Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease by David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson

“…These clocks can accurately classify individuals at critical developmental ages in youth (AUROC = 0.953, 0.972, and 0.927, for 15, 18, and 21 years) and capture fine-grained, single-year DNAm signatures of aging that are enriched in biological processes associated with anatomic and neuronal development, immunoregulation, and metabolism. …”
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Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021 by Fassikaw Kebede, Birhanu Kebede, Tsehay Kebede, Melaku Agmasu

“…Undertaking in-depth TB screening and frequent follow-up among all these children is critical in order to prevent and control tuberculosis.…”
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Hybrid Plant Growth: Integrating Stochastic, Empirical, and Optimization Models with Machine Learning for Controlled Environment Agriculture by Nezha Kharraz, István Szabó

“…The role of IoT sensors was critical in enhancing model accuracy and replicability by supplying real-time data on environmental variability. …”
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Brief Report: Precision Language and Deletion of the “S” Word by Ciara Lockstadt, MD, Mary M. Pasquinelli, DNP, Jill Feldman, MD, Jamie L. Studts, PhD, Jamie S. Ostroff, PhD, Li Liu, PhD, Ella A. Kazerooni, MD, Robert A. Smith, PhD, Lisa Carter-Bawa, PhD, Lawrence E. Feldman, MD

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Association between novel anthropometric indices and overactive bladder: a population-based study by Heng Liu, Huqiang Dong, Mingchu Jin, Yu Zhou, Haidong Hao, Yutang Yuan, Hongtao Jia, Min He

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Multi-scale hydraulic graph neural networks for flood modelling by R. Bentivoglio, E. Isufi, S. N. Jonkman, R. Taormina

“…We further corroborate the mSWE-GNN in a realistic case study in the Netherlands and show generalization capabilities with only one fine-tuning sample, with mean absolute errors of 0.12 m for water depth, a critical success index for a water depth threshold of 0.05 m of 87.68 %, and speed-ups of over 700 times. …”
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Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…Chronic inflammation is a critical driver of OC progression, contributing to immune evasion, tumor growth, and metastasis. …”
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Stress assessment instruments for hospitalized preterm newborns: scoping review by Mónica Costa, Maria Filomena Gaspar, Maria Alice Curado, Ana Brantes

“…Conclusion The findings underscore the critical need for stress-specific assessment tools in NICUs to differentiate between pain and stress. …”
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A Structural Model of Truncated Gaussia princeps Luciferase Elucidating the Crucial Catalytic Function of No.76 Arginine towards Coelenterazine Oxidation. by Nan Wu, Zhi-Chao Xu, Kai-Dong Du, Shen Huang, Naohiro Kobayashi, Yutaka Kuroda, Yan-Hong Bai

“…Moreover, R76, a validated activity-critical amino acid residue, resides in the cavity and forms a stable hydrogen bond with CTZ. …”
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Carbon Footprint of Beef Cattle in a Conventional Production System: a Case Study of a Large-Area Farming Enterprise in the Wielkopolska Region by Jerzy Bieńkowski, Radosław Dąbrowicz, Małgorzata Holka, Janusz Jankowiak

“…Knowledge of factors affecting the CF structure allows better identification of critical areas in production processes with high GHG emission potential. …”
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Human Detection and Action Recognition for Search and Rescue in Disasters Using YOLOv3 Algorithm by B. Valarmathi, Jain Kshitij, Rajpurohit Dimple, N. Srinivasa Gupta, Y. Harold Robinson, G. Arulkumaran, Tadesse Mulu

“…The proposed work shows that existing models are inadequate for critical applications like search and rescue, which convinces us to propose a model raised by a pyramidal component extracting SSD in human localization and action recognition. …”
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National Development Banks in Europe – A Contribution to Sustainable Finance by Györgyi Nyikos, Zsuzsanna Kondor

“… Purpose: The paper explains critical changes to investment funding occurred over the past fifteen years in the European Union and explores the added value that National Development Banks create for sustainable finance. …”
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Global Occupational Exposure to Blood and Body Fluids among Healthcare Workers: Systematic Review and Meta-Analysis by Dechasa Adare Mengistu, Gebisa Dirirsa, Elsai Mati, Dinku Mekbib Ayele, Kefelegn Bayu, Wegene Deriba, Fekade Ketema Alemu, Yohannes Mulugeta Demmu, Yohanis Alemeshet Asefa, Abraham Geremew

“…A quality assessment was conducted to determine the relevance of the articles using JBI critical appraisal tools. Furthermore, several steps of assessment and evaluation were taken to select and analyze the relevant articles. …”
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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…This study establishes hTERT as a critical regulator of ferroptotic cell death in pre-B ALL, operating through redox homeostasis, iron metabolism, and lipid peroxidation pathways. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. Subsequently, in vitro experiments confirmed that POSTN knockdown significantly inhibited HeLa cell proliferation, invasion, and enhanced radiosensitivity, while promoting apoptosis. …”
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COVID-safe behaviour before, during and after a youth mass gathering event: a longitudinal cohort study by Tegan Cruwys, Joanne A Rathbone, Mark Stevens, Laura J Ferris

“…These reductions in COVID-safe behaviour were significant and enduring, with all declines persisting at follow-up.Conclusion It is critical that public health messaging and interventions emphasise the risks of disease transmission arising from other attendees who are known to us during mass gathering events, and that such messaging is sustained during and following the event to combat reductions in COVID-safe behaviour.…”
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Enhanced vehicle routing for medical waste management via hybrid deep reinforcement learning and optimization algorithms by Norhan Khallaf, Osama Abd-El Rouf, Abeer D. Algarni, Mohy Hadhoud, Ahmed Kafafy

“…Despite this trade-off, the algorithm’s ability to minimize fleet size while fully utilizing vehicle capacity makes it the optimal choice in scenarios where these factors are critical. This approach not only improved performance but also enhanced environmental sustainability, making it the most effective and challenging solution among all the algorithms used in the study.…”
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Evaluating digital literacy of health professionals in Ethiopian health sectors: A systematic review and meta-analysis. by Alex Ayenew Chereka, Agmasie Damtew Walle, Sisay Yitayih Kassie, Adamu Ambachew Shibabaw, Fikadu Wake Butta, Addisalem Workie Demsash, Mekonnen Kenate Hunde, Abiy Tassew Dubale, Teshome Bekana, Gemeda Wakgari Kitil, Milkias Dugassa Emanu, Mathias Nega Tadesse

“…<h4>Background</h4>Digital literacy refers to the capacity to critically assess digital content, use digital tools in professional settings, and operate digital devices with proficiency. …”
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Potential Modulatory Role of Phoenixin-14 in Epithelial–Mesenchymal Transition of Endometriotic 12Z Cells by Karolina Iwona Kulinska, Magdalena Wierzbicka, Anna Dera-Szymanowska, Krzysztof Szymanowski, Mirosław Andrusiewicz, Maria Wołuń-Cholewa

“…The epithelial–mesenchymal transition (EMT) is critical to endometriosis progression, where cells lose epithelial traits and gain invasiveness. …”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…Identifying and implementing early and adequate therapy are critical for improving clinical outcomes. The burden of JIA on affected children, their families, and the healthcare system in Spain has not been adequately assessed. …”
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