Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting. …”
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NCHD handover in the acute mental health setting: a quality improvement initiative implementing an electronic handover tool by Karen O’Connor, Stelios Naxakis, Megan Wafer, Syeda Gardezi, Aamina Sadia, Rimsha Mujahid

“…This quality improvement (QI) initiative aimed to standardise handover practices using an electronic tool integrated with the ISBAR communication protocol.Objectives The project aimed to ensure accurate clinical information recording, improve patient care and safety, centralise handover material, enhance clinical transparency and accountability, and measure handover quality using the electronic tool.Methods Using a Plan-Do-Study-Act (PDSA) model, the initiative began with a critical incident in July 2020, prompting the creation and piloting of an electronic ‘handover tool’ aligned with ISBAR. …”
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Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease. Although IL-33 expression can be altered upon NF-Kappa B activation, here we examine regulation by Oncostatin M, a gp130 cytokine family member, in mouse lung tissue. …”
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Vaccine-induced reduction of COVID-19 clusters in school settings in Japan during the epidemic wave caused by B.1.1.529 (Omicron) BA.2, 2022 by Yuta Okada, Hiroshi Nishiura

“…Clusters of COVID-19 in high-risk settings, such as schools, have been deemed a critical driving force of the major epidemic waves at the societal level. …”
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Quantitative and qualitative analysis of metallic ion release of orthodontic brackets in three different pH conditions - An invitro study by Pradeep DA, Saraa Angel L, Prabhat Kumar Chaudhari, Subhash C. Yadav, Ritu Duggal

“…Background: Fluoridated mouth rinses improve anti-cariogenic environment but decrease oral pH below critical value, affecting orthodontic bracket surface topography and causing corrosive changes over prolonged use. …”
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Agrolandscapes and their role in ensuring environmental safety by Larysa Piskunova, Tetiana Zubok, Alla Klepko, Kateryna Кarabach, Alina Kudryavytska

“…In particular, forest and forest-steppe agrolandscapes have proven to be the most effective in conserving species, which is critical for maintaining ecological balance. However, steppe and dry steppe landscapes require urgent and comprehensive measures to improve the state of biodiversity, as their ecological sustainability is under threat. …”
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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing by Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti

“…In our study, we experimented with different types and systematically investigated the variation of the critical micelle concentration (CMC) of poloxamers at 25 and 37 °C in different media. …”
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Low-budget equipment facilitating skid coefficient extraction for traffic accident analysis by Vinicius Lima, Umit Karabiyik, Felipe Kennedy, Igor Mello, Jorge Farias, Manoel Martins

“…Traffic accident reconstructionists play a vital role in providing reliable analyses to justice authorities by examining evidence at accident scenes. Skid marks, a critical form of evidence, are often used to calculate a vehicle's speed. …”
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Extreme Heating of Minor Ions in Imbalanced Solar-wind Turbulence by Michael F. Zhang, Matthew W. Kunz, Jonathan Squire, Kristopher G. Klein

“…The former results in characteristically arced ion velocity distribution functions, whose non-bi-Maxwellian features are shown by linear ALPS calculations to be critical to the heating process. Additional features include a steep transition-range electromagnetic spectrum, proton-cyclotron waves propagating in the direction of the imbalance, significantly enhanced proton-to-electron heating ratios, ion temperatures that are considerably more perpendicular with respect to magnetic field, and extreme heating of heavier species in a manner consistent with mass scalings inferred from spacecraft measurements. …”
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Understanding transmission pathways and integrated digital surveillance potential of antimicrobial resistance in Ethiopia in a One Health approach: a mixed-method study protocol by Muhammad Asaduzzaman, Christoph Gradmann, Andrea Sylvia Winkler, Zeleke Mekonnen, Ernst Kristian Rodland

“…Introduction Antimicrobial resistance (AMR) has a critical global impact, mostly affecting low- and middle-income countries. …”
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Influence of Infill Wall Configuration on Failure Modes of RC Frames by Xiaojie Zhou, Xiaoyuan Kou, Quanmin Peng, Jintao Cui

“…Based on the analysis results, a value of 2.0 is suggested for the critical shear bearing capacity ratio of the frame column to the infill wall. …”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Collectively, our combined analysis reveals a critical role of miR-34a/OAZ2 cascade in conferring a proper cellular response to CCa chemotherapy.…”
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The Content-Validated Geometry Lessons in Islam Observed Brain-based Learning by Sherma O. Sappari, Florante P. Ibarra, Amirul Mukminin, Kasinyo Harto, Lenny Marzulina, Herri Mulyono, Asmendri Asmendri

“…The infusion of religious values and appreciation of creation informs one’s understanding of the emotions and their importance for learning which are therefore critical to brain-based learning principles.   …”
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Toward Integrating ChatGPT Into Satellite Image Annotation Workflows: A Comparison of Label Quality and Costs of Human and Automated Annotators by Jacob Beck, Lukas Malte Kemeter, Konrad Durrbeck, Mohamed Hesham Ibrahim Abdalla, Frauke Kreuter

“…High-quality annotations are a critical success factor for machine learning (ML) applications. …”
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Exploring Early Learning Challenges in Children Utilizing Statistical and Explainable Machine Learning by Mithila Akter Mim, M. R. Khatun, Muhammad Minoar Hossain, Wahidur Rahman, Arslan Munir

“…To mitigate future educational challenges, the early childhood period is critical for cognitive development, so understanding the factors influencing child learning abilities is essential. …”
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A Stochastic Programming Approach for Scheduling Extra Metro Trains to Serve Passengers from Uncertain Delayed High-Speed Railway Trains by Sihui Long, Lingyun Meng, Xiaojie Luan, Alessio Trivella, Jianrui Miao, Francesco Corman

“…Hub stations connecting metro and high-speed railway (HSR) networks are particularly critical in this system. When HSR trains are delayed due to a disruption on the HSR network, passengers of these trains arriving at the hub station at night may fail to get their last metro connection. …”
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Excitation and Propagation of Longitudinal L (0, 2) Mode Ultrasonic Guided Waves for the Detection of Damages in Hexagonal Pipes: Numerical and Experimental Studies by Xiang Wan, Meiru Liu, Xuhui Zhang, Hongwei Fan, Qinghua Mao, Ming Dong, Xing Wang, Hongwei Ma

“…It has functioned as an essential and critical part of a drill stem in a high-torque drill machine used in various resource exploitation fields. …”
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Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma by Farshid Fathi, Behnam Sanei, Mazdak Ganjalikhani Hakemi, Reza F. Saidi, Abbas Rezaei

“…Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration.…”
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Analysis of Underwater Topographic Survey of Stilling Basin Based on Unmanned Survey System by Hui Xie, Haoran Wang, Yayi Yang, Yongcan Chen, Jun Yang, Shuang Wang, Zhaowei Liu

“…For the bottom outlet stilling basin of Tingzikou, there is large sediment within a range of 20 m∼40 m from the bottom sill and the maximum height of it reaches 2.04 m, while there is no obvious sediment or structural abnormality in the remaining region of basin. The critical sedimentation height can effectively judge the safety grade of the sedimentation height in stilling basin and provide a reliable support for assessing the overall safety of stilling basin. …”
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Estimation of Global Cardiovascular Risk in Hypertensive Patients from the University of Medical Sciences of Cienfuegos by Lucía Baños Leyva, Milagros Lisset León Regal, Luis Alberto Mass Sosa, Jacqueline Zamora Galindo, José Andy Hernández Quintana, Judeny Colls Cañizares

“…<br /><strong>Results:</strong> the female gender, the age group of 50-69 years, non-diabetics and non-smokers, with normal cholesterol and prehypertensive predominated. 93.3 % presented low overall cardiovascular risk and 6.7 % moderate to critical. Non-diabetic patients with normal systolic blood pressure presented a significant association with low cardiovascular risk. …”
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