Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Secretory phospholipase A2 (sPLA2), an inflammatory enzyme, plays a critical role in producing platelet-activating factor (PAF), a key mediator of vascular leak. …”
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Rapid Landslide Detection Following an Extreme Rainfall Event Using Remote Sensing Indices, Synthetic Aperture Radar Imagery, and Probabilistic Methods by Aikaterini-Alexandra Chrysafi, Paraskevas Tsangaratos, Ioanna Ilia, Wei Chen

“…The rapid detection of landslide phenomena that may be triggered by extreme rainfall events is a critical point concerning timely response and the implementation of mitigation measures. …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…This study endeavors to address this critical need by focusing on the design and synthesis of a series of novel compounds. …”
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Exploring the link between soil health and crop productivity by Yingying Xing, Xiukang Wang, Adnan Mustafa

“…Understanding the complex interactions of plants and soils in the face of global food security and environmental degradation challenges is critical to the future of sustainable agriculture. …”
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Predictive models for the surface roughness and subsurface damage depth of semiconductor materials in precision grinding by Shang Gao, Haoxiang Wang, Han Huang, Zhigang Dong, Renke Kang

“…Additionally, this study identifies variations in elastic recovery and material plasticity as critical factors influencing surface roughness and SDD across different materials. …”
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Impact of maternal age on birth weight-related adverse outcomes in newborns: a retrospective study in south-central China by Zhi Huang, Yan Zhang, Jinlian Wang, Xia Tan, Aiping Zhang

“…Abstract Background Birth weight is a critical indicator for assessing fetal development and newborn health status. …”
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Risk assessment for non-carcinogenic effect posed by sulfates in water on the health of residents around The Sumpur River, West Sumatra-Indonesia by Sukarjo, Rahmah Dewi Yustika, Cicik Oktasari Handayani, Triyani Dewi, Yustiawati, Delvi Yanti, Ai Dariah

“…Present study intends to assess the risks posed by sulfate contamination to human health, given its critical implications for water quality in the area. …”
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Urban landscape patterns and residents’ perceptions of safety under extreme city flood disasters by Wei Ma, Yingjie Du, Yuxiao Wang, Quanxiu Chen, Huaxiong Jiang, Runting Cai, Tianshun Gu, Wenxin Zhang

“…Conclusions: This study offers a new perspective on the relationship between ULP and RPS, emphasizing the critical role of flood response strategies tailored to ULP differences in enhancing RPS.…”
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Molecular insights into the functional role of PbNRT2.4 in potassium homeostasis and nutrient transport in Pyrus ussuriensis by Han Yang, Hao Xu, Yujie Shi, Liyan Chen, Lijuan Zhang, Liping Kan, Yumeng Jin, Xinlan Mei, Yangchun Xu, Nazir Ahmed, Caixia Dong

“…Potassium (K), often referred to as the ‘quality element’, is essential for nutrient absorption in fruit trees, with the efficiency of the rootstock's nutrient utilization being a critical factor in the plant's overall nutrient status. …”
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Clinical Management and Surgical Outcomes of Wandering Spleen with Splenic Torsion in Pediatric Patients: A Case Report by Shaban Memeti, Saimir Kuci, Toni Ristevski, Lazar Todorovic, Marijan Kamilovski, Blagica Krsteska, Haris Sulejmani

“…This case highlights the critical need for early diagnosis and timely surgical intervention in cases of wandering Spleen to prevent serious complications, including splenic infarction. …”
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A Framework for Developing Biodiversity Conservation Networks Based on Morphological Spatial Pattern Analysis and the Maximum Entropy Model: A Case Study of the Jianghan Plain, Chi... by Xiaohua Guo, Chang Liu, Shibo Bi, Xuewen Zhang

“…Our findings indicated the following: (1) The Jianghan Plain hosts 21 major ecological sources, primarily natural water bodies at the plain’s edge, which can be classified into five primary and 16 secondary sources based on biodiversity grades. (2) The recessive corridors, comprising 10 primary and 95 secondary ones, are mainly concentrated in the central Jianghan Plain, with primary corridors located centrally and westward, characterized by a large overall span. (3) Changhu Lake and Honghu Lake, two critical water bodies with high-quality habitats and significant biodiversity, were identified as key ecological nodes from the ecological sources, bridging and guiding the central and southern corridors. (4) Based on the ecological network distribution and key nodes and corridors, a “three zones, three belts, and two points” strategy was proposed for optimizing the Jianghan Plain’s ecological network. …”
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Cross-Regional Capacity Mechanism for Emergency Power Support in Extreme Weather Events by WU Zifeng, YUAN Jiahai, ZHANG Jian, ZHANG Haonan

“…Based on cross-regional supply and demand theory，the architectural design of the cross-regional capacity mechanism is enhanced by incorporating three critical components： mechanism boundaries and regulations，lower and upper bounds of the capacity compensation price，and frameworks for responsibility and penalties. …”
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Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Objectives Functional impairment is an early stage of disability, and timely identification and intervention are critical for the health of older adults. However, little is known about the functional impairment of Chinese older adults due to the absence of specialised assessment tools. …”
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Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis by Ali Tadayon, Javad Moayedi, Mohamad Ali Nazarinia, Mahyar Malekzadeh, Sara Kazemi, Maryam Mardani

“…Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by T helper 17 (Th17) cells, and plays a critical role in many inflammatory conditions. This study aims to assess the salivary IL-17 levels in Iranian patients with SSc. …”
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CHOLINE TRANSPORTER-RELATED 4 (CTR4) Is Involved in Drought and Saline Tolerance in Rice by Yu Shicong, Luo Ruxian, Zheng Shuqin, Ning Jing, Shi Yuanzhu, Guo Daiming, Jia Liangmeng, Wang Sen, Xiao Guizong, Guo Pengwang, Li Yang, Ma Xiaoding

“…Using MutMap sequencing, we characterized the role of a choline transporter-related family gene, CTR4 (Choline Transporter-Related 4), in rice’s tolerance to drought and salt stress. CTR4 plays a critical role in regulating membrane lipid synthesis. …”
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The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis by Paulina Marona, Rafał Myrczek, Iga Piasecka, Judyta Gorka, Oliwia Kwapisz, Ewelina Pospiech, Janusz Rys, Jolanta Jura, Katarzyna Miekus

“…These findings highlight the critical role of MCPIP1 RNase activity in modulating the c-Met/CD44 axis, thereby influencing stemness and tumorigenesis.…”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…IL-6-inducing peptides are critical for the development of immunotherapy and diagnostic biomarkers for some diseases. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…Notably, C. auris is classified in the critical priority group on the World Health Organization's fungal priority pathogens list, which highlights fungal species capable of causing systemic infections with significant mortality and morbidity risks as well as the challenges posed by their MDR profiles, limited treatment and management options. …”
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Recurrent Thymic Carcinoma Treated With Median Sternotomy, Innominate Vein Replacement for Superior Vena Cava, and Iodide Implantation: A Case Report and Review of the Literature by Zhong‐zheng Chen, Wen‐dong Qu, Xing‐shu Zhang, Yong‐xiang Song

“…These tumors can exhibit aggressive behavior and may involve surrounding critical structures, such as the superior vena cava. …”
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New Data on Breeding Strategies and Reproductive Success of the Globally Threatened Turtle Dove Co-Occurring with the “Competitive” Collared Dove and the “Predatory” Maghreb Magpie... by Wafae Squalli, Ismail Mansouri, Driss Ousaaid, Mohammed Hmidani, Hamid Achiban, Fatima Fadil, Mohamed Dakki

“…Interactions between co-occurring species, including competition and predation, comprise critical processes regulating local community structure, habitat use, and diversity. …”
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