Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview by Maciej Rutkiewicz, Sabina Przygodzka, Katarzyna Gadżała, Karolina Garbino, Katarzyna Brudniak, Antoni Szuścik, Magdalena Czyczerska

“…First of all, patients should know what to do to reduce LDL-C levels. Education is critical for understanding the problem and creating a successful course. …”
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Developing a master of science in health research ethics program in Northern Nigeria: a needs assessment by Caitlin Bieniek, Fatimah I. Tsiga-Ahmed, Aishatu L. Adamu, Usman J. Wudil, C. William Wester, Zubairu Iliyasu, Muktar H. Aliyu, Elisa J. Gordon, Elizabeth S. Rose

“…They emphasized that the curriculum should be developed with an interdisciplinary lens and locally contextualized, and that students should be taught how to think critically through ethical scenarios. Respondents stressed that program leaders should recruit faculty and students locally who have the bandwidth to participate in the program. …”
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Fully automatic reconstruction of prostate high-dose-rate brachytherapy interstitial needles using two-phase deep learning-based segmentation and object tracking algorithms by Mohammad Mahdi Moradi, Zahra Siavashpour, Soheib Takhtardeshir, Eman Showkatian, Ramin Jaberi, Reza Ghaderi, Bahram Mofid, Farzad Taghizadeh-Hesary

“…The critical aspect of successful brachytherapy (BT) is accurate detection of applicator/needle trajectories, which is an ongoing challenge. …”
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Clinical outcomes of dogs with high-grade cutaneous mast cell tumors by Siew Mei Ong, Siew Mei Ong, Charly McKenna, Christopher Pinard, Christopher Pinard, Christopher Pinard, Christopher Pinard, Danielle Richardson, Michelle L. Oblak

“…The limited therapeutic benefit of locoregional lymph node extirpation, combined with a persistently high metastatic rate despite systemic chemotherapy, highlights the critical need for more effective regional and systemic treatment approaches for HGMCT patients.…”
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Predictive biomarkers for cardiometabolic risk in postmenopausal women: insights into visfatin, adropin, and adiponectin by Anna Maria Cybulska, Daria Schneider-Matyka, Ireneusz Walaszek, Mariusz Panczyk, Dorota Ćwiek, Anna Lubkowska, Elżbieta Grochans, Kamila Rachubińska, Katarzyna Malewicz, Mariusz Chabowski, Mariusz Chabowski

“…The selection of visfatin, adropin, and adiponectin as biomarkers is based on their significant roles in metabolic regulation and inflammation, which are critical factors in cardiometabolic risk. Visfatin is known for its pro-inflammatory properties and its ability to modulate insulin resistance. …”
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Current status and development trends of deep coalbed methane research in China by Wei JU, Shu TAO, Zhaobiao YANG, Jiayao CHENG, Haiyan SHANG, Weike NING, Chunlong WU

“…Conducting geology and engineering integrated research for deep CBM exploration and development, based on the quantitative characterization of geological and engineering parameters and using three-dimensional geological and geomechanical modeling, is a critical pathway to ensuring profitable development. …”
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Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer by Maria Elena Lacruz, Saskia Thies, Andrea Schmidt-Pokrzywniak, Ian Wittenberg, Tobias Engler, Fabian Reinwald, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Bianca Franke, Kerstin Weitmann, Atanas Ignatov

“…While metastatic behaviour, treatment and long-term response in HER2-low were comparable to HER2-zero, the hormone receptor status seems to play a critical role in these outcomes.…”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Incorporating the expectation that coral cryptic taxa with incomplete species boundaries will frequently be encountered is critical to the long-term success of coral conservation and restoration programs. …”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…Sodium arsenite (NaAsO2), the most common form of inorganic arsenic prevalent in the environment, has been closely linked to islet β-cell dysfunction, a critical pathological hallmark of type 2 diabetes (T2D). …”
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Sustainable closed-loop supply chain network design: heuristic hybrid approach with considering inflation and carbon emission policies by Saeid Kalantari, Hamed Kazemipoor, Farzad Movahedi Sobhani, Seyyed Mohammad Hadji Molana

“…Purpose: Establishing the structure and expansion of sustainable closed-loop supply chains is critical to meeting environmental, economic, and social standards to strengthen their position in competitive markets. …”
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Optimizing Phaeodactylum tricornutum cultivation: integrated strategies for enhancing biomass, lipid, and fucoxanthin production by Mostafa E. Elshobary, Walaa A. Abo-Shanab, Stephan S. W. Ende, Mohammed Alquraishi, Rania A. El-Shenody

“…These findings demonstrate the critical role of precise cultivation conditions in optimizing microalgal metabolic performance for biotechnological applications.…”
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Cephalometric and Photographic Evaluation of the Nasolabial Angle in Orthodontically Treated Patients: An Observational Cohort Study by Silvia Izabella Pop, Eugen Bud, Krisztina Mártha, Izabella Éva Mureșan, Kinga Mária Jánosi, Boglárka Dósa, Bernadette Kerekes-Máthé

“…<b>Background:</b> The nasolabial angle (NLA) is one of the most critical parameters of the soft tissue profile when orthodontic treatment is required. …”
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Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists by Oghenebrume Wariri, Patience Toyin-Thomas, Itua C.G. Akhirevbulu, Oladapo Oladeinde, Oluchi Omogbai, Philippa Odika, John Osakue, Avwebo Ukueku, Efetobo Orikpete, Chinelo Iwegim, Efe E. Omoyibo, Jermaine Okpere, Uwaila Otakhoigbogie, Ekhosuehi T. Agho, Sunday C. Madubueze, Nnennaya C. Ugoji, Chukwunwike W. Ozegbe, Oti N. Aria, Paul Ikhurionan

“…Background Nigeria faces a critical shortage of healthcare professionals yet experiences a significant annual exodus of doctors and dentists. …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…The conversion of fibroblasts to myofibroblasts is known to play a critical role in HS formation, making it essential to identify molecules that promote myofibroblast dedifferentiation and to elucidate their underlying mechanisms. …”
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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis by Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng

“…Abstract Background Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. …”
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Effect of dietary starch inclusion, feeding level and their combination on nutrient digestibility, bile acid balance, faecal waste production and characteristics of yellowtail king... by Yaqing Zhang, Roel M. Maas, Peter Horstmann Zuther, Jeroen Kals, Satya Prakash, Thomas W.O. Staessen, Fotini Kokou, Johan W. Schrama

“…High dietary starch levels resulted in increased faecal waste production, and higher amounts of non-removed faeces by settling due to reduced faecal removal efficiency. The critical dietary starch content was estimated to be 6 %. …”
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Coronary Angiography Safety between Transradial and Transfemoral Access by Santosh Kumar Sinha, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Mohammad Asif, Ramesh Thakur, Chandra Mohan Varma

“…The aim of study was to evaluate safety, feasibility, and procedural variables of transradial approach compared with transfemoral approach in a standard population of patients undergoing coronary catheterization as one of the major criticisms of the transradial approach is that it takes longer overall procedure and fluoroscopy time, thereby causing more radiation exposure. …”
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Multiple Dimensions Define Thresholds for Population Resilience of the Eastern Oyster, Crassostrea virginica by Megan K. La Peyre, Hongqing Wang, Shaye E. Sable, Wei Wu, Bin Li, Devin Comba, Carlos Perez, Melanie Bates, Lauren M. Swam

“…Two statistical approaches were applied, with each model highlighting a different operational definition of a threshold: random forest models identified a threshold as an abrupt change in the oyster abundance‐ salinity relationship, while Bayesian models identified an increased probability of oyster abundance dropping below a critical threshold, defined here as less than 50% of the 5‐year mean. …”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…Our optimization of acid cleavage temperature, duration, and isoelectric precipitation conditions proved critical for maximizing the purification efficiency and expression levels of Kiadin. …”
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Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. …”
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