Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…Sepsis-associated acute kidney injury (S-AKI) is a prevalent and life-threatening complication in hospitalized and critically ill patients. Recent researches indicates that immunoproteasome, especially proteasome 20S subunit beta 8 (PSMB8), is highly associated with various kidney diseases. …”
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Unraveling Community Potential Interactions by Environmental DNA in the Hong Kong Coastal Waters by Sangwook Scott Lee, Zhimeng Xu, Yingdong Li, Xiaodong Zhang, Jinping Cheng, Hongbin Liu

“…Our findings highlight the versatility of eDNA metabarcoding for studying potential species interactions, providing critical insights into ecosystem structure and stability, and offering suggestions for marine biodiversity conservation.…”
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Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. …”
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Digitalisation to zero-waste: the interplay of open eco-innovation and the circular economy in agricultural enterprises by Wutthiya Aekthanate Srisathan, Wongsatorn Worrakittikul, Kanokon Rattanapon, Thippayarat Hongto, Apichai Phrommasakha Na Sakhonnakon, Phaninee Naruetharadhol

“…The findings highlight the critical role of innovative digital practices in promoting sustainable ecosystems and addressing the urgent need for near-zero-waste strategies in agriculture. …”
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Proximate values and elemental analysis in wheat and soybean using inductively coupled plasma mass spectrometry by G. Kowmudi, V. Rashmi, K. Anoop, N. Krishnaveni, S. Naveen

“…BACKGROUND AND OBJECTIVES: Determining food composition and bioactivity is critical to both theoretical and applied research in food science and technology. …”
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Rating pome fruit quality traits using deep learning and image processing by Nhan H. Nguyen, Joseph Michaud, Rene Mogollon, Huiting Zhang, Heidi Hargarten, Rachel Leisso, Carolina A. Torres, Loren Honaas, Stephen Ficklin

“…Moreover, while these visual assessments are critical empirical data, they are often coarse‐grained and lack consistent objective criteria. …”
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Remote sensing-based winter wheat yield estimation integrating machine learning and crop growth multi-scenario simulations by Xin Du, Jiong Zhu, Jingyuan Xu, Qiangzi Li, Zui Tao, Yuan Zhang, Hongyan Wang, Haoxuan Hu

“…Accurate and timely winter wheat yield prediction is critical for effective agricultural management and food security. …”
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Does forest loss and fragmentation reduce woodpecker-associated ecosystem functions? by Kazuma Yasuda, Daiki Kato, Shoji Naoe, Tatsuya Amano, Tetsuro Yoshikawa, Kahoko Tochigi, Shinsuke Koike

“…Woodpeckers inhabiting large trees are particularly susceptible to forest loss and fragmentation. They play a critical role in the ecosystem, as they not only create tree cavities, but might also contribute to the number of tree falls. …”
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PMAIP1-mediated glucose metabolism and its impact on the tumor microenvironment in breast cancer: Integration of multi-omics analysis and experimental validation by Yidong Zhang, Hang Xu, Xuedan Han, Qiyi Yu, Lufeng Zheng, Hua Xiao

“…The model was used to classify clinical subtypes of breast cancer, and PMAIP1 was identified as a potential critical gene related to glucose metabolism in breast cancer. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. …”
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Impact of heat stress on growth and physiological parameters of soybean varieties at the seedling stage by Bashir Hassan, Samanhudi, Parjanto, Setyawati Andriyana, Komariah, Senge Masateru, Rahayu Muji, Salma Fathin Tilmiidzah

“…While all varieties showed optimal growth at 25°C, increasing temperatures from 25 to 30°C led to an increase in growth. A critical threshold was observed between 35 and 40°C, where most varieties experienced a sharp performance decline. …”
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Evaluation of the Influence of Sensor Geometry and Physical Parameters on Impedance-Based Structural Health Monitoring by L.V. Palomino, K.M. Tsuruta, J.R.V. Mour Jr, D.A. Radea, V. Steffen Jr., D.J. Inman

“…The environmental influences become more critical under certain circumstances, especially in aerospace applications, in which extreme conditions are frequently encountered. …”
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Development and Characterization of Lyophilized Chondroitin Sulfate-Loaded Solid Lipid Nanoparticles: Encapsulation Efficiency and Stability by Marta E. Bustos Araya, Anna Nardi Ricart, Ana C. Calpena Campmany, Rafel Prohens, Montserrat Miñarro Carmona

“…Two formulations (SLN-1 and SLN-2) were produced and optimized by evaluating critical physicochemical properties such as particle size, zeta potential, encapsulation efficiency (EE%), and stability. …”
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Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer by Minhua Deng, Zhaohui Zhou, Jiawei Chen, Xiangdong Li, Zefu Liu, Jingwei Ye, Wensu Wei, Ning Wang, Yulu Peng, Xin Luo, Lijuan Jiang, Fangjian Zhou, Xianchong Zheng, Zhuowei Liu

“…Abstract Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. …”
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Nurture-U student mental health longitudinal survey: a study protocol by Kate E Saunders, Samuel R Chamberlain, Jemima Dooley, Edward R Watkins, Liz Forty, Sarah Rees, Anne C Duffy, Anthony Quinn, Ellen Marshall, Lucy Dorey, Kevin A Matlock, Alexandra Newbold, Lucy J Robinson

“…Introduction University life represents a critical period for young adults, providing opportunities for personal growth and development of coping skills but also posing significant mental health challenges. …”
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High‐Performance Pure Water‐Fed Anion Exchange Membrane Water Electrolysis with Patterned Membrane via Mechanical Stress and Hydration‐Mediated Patterning Technique by Yeonjae Lee, Sungjun Kim, Yoseph Shin, Yeram Shin, Seongmin Shin, Sanghyeok Lee, Minseop So, Tae‐Ho Kim, Sehkyu Park, Jang Yong Lee, Segeun Jang

“…Abstract Despite rapid advancements in anion exchange membrane water electrolysis (AEMWE) technology, achieving pure water‐fed AEMWE remains critical for system simplification and cost reduction. …”
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Strengthening and toughening an ultra-high strength medium Mn steel by fibrous ferrite bridging mechanism by Chao Zhang, Qian Cheng, Bo Yang, Wuli Su, Xue Chen, Qingyuan Wang, Wenquan Cao, Chongxiang Huang

“…Achieving exceptional strength and ductility is a critical requirement for most materials. In this work, an ultra-strong medium Mn steel with hard martensite as the matrix and a large number of uniformly distributed long and coarse soft fibrous ferrites embedded within it had been designed. …”
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The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K by Adel Noubigh, Abdalazeem A. Omar, Manef Abderrabba

“…This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its solubility mechanisms for pharmaceutical formulation. …”
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Recombinant AAV batch profiling by nanopore sequencing elucidates product-related DNA impurities and vector genome length distribution by Florian Dunker-Seidler, Kathrin Breunig, Magdalena Haubner, Florian Sonntag, Markus Hörer, Rebecca C. Feiner

“…Our data highlight a high vector batch quality with low plasmid-derived and host cell DNA impurities of random origin, critical for mitigating associated safety risks. Finally, we compared nanopore data with orthogonal SMRT sequencing data and observed a higher base quality, but largely similar length and impurity profiles. …”
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TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques... by Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng

“…Thus, this study illustrated that TEAD1 played a critical role in promoting the trans‐differentiation of VSMCs into fibroblast‐like cells and subsequent extracellular matrix production through the Wnt4/β‐Catenin pathway. …”
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