melaku Ashagrie Belete, Alemu Gedefie, Genet Molla, Melkam Tesfaye, Wondmagegn Demsiss, Daniel Gebretsadik

“…It is not hidden that estimating the magnitude of COVID-19 infection from the community surveys is critical for public health policymakers to make decisions to deal with the outbreak, optimize measures, and design mitigation plans. …”
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Regular Antenatal Attendance and Education Influence the Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study at the University Hospital, Ku... by Otchere Addai-Mensah, Max Efui Annani-Akollor, Linda Ahenkorah Fondjo, Kwadwo Sarbeng, Enoch Odame Anto, Eddie-Williams Owiredu, Shanice Nglokie Arthur

“…Conclusion. ANC attendance is critical in IPTp uptake. The results emphasize the need for the Health Policy Makers in Kumasi to encourage pregnant women, especially women working in the formal sector and women having more than four children to patronize ANC attendance to ensure high coverage of the recommended IPTp dose.…”
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MASFNet: Multi-level attention and spatial sampling fusion network for pine wilt disease trees detection by Dong Ren, Meng Li, Ziyu Hong, Li Liu, Jingfeng Huang, Hang Sun, Shun Ren, Pan Sao, Wenbin Wang, Jingcheng Zhang

“…Additionally, we propose a spatial sampling fusion (SSF) module that samples critical sub-regions of features across different layers, generating finer-grained features and thereby enhancing the discrimination between highly similar objects. …”
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Waterbird diversity and its influencing factors in various types of coastal wetlands in the Bohai Rim region by Mengdi FU, Jun WANG, Chunfei HOU, Junsheng LI, Jiade BAI, Yuanyuan ZHANG

“…The coastal wetlands of the Bohai Rim region in China serve as critical habitats for breeding, migratory stopovers, and wintering birds along the East Asian-Australasian Flyway. …”
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