Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus by Weiwei Ma, Chenyang Ren, Lin Shi, Bo Meng, Yali Feng, Ying Zhang

“…We also found that the HA-T137I substitution was critical for α2,6-linked sialic acid binding preference and HA activation and stability of H9N2 virus. …”
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Depositional environment of shallow-marine arenites in the Northern Apennines (Italy) affects aquifer performance: an interpretive key to groundwater management in a climate change... by Maria Filippini, Alessandro Amorosi, Enrico Dinelli, Stefano Segadelli, Laura Landi, Tommaso Casati, Alessandro Gargini

“…New Hydrological Insights for the Region: this study emphasizes the critical role of depositional environments in shaping the aquifer characteristics of the Pantano Formation. …”
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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release by Shengnan Zhao, Zizhen Gong, Xixi Du, Chunyan Tian, Lingyu Wang, Jiefei Zhou, Congfeng Xu, Yingwei Chen, Wei Cai, Jin Wu

“…Therefore, our findings suggest that S1PR2/ERK1/2/cathepsin B signaling plays a critical role in triggering inflammasome activation by DCA and S1PR2 may represent a new potential therapeutic target for the management of intestinal inflammation in individuals on a high-fat diet.…”
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Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage by Hongya Zhang, Xiaohui Li, Jing Bai, Cong Zhang

“…Background NOP2/Sun RNA methyltransferase 5 (NSUN5) is an RNA methyltransferase that has a broad distribution and plays critical roles in various biological processes. However, our knowledge of the biological functions of NSUN5 in mammals is very limited. …”
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Challenges in safe environmental applications of biochar: identifying risks and unintended consequence by Mingying Dong, Mengyuan Jiang, Lizhi He, Zirun Zhang, Williamson Gustave, Meththika Vithanage, Nabeel Khan Niazi, Bo Chen, Xiaokai Zhang, Hailong Wang, Feng He

“…While most research has focused on the benefits of biochar application in soil enhancement, water quality improvement, and climate change mitigation, the potential risks associated with its use have often been overlooked. This oversight is critical, as the environmental fate of biochar is contingent upon understanding these risks. …”
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Research on Cold-Energy Loss of Long-Distance Sleeve-Type Insulated Pipe for High-Temperature Deep Mines by Lijuan Zhang, Wenlong Wang, Fengtian Yue, Jingsheng Wei, Tao Gao, Yangjie Wang, Yang Zhou

“…As mining operations extend to greater depths, they encounter critical challenges, including increased distances and substantial energy losses. …”
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Network Digital Twin Toward Networking, Telecommunications, and Traffic Engineering: A Survey by Reza Poorzare, Dimitris N. Kanellopoulos, Varun Kumar Sharma, Poulami Dalapati, Oliver P. Waldhorst

“…Telecommunications, along with traffic engineering as one of its critical components, play a prominent role across various networking domains, including Internet service providers, data centers, cellular networks, intelligent transportation systems, and smart cities. …”
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The Implementation of Diverse Actuation System in ACPR1000 Nuclear Power Plants by Zhen-Ying Wang, Zhi-Yun Liu, Ting-Wei Ma, Chen Sun, Liu Liu, Yu Huang, Gang-Miao Guo

“…Insight into probabilistic safety assessment proves significant reductions of risks are contributed. The critical technical issues while implementing DAS, such as measures to ensure its diversity from RPMS, precautions for preventing from its spurious actuation, isolation and independency from RPMS, and its testability and maintainability, are deliberately settled to improve its engineering reliability and alleviate the impact on RPMS as far as possible. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Conclusions:</b> The OCA lips@Apt nanodrug demonstrated superior therapeutic efficacy with minimal off-target effects, offering a promising strategy to overcome critical barriers in liver fibrosis treatment. By precisely targeting the fibrotic ECM and modulating key pathological pathways, this TnC-guided liposomal delivery system provides a significant advancement in antifibrotic nanomedicine.…”
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Harnessing AI for sustainable higher education: ethical considerations, operational efficiency, and future directions by Sunawar Khan, Tehseen Mazhar, Tariq Shahzad, Muhammad Amir Khan, Ateeq Ur Rehman, Mamoon M. Saeed, Habib Hamam

“…The prospects and difficulties of AI in higher education are critically examined, including its potential to change traditional educational roles, improve academic performance, and maintain institutional profitability. …”
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Possible Superconductivity Transition in Nitrogen‐Doped Lutetium Hydride Observed at Megabar Pressure by Xingbin Zhao, Yu Huang, Shuailing Ma, Hao Song, Yanwei Cao, Hao Jiang, Yanping Huang, Tian Cui

“…Resistivity measurements in the Fm3¯m‐LuH3±xNy phase under varying magnetic fields exhibited characteristics consistent with superconductivity, with an upper critical field μ0Hc2(0) of 3.3 T measured at 163 GPa. …”
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A systematic review of Aspilia africana (Pers.) C.D. adams traditional medicinal uses, phytoconstituents, bioactivities, and toxicities by Gang, Roggers, Okello, Denis, Yeongjun, Ban, Kang, Youngmin

“…This study aimed to sys-tematically and critically compile data on the traditional medicinal uses, phytochemistry, bioactivities, botanical descriptions, and toxicities of A. africana. …”
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Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

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Editorial by Lindsay B. Flynn

“…It is too soon to tell how Covid-19 will affect housing access and affordability, but it is already clear that younger generations are experiencing a second “once-in-alifetime” crisis in their critical early adult years. The first, a global financial crisis, was triggered by the 2008 US housing market crash. …”
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Kontribusi Mazhab Teologis Mu'tazilah Dalam Perkembangan Sastra Arab Era Aabbasiyah Studi Analisis Kritis Historis by Zulhelmi Zulhelmi, Hajjah Rafidah binti Haji Abdullah, Shuhaida Hanim binti Mohamad Suhane, Ashwaq Ismail S Batubara, Ashwaq Ismail S Batubara, Delami

“…The theoretical framework employed is historical criticism theory, as the study's object involves historical facts of the Islamic golden age. …”
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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…The methodology underscores the critical implications of these findings and calls for urgent international intervention and accountability to protect education in conflict zones. …”
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Osiąganie kompromisu potrzeb człowieka i przyrody by Karol Lewandowski

“…The attention of researchers engaged in human activities in the natural environment was focused on criticizing of destruction and diverse propositions to stop this destruction, mainly by protectoral actions. …”
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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies by Bu-Fu Tang, Wang-Ting Xu, Shi-Ji Fang, Jin-Yu Zhu, Rong-Fang Qiu, Lin Shen, Yang Yang, Qiao-You Weng, Ya-Jie Wang, Jia-Yi Ding, Xiao-Jie Zhang, Wei-Qian Chen, Li-Yun Zheng, Jing-Jing Song, Biao Chen, Zhong-Wei Zhao, Min-Jiang Chen, Jian-Song Ji

“…This study aimed to identify the critical targets for regulating the efficacy of RFA. …”
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Fálétí’s Philosophical Sensibility by Adeshina Afolayan

“…Philosophy and literature, equally, offer critical evaluation of existing and possible forms of political arrangements, beliefs and practices. …”
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