Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

“…DRs are essential for mediating various downstream signaling cascades and play a critical role in regulating the dopaminergic nigrostriatal pathway, which is involved in motor control. …”
Get full text

Predicting bursal-side supraspinatus tendon tears with the acromioclavicular angle by Nadhaporn Saengpetch, Jaturong Bamrungchaowkasem, Niyata Chitrapazt, Pinkawas Kongmalai

“…Existing anatomical parameters, such as the lateral acromion angle, acromial index, and critical shoulder angle, have been studied in relation to rotator cuff tears; however, reliable indicators specific to the risk of bursal-side supraspinatus tears remain lacking. …”
Get full text

Leveraging Deep Learning and Multimodal Large Language Models for Near-Miss Detection Using Crowdsourced Videos by Shadi Jaradat, Mohammed Elhenawy, Huthaifa I. Ashqar, Alexander Paz, Richi Nayak

“…For a deeper analysis, we applied GPT-4o to process critical safety events (near-misses and crashes), utilizing both zero-shot and few-shot learning for narrative generation and feature extraction. …”
Get full text

Effects of manual osteopathic interventions on psychometric and psychophysiological indicators of anxiety, depression and stress in adults: a systematic review and meta-analysis of... by Darren J Edwards, Jerry Draper-Rodi, Danny Miller, Josh Hope-Bell, Andrew MacMillan, Tom C Gordon

“…Risk of bias was assessed using the JBI Critical Appraisal Checklist. For meta-analyses, Hedges’ g (with 95% CIs) was calculated from postintervention means and SD. …”
Get full text

Effects of Different Rates of Poultry Manure and Split Applications of Urea Fertilizer on Soil Chemical Properties, Growth, and Yield of Maize by Aruna Olasekan Adekiya, Oluwaseyi Iyabo Ogunboye, Babatunde Sunday Ewulo, Adeniyi Olayanju

“…Therefore, for better growth and yield of maize, after the initial application of PM, UF application should be split-applied in accordance with plant growth and the pattern of uptake to avoid losses by leaching and therefore ensured that N level in the soil is high at the critical stage of N demand.…”
Get full text

Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex by Ying-Wen Wang, Ching-Wei Luo

“…Mouse models of chronic and acute bone loss followed by biochemical assays and micro-computed tomography demonstrated the bone effects when functionally blocking the critical co-repressor HDAC1. Results Distinct from the TGF-β1 inhibition on adipogenesis through canonical SMAD2/3 signaling, we clarified that TGF-β1 suppresses osteogenesis by inducing the formation of previously unidentified mixed SMADs mainly composed of SMAD1 and SMAD2, in which SMAD2 recruits more TGF-β1-induced co-repressors including HDAC1, TGIF1 and ATF3, whereas SMAD1 allows directing the whole transcriptional suppression complex to the cis-elements of osteogenic genes. …”
Get full text

Efficient Method for Robust Backdoor Detection and Removal in Feature Space Using Clean Data by Donik Vrsnak, Marko Subasic, Sven Loncaric

“…These attacks pose a significant security threat in critical applications, such as street sign or pedestrian recognition for autonomous vehicles, biometric authentication, image retrieval, semantic labeling, etc. …”
Get full text

Synesis as a framework to enable safety interventions in complex healthcare environments by Jamie Cargill, Aarti Bavare, Tiffany Wrenn, Anne Lam, Lauren Salinas, Itode Idowu, Asma Razavi, Venessa Lynn Pinto, Eric Williams

Get full text

Impact of the COVID-19 Pandemic and Vaccine Availability on Utilization of Breast Imaging in a Multistate Radiology Practice by Andrew K. Hillman, Phil Ramis, Patrick Nielsen, Eric M. Rohren

“…We chose March 2020 and December 2020 as critical time points in the pandemic and analyzed trends before and after these dates. …”
Get full text

University proceedings. Volga region. Natural sciences by I.S. Makeev, T.A. Konchina, M.S. Lyubov, O.I. Nedoseko

“…A very high proportion of ruderal species in the floristic and community spectra of the vegetation of the Smirnov Pond, the Shamka stream and the Tesha River (sections No. 3 and No. 4) indicate an intense anthropogenic load caused by both economic transformation and littering of the banks, as well as recreational impact. A critical state of extremely disturbed and replaced by ruderal species of shoreline macrophyte communities has developed in section No. 3 of the Tesha River and No. 6 of the Shamka stream. …”

Fetal-BET: Brain Extraction Tool for Fetal MRI by Razieh Faghihpirayesh, Davood Karimi, Deniz Erdogmus, Ali Gholipour

“…<italic>Goal:</italic> In this study, we address the critical challenge of fetal brain extraction from MRI sequences. …”
Get full text

Field Study on the Law of Surface Subsidence in the High-Intensity Fully Mechanized Caving Mining Working Face with Shallow Thick Bedrock and Thin Epipedon in Hilly Areas by Yi Tan, Hao Cheng, Shuang Gong, Erhu Bai, Minchao Shao, Bingyuan Hao, Xiaoshuang Li, Han Xu

“…According to the field measurement, critical full mining can be achieved in P2 working face when the ratio of mining width to mining depth is 1.07. …”
Get full text

Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

Get full text

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA‐Seq and Bulk RNA‐Seq: A Model Development and Validation Study by Jiaqi Zhang, Shunzhe Song, Yuqing Li, Aixia Gong

“…ABSTRACT Background Altered glucose metabolism is a critical characteristic from the beginning stage of esophageal squamous cell carcinoma (ESCC), and the phenomenon is presented as a pink‐color sign under endoscopy after iodine staining. …”
Get full text

Ghanaian women’s experience of intimate partner violence (IPV) during group antenatal care: a brief report from a cluster randomised controlled trial by Samia J. Abdelnabi, Michelle L. Munro-Kramer, Cheryl A. Moyer, John E.O. Williams, Jody R. Lori

“…However, this study highlights the importance of developing multifaceted approaches to decrease the risk of intimate partner violence among women, especially during the critical times of pregnancy and postpartum. Global health impact for policy and action: Effective global health action and policy must extend beyond educational efforts, incorporating multifaceted strategies that include healthcare provider training, robust community engagement, and legislation aimed at preventing intimate partner violence, with a special focus on safeguarding the well-being of women during pregnancy and the postpartum period.…”
Get full text

Comparative analysis of deep learning models for crack detection in buildings by S. Siva Rama Krishnan, M. K. Nalla Karuppan, Adil O. Khadidos, Alaa O. Khadidos, Shitharth Selvarajan, Saarthak Tandon, Balamurugan Balusamy

“…The development of Artificial Intelligence (AI) techniques, provide favourable solutions in-order to handle, manage and solve building cracks, through analysis using deep image neural network models, that perform classification of the building with crack images. As a result, a critical challenge for many civil engineering applications is the precise, quick, and automated identification of cracks on structural surfaces is addressed with the solutions provided by the deep image neural networks. …”
Get full text

We Walk: a person-centred, dyadic behaviour change intervention to promote physical activity through outdoor walking after stroke—an intervention development study by Stephan U Dombrowski, Brendan McCormack, Maggie Lawrence, Frederike Van Wijck, Jacqui H Morris, Linda A Irvine

“…This study established intervention components and structure and identified operational issues critical to future success. Future research will pilot and refine We Walk and evaluate acceptability, feasibility, effectiveness and cost-effectiveness.Trial registration number ISRCTN34488928.…”
Get full text

Comparative efficacy of acupuncture therapies in premature ovarian failure: A systematic review and network meta-analysis by Yonghang Yi, Fengjun Ma, Yang Jiao, Rongqi Zhang, Yunhao Yi, Yuxia Ma

“…The NMA was conducted using R and STATA software based on frequency theory, focusing on overall effectiveness rates and hormone levels. Additionally, we critically reviewed methodological limitations and potential biases in the studies included. …”
Get full text

Altered Hemodynamics Associated with Pathogenesis of the Vertebral Artery Dissecting Aneurysms by Akira Kurata, Sachio Suzuki, Kazuhisa Iwamoto, Kuniaki Nakahara, Katsutoshi Abe, Madoka Inukai, June Niki, Makoto Sasaki, Kiyotaka Fujii, Shingo Konno, Shinichi Kan, Kazuaki Fukasaku

Get full text

A Dynamic Modeling Approach: Simplifying DFIG Theory, Simulation, and Analysis by Mehmet Dal, Ralph M. Kennel

“…Many technical research problems and critical events that are challenging in DFIG-based WECSs can be studied using the proposed simulation models. …”
Get full text