Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase by Hyun Gyu Lim, Ye Gao, Kevin Rychel, Cameron Lamoureux, Xuwen A. Lou, Bernhard O. Palsson

“…This study demonstrates how the combination of genome-scale datasets and new data analytics reveals the fundamental characteristics of a key transition in the life cycle of bacteria.IMPORTANCENutrient limitations are critical environmental perturbations in bacterial physiology. …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…Further, we elucidate the critical role of FGF signaling in odontoblast maturation and its biomineralization capacity using the de novo designed FGFR1/2c isoform specific minibinder scaffolded as a C6 oligomer that acts as a pathway agonist. …”
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Risk assessment of fine particulate matter exposure attributed to the presence of the cement industry by A. Mallongi, S. Stang, R.D.P. Astuti, A.U. Rauf, M.F. Natsir

“…This new approach determines the critical factors with major effects on reducing the health risk of the vulnerable population.CONCLUSION: Fine particulate matter poses health risks to adults and children, despite the calculated risks are still acceptable. …”
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Experimental Studies on Shale Cracks and Permeability Evolution Based on Acoustic Emission Monitoring by Hao Chen, Hongkui Ge, Xiaoqiong Wang, Jianbo Wang, Shan Wu

“…Results show that porosity has little influence on the permeability before and after loading, while the propagation and connection of cracks are the most critical factors. As the loading stress increases, the crack volume and sample connectivity both grow. …”
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Point prevalence survey of antibiotics in a pediatric tertiary hospital in the Republic of Panama by Ximena Norero, Dora Estripeaut, Elizabeth Castaño, Jacqueline Levy, Paola Lichtenberger, José Pablo Díaz-Madriz, José Luis Bustos, Robin Rojas Cortés, Gabriel Levy-Hara

“…The findings suggest it is necessary to assess the need for ampicillin, gentamicin, and piperacillin-tazobactam use in patients admitted to pediatric critical care units, with special emphasis on children with pneumonia and sepsis diagnosis, the most common pathologies for which an antimicrobial was prescribed.…”
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Risk assessment of look‒alike, sound‒alike (LASA) medication errors in an Italian hospital pharmacy: A model based on the ‘Failure Mode and Effect Analysis’ by Nestor Ciociano, Lucilla Grisi, Lucia Bagnasco, Maria Giovanna Elberti, Marcello Mazzarella

“…The highest ranked failure modes, with an RPN score of 48 pertained to wrong drug dosage selection. Some of the critical failure modes in sample processing (phases n.1, 2, 3, and 4) were improved by 69.7% in the RPN by focusing on automated technology systems. …”
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Seasonal Changes in Climate Variables in Rainfed Crop Areas in the Lerma-Chapala-Santiago Basin, Mexico by Raymundo Ordoñez-Sierra, Miguel A. Gómez-Albores, Carlos Díaz-Delgado, Luis Ricardo Manzano-Solís, Angel Rolando Endara-Agramont, Carlos Alberto Mastachi-Loza

“…Additionally, rainfall showed an annual decrease of approximately 50 mm in all RCAs, which can affect the phenological development of crops during critical stages (emergence through flowering). These changes represent a significant threat to the regional economy and food security of Mexico.…”
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Interactions of Self-Assembled <i>Bletilla Striata</i> Polysaccharide Nanoparticles with Bovine Serum Albumin and Biodistribution of Its Docetaxel-Loaded Nanoparticles by Guangyuan Zhang, Jin Qiao, Xin Liu, Yuran Liu, Ji Wu, Long Huang, Danyang Ji, Qingxiang Guan

“…The results demonstrated that the DS increase of the hydrophobic stearic acid segment increased the negative charge, encapsulation efficiency, and drug-loading capacity while decreasing the critical aggregation concentration value as well as the release rate of docetaxel from the nanoparticles. …”
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Harnessing Meta-Reinforcement Learning for Enhanced Tracking in Geofencing Systems by Alireza Famili, Shihua Sun, Tolga Atalay, Angelos Stavrou

“…Effective geofencing relies heavily on precise tracking capabilities, a critical component for maintaining the integrity and functionality of these systems. …”
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Strategic SWOT analysis of the University of Nigeria Teaching Hospital using Modified Delphi Technique: implications for strengthening national and regional health systems by Cyril Chukwudi Dim, Chinyere Ojiugo Mbachu, Nympha Onyinye Enebe, Wilson Chukwukasi Kassy, Johnpaul Ejikeme Nnagbo, Ikechukwu Emmanuel Obi, Nkiruka Pauline Onodugo, Nwamaka Ngozika Lasebikan, Obinna Donatus Onodugo

“…Following these changes, an Organizational Capacity Assessment (OCA) is critical to direct further development in the organization. …”
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Characterisation of Fourteen Accessions of Trichosanthes cucumerina from Nigeria Using Internal Transcribed Spacer by Ann Osuagwu, Celestine Uzoma Aguoru, Lucky Osabuohien Omoigui, Joseph Olalekan Olasan

“…These have given scientists critical knowledge regarding T. cucumerina molecular breeding in Nigeria.…”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…If successful, the REASSESS study could demonstrate that reduction of ICH volume is a critical target to reduce the risk of progressive cognitive decline, establish targets for residual haematoma volume reduction and determine if greater residual haematoma volume leads to a long-term inflammatory state.Ethics and dissemination Approval of this study was obtained from the Johns Hopkins University Institutional Review Board (IRB00311985). …”
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Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis by Liu Haibo, Luo Shicheng, Sha Xiaofeng, Chen Zhiping, Yang Dongdong

“…Cancer-associated fibroblasts (CAFs) play critical roles in the tumor microenvironment and exert tumor-promoting or tumor-retarding effects on cancer development. …”
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Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life by Urszula Religioni, Rocío Barrios-Rodríguez, Pilar Requena, Mariola Borowska, Janusz Ostrowski

“…This review highlights the profound influence of adherence on clinical outcomes, healthcare costs, and patient quality of life. Despite its critical importance, non-adherence remains a pervasive challenge globally, contributing to suboptimal treatment results, higher rates of complications, increased hospitalizations, and substantial healthcare expenditures. …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…Given their role in disease transmission, accurate identification of horse fly species is critical but traditionally relies on morphological characteristics, requiring significant expertise and posing a high potential for error, especially with damaged specimens. …”
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Environmental Governance Challenges of Indigenous Forest Recognition: Climate Solution Ideal and Its Uneven Outcomes in Indonesia by Abdurrahman Abdullah, Micah R. Fisher, Muhammad Alif K. Sahide

“…We apply a lens from political ecology and draw from critical research on land and property to identify the unevenness of an emerging climate policy solution. …”
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Simulation analysis of radiometer effect and outgassing based on molecular particle source perturbation by Wenyan Zhang, Zuolei Wang, Jian Min, Yi Wang, Jungang Lei, Yunpeng Li, Dongxue Xi

“…Abstract The Laser Interferometer Space Antenna (LISA) mission is designed to detect space gravitational wave sources in the millihertz band. A critical factor in the success of this mission is the residual acceleration noise metric of the internal test mass (TM) within the ultra-precise inertial sensors. …”
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The Influence of Resin Infiltration on the Shear Bond Strength of Orthodontic Brackets: A Systematic Review and Meta-Analysis by Sylwia Kiryk, Jan Kiryk, Jacek Matys, Maciej Dobrzyński

“…The quality of the enamel plays a critical role in the retention and performance of orthodontic brackets. …”
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Robust Time-Series InSAR Deformation Monitoring by Integrating Variational Mode Decomposition and Gated Recurrent Units by Peifeng Ma, Zeyu Jiao, Zherong Wu

“…Continuous and large-scale surface deformation monitoring is critical for the comprehension of natural hazards and environmental changes. …”
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Wood Chip Incorporation in Almond Orchard Planting Berms Increased Gravimetric Water Content, Soil CO2 Efflux, and Fine Root Length Density by Hana You, Paul Martinez, Mae Culumber, Brent Holtz, Astrid Volder

“…In woody plants, the most external (fine) lateral roots are critical in acquiring water and nutrients and are the part of the root system that is most responsive to changes in the soil environment. …”
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