Comprehensive Analysis of <i>blaCTX-M1</i> Gene Expression Alongside <i>iutA</i>, <i>csgA</i>, and <i>kpsMII</i> Virulence Genes in Septicemic <i>Escherichia coli</i> Using Real-Ti... by Mohsen Karbalaei, Mojgan Esmailpour, Valentyn Oksenych, Majid Eslami

“…Monitoring of these genes is critical for developing effective therapeutic strategies. …”
Get full text

Mindfulness-based retreat for mothers of paediatric heart transplant recipients: protocol for a pilot intervention study by Sara Ahola Kohut, Joanna Mitchell, Samantha J Anthony, Taylor Robertson, Heather Telfer, Mirna Seifert-Hansen

“…Given that a mother’s ability to successfully cope with the demands of her caregiving role may be predictive of positive familial psychosocial outcomes, it is critical that maternal coping is assessed and supported in paediatric healthcare. …”
Get full text

The Addis Declaration on Immunization: Assessing the Effectiveness and Efficiency of Immunization Service Delivery Systems in Africa as of the End of 2023 by Franck Mboussou, Charles Shey Wiysonge, Bridget Farham, Ado Bwaka, Sarah Wanyoike, Amos Petu, Sidy Ndiaye, Andre Bita Fouda, Johnson Muluh Ticha, Adidja Amani, Regis Obiang, Magaran Monzon Bagayoko, Benido Impouma

“…<b>Conclusions</b>: It is critical, as a follow up to this study, to document best practices from the seven countries that achieved the fourth ADI commitment. …”
Get full text

Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Abstract Epithelial-to-mesenchymal transition (EMT) is a critical and complex process involved in normal embryonic development, tissue regeneration, and tumor progression. …”
Get full text

Development of a novel strategy for the quantification of ultra-trace impurity elements in high-purity magnesium using inductively coupled plasma tandem mass spectrometry by Liang Fu, Guangsheng Huang, Yaobo Hu, Xianhua Chen, Jingfeng Wang, Fusheng Pan

“…Impurities in high-purity magnesium affect material properties, which has become the most critical factor restricting its application. However, accurate analysis of multiple ultra-trace impurity elements in high-purity magnesium is extremely challenging. …”
Get full text

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…The co-crystal structures of PLpro with lead compounds reveal that the residues D164 and Q269 around the S2 site are critical for improving the inhibitor’s potency. The lead compound GZNL-P36 not only inhibits SARS-CoV-2 and its variants at the cellular level with EC50 ranging from 58.2 nM to 306.2 nM, but also inhibits HCoV-NL63 and HCoV-229E with EC50 of 81.6 nM and 2.66 μM, respectively. …”
Get full text

Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer by Qinyuan Gong, Qinyuan Gong, Rongzhen Xu, Rongzhen Xu

“…Immune dysfunction is one of the hallmarks of cancer and plays critical roles in immunotherapy resistance, but there is no serum biomarker that can be used to evaluate immune-dysfunction status of cancer patients. …”
Get full text

The Impact of Violations of Bicycles and Pedestrians on Vehicle Emissions at Signalized Intersections by Jianchang Huang, Guohua Song, Jianbo Zhang, Chenxu Li, Qiumei Liu, Lei Yu

“…And frequent violations such as running the red light have been a critical social problem at signalized intersections in developing countries. …”
Get full text

Influence of the polysaccharide capsule on virulence and fitness of Klebsiella pneumoniae by Lisa Zierke, Rodi Mourad, Thomas P. Kohler, Mathias Müsken, Sven Hammerschmidt

“…IntroductionThe capsular polysaccharide (CPS) of pathogenic bacteria is a critical virulence factor, often evading phagocytosis by host immune cells, while also interfering with the contact of the pathogen with host cells and contributing to biofilm formation. …”
Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. …”
Get full text

Microstructural optimization by two-step tempering treatment and quantitative analysis of microstructure effect on the toughness at −40 °C in CrNiMoV steel by Li Wang, Junwei Qin, Yuzhi Zhu, Kaixuan Chen, Yanlin Wang, Zidong Wang

“…30CrNiMoV steel is widely used in engineering applications, where, in addition to high strength requirements, the demand for enhanced toughness is increasingly critical for safety. This study proposes a novel two-step tempering process that optimizes the microstructure by shortening tempering time and accelerating cooling, effectively avoiding the strength-ductility trade-off. …”
Get full text

Implementing regional blue economy research and innovation strategies: a case study for the Black Sea by Baris Salihoglu, Baris Salihoglu, Mustafa Yücel, Pinar Uygurer, Ezgi Şahin Yücel, Evangelos Papathanassiou, Devrim Tezcan, Adrian Stanica, Irina Stanciu, Snejana Petrova Moncheva, Nina Dzhembekova, Kremena Blagovestova Stefanova, Viktor Komorin, Tudor Castravet, Kakhaber Bilashvili, Valerian Melikidze, Mamuka Gvilava, Salome Kobaidze

“…Improved knowledge and enhanced infrastructure together with better coordination and alignment of research and innovation efforts are critical for the better management of the deteriorated Black Sea ecosystem to help restore and maintain its resilience and enable sustainable use of natural resources. …”
Get full text

An Interdisciplinary Analysis of the Late Islamic Cemeteries Within the Cathedral (15th–18th Century CE) and the Ruins of Adulis (Mid-19th–Early 20th Century CE), Massawa, Eritrea:... by Omar Larentis, Nelly Cattaneo, Paolo Lampugnani, Susanna Bortolotto, Emanuele Zappa, Andrea Gregorini, Yotam Gezae, Tsegai Medin, Ilaria Gorini, Serena Massa

“…The Muslim cemeteries of Adulis represent the most extensively investigated Muslim burial site in recent years, providing critical insights into the historical Muslim presence in the region. …”
Get full text

Teachers’ responses to racism and racist bullying in Dutch primary schools by Karen M. A. Sieben-Aduful, Roy A. Willems, Trijntje Völlink, Nico van der Wiel, Maria Sapouna, Pieter de Bruijn, Gemma Blok, Gemma Blok, Arjan E. R. Bos, Arjan E. R. Bos, Giel van Lankveld

“…Further, the results implicate that a pro-active approach can stimulate teachers to critically reflect on their own racial identity, and on school methods, teaching resources and policies concerning racism.…”
Get full text

Research trends and prospects in global riverine carbon fluxes: A bibliometric analysis by Wei Fang, Mohd Remy Rozainy Mohd Arif Zainol, Xianbao Zha, Pingping Luo

“…Rivers are critical conduits of transporting and transforming carbon from land to coastal margins. …”
Get full text

A medical insurance fund operation performance evaluation system under the DRG payment mode reform by Zijian Wang, Zijian Wang, Zijian Wang, Weifu Chang, Weifu Chang, Aijing Luo, Aijing Luo, Aijing Luo

“…BackgroundAn evaluation system for comprehensively measuring medical insurance fund operational performance under China’s Diagnosis Related Groups (DRG) payment reform holds critical theoretical and practical significance, especially for enhancing the efficiency of medical insurance fund utilization and the quality of healthcare services. …”
Get full text

Assessing the Direct Impact of Typhoons on Vegetation Canopy Structure and Photosynthesis by Yaoyao Zheng, Simin Zhan, Zaichun Zhu, Sen Cao, Jiana Chen, Pengjun Zhao, Weimin Wang, Ranga B. Myneni

“…These ecosystems provide critical ecological, social, and economic functions, making accurate assessment of typhoon impacts essential for effective management and disaster risk reduction. …”
Get full text

Centroid-AME: An open-source software for estimating avian migration trajectories using population centroids movement in the annual cycle by Shi Feng, Alice C. Hughes, Qinmin Yang, Leyi Li, Chao Li

“…Migration is a critical aspect of many birds' annual life cycles, with up to 40 % of bird species engaging in migratory behavior. …”
Get full text

Prevalence, antibiotic resistance patterns, and virulence factors of Staphylococcus aureus isolates associated with bovine mastitis in northern Bangladesh by Md. Mominul Islam, Md. Imran Hossain, Md. Sadequl Islam, Md. Golam Azam, Sajeda Sultana

“…These findings underscore the critical importance of implementing stringent antimicrobial stewardship practices and surveillance measures in dairy farming to mitigate the dissemination of antibiotic resistance.…”
Get full text

Integrating Drone Truthing and Functional Classification of Remote Sensing Time Series for Supervised Vegetation Mapping by Giacomo Quattrini, Simone Pesaresi, Nicole Hofmann, Adriano Mancini, Simona Casavecchia

“…Unlike traditional ground truthing activities, drone truthing enabled the generation of large, spatially balanced reference datasets, which are critical for machine learning classification systems. …”
Get full text