Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…The transcription factors MYB, ERF, bHLH, zinc finger, and MADS-box may regulate the genes involved in hormone signal transduction and starch and sucrose metabolism, which are critical for regulating the transition from endo- to ecodormancy in AMM buds. …”
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Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared... by Simon Gilbody, Caroline Fairhurst, Catherine Hewitt, Dean McMillan, Carolyn Chew-Graham, Della Bailey, David Ekers, Steve Parrott, Elizabeth Littlewood, Peter Coventry, Han-I Wang, Kalpita Baird

“…Background Depression alongside multiple long-term conditions (MLTCs) in older adults poses a critical public health challenge, worsening physical and mental health and increasing healthcare costs. …”
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Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…These findings highlight the vulnerability of mitochondria and critical metabolic pathways, providing insights into the molecular mechanisms of GA toxicity and guiding future studies on mitigating GA-induced liver damage in goslings.…”
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Importance and fitness of family medicine milestone project from America to Taiwan by Shih-Ming Li, Yaw-Wen Chang, Ming-Nan Lin, Chi-Wei Lin, Chyi-Her Lin, Cheng-Chieh Li, Ming-Hwai Lin, Yin-Fan Chang, Zih-Jie Sun, Fang-Yih Liaw, Jaw-Shiun Tsai, Shinn-Jang Hwang, Li-Kuang Chen, Jin-Shang Wu

“…Results In IPA, a total of 72.7% (16/22) of the sub-competencies exhibited high importance and fitness, with a mean score ≥ 4.7; the exceptions were PC-1 (cares for acutely ill or injured patients), MK-2 (critical thinking skills in patient care), SBP-1 (cost-conscious medical care), PBLI-3 (improves systems), PROF-3 (humanism/cultural proficiency), and ICS-4 (utilizes technology). …”
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Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice by Josh Houlton, Lisa Y. Y. Zhou, Deanna Barwick, Emma K. Gowing, Andrew N. Clarkson

“…Interestingly, aged stroke animals outperformed their sham counterparts, suggesting reopening of a critical window for recovery that is being mediated by BDNF.…”
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An international consensus panel on the potential value of Digital Surgery by Anita Patel, Giuseppe Turchetti, Guy Maddern, Ataru Igarashi, Prasanna Sooriakumaran, Gretchen Purcell Jackson, Anastasia Chalkidou, Jamie Erskine, Jean-Christophe Bernhard, Payam Abrishami, Richard Charter, Richard Culbertson, Jo Carol Hiatt, Matthew Lien, Joseph Soon Yau Ng, Koon Ho Rha, Scott Tackett

“…Assessments to consider the value of the entire surgical ecosystem holistically are critical, especially as many digital technologies are likely to interact simultaneously in the operating theatre.…”
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A comparative filling materials study on microstructure and mechanical properties of welded joints of dissimilar Al–Mg–Si alloys using CMT-laser beam oscillation hybrid welding by H.Y. Shen, J.M. Yu, L. Wang, F. Vogel, C.J. Li, H. Nagaumi

“…Strength predictions indicate that solution strengthening is a significant contributor, with values of 50.87 for ER4047 and 31.54 for ER5183, highlighting the critical role of Si as a strengthening agent. While the ER4047 joint exhibited higher predicted strength, it is imperative to address its porosity improvement to mitigate the risk of crack initiation. …”
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Assessing the role of genotype by environment interaction as determinants of maize grain yield and lodging resistance by Haiwang Yue, Tiago Olivoto, Junzhou Bu, Jianwei Wei, Pengcheng Liu, Wei Wu, Maicon Nardino, Xuwen Jiang

“…Results The grain yields of 13 maize hybrids, along with their four critical agronomic parameters, were assessed in the Huang-Huai-Hai Plain of China across 40 locations in eight provinces. …”
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Dynamic recrystallization mechanism of high-strength Mg-Gd-Y-Zn-Mn alloy by hot compression deformation by Yini Lin, Shiming Wu, Yongxin Wang, Hao Chen, Guo Li, Weidong Xie, Guobing Wei, Yan Yang, Xiaodong Peng

“…As the deformation process progresses, the dislocation density of LAGBs continues to increase, reaching the critical point of promoting DRX. On the one hand, the high dislocation density region can serve as a nucleation site for DRX, and on the other hand, its characteristic of high strain storage energy is the driving force for CDRX nucleation. …”
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The iGains4Gains model guides irrigation water conservation and allocation to enhance nexus gains across water, food, carbon emissions, and nature by Bruce Lankford, Nafn Amdar, Matthew McCartney, Tafadzwanashe Mabhaudhi

“…The model addresses two critical questions regarding increased irrigation efficiency. …”
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A Study on Dust Storm Pollution and Source Identification in Northwestern China by Hongfei Meng, Feiteng Wang, Guangzu Bai, Huilin Li

“…Strengthening regional and international cooperation for transboundary dust management is also emphasized as critical for sustainable mitigation efforts. These findings are significant for understanding and predicting the causes, characteristics, and environmental impacts of dust storms in Lanzhou and the Northwestern region.…”
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The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status by Wanjun Yin, Wanjun Yin, Wanjun Yin, Wanjun Yin, Lei Zhang, Lei Zhang, Peng Zhu, Peng Zhu

“…Maternal exposure to an ambient temperature of less than 10°C is a critical index in the eighth gestational month, which may determine the onset of vitamin D supplementation.…”
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Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis by Jie Wang, Dandan Yan, Suna Wang, Aihua Zhao, Xuhong Hou, Xiaojiao Zheng, Jingyi Guo, Li Shen, Yuqian Bao, Wei Jia, Xiangtian Yu, Cheng Hu, Zhenlin Zhang

“…According to the iENA approach, several metabolites had significant abundance and association changes in osteopenia participants, confirming that osteopenia is a critical stage in the development of osteoporosis. …”
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Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya by Kennedy O. Ogolla, Joyce Chebet, Robert M. Waruiru, Peter K. Gathumbi, Paul O. Okumu, Gabriel O. Aboge

“…Mange is a common disease of rabbits globally, and knowledge of efficacy of drugs used in its treatment is critical for effective disease control. The current study evaluated the efficacy of three commonly used therapeutic agents in Kenya against mange. …”
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Inguinal Lymph Node Dissection for Advanced Stages of Plantar Melanoma in a Low-Income Country by Ollo Roland Somé, Malick Diallo, Damien Konkobo, Nassirou Yabré, Valentin Konségré, Issouf Konaté, Sidy Ka

“…Inguinal lymph node dissection (ILND) in these cases plays a critical role in disease-free and overall survival. …”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

“…Understanding historical patterns of forest cover change (FCC) is critical for predicting future trends and informing sustainable management strategies. …”
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Genotyping of extended-spectrum beta-lactamase-producing Escherichia coli isolated from wastewater of dairy farms in East Java, Indonesia by Fidi Nur Aini Eka Puji Dameanti, Sheila Marty Yanestria, Mustofa Helmi Effendi, Hani Plumeriastuti, Wiwiek Tyasningsih, Emmanuel Nnabuike Ugbo, Rahayu Sutrisno, Muhammad Ali Akramsyah Safri

“…Conclusion: The identified molecular profiles underscore dairy farm wastewater as a critical reservoir for antibiotic resistance genes, particularly blaTEM. …”
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Prediction of Soil Organic Carbon Content in <italic>Spartina alterniflora</italic> by Using UAV Multispectral and LiDAR Data by Jiannan He, Yongbin Zhang, Mingyue Liu, Lin Chen, Weidong Man, Hua Fang, Xiang Li, Xuan Yin, Jianping Liang, Wenke Bai, Fuping Li

“…The results show that the following. 1) The prediction accuracy is improved by classifying the data into three types: unlodging <italic>S. alterniflora</italic> (ULSA), lodging <italic>S. alterniflora</italic> (LSA), and mudflats. 2) XGBoost outperformed RF and SVM in accurately predicting SOC content, with <italic>R</italic>²; values of 0.743 for ULSA, 0.731 for LSA, and 0.705 for mudflats; 3) In the XGBoost models constructed for ULSA, LSA, and mudflats, spectral features contributed 75.7&#x0025;, 73.1&#x0025;, and 63.1&#x0025;, respectively, with the normalized difference vegetation index emerging as the most critical spectral feature. Slope aspect (AS) was identified as the most influential topographic feature. 4) The spatial distribution of SOC exhibited marked heterogeneity, with higher SOC content in ULSA and lower in mudflats, demonstrating a gradient of decreasing SOC content from land to sea. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…The GCS score and arterial pH are critical biomarkers for assessing the severity of ANE.…”
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The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study by Banafsheh Darvishi Teli, Meysam Behzadifar, Mania Beiranvand, Aziz Rezapour, Seyed Jafar Ehsanzadeh, Samad Azari, Ahad Bakhtiari, Payam Haghighatfard, Mariano Martini, Maryam Saran, Masoud Behzadifar

“…Enhancing health insurance coverage, providing government subsidies for treatment, and improving healthcare infrastructure to offer advanced diagnostic and treatment options locally are critical steps to alleviate this burden. Early detection and prevention programs can facilitate earlier diagnosis and reduce treatment costs. …”
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