Recovery of Bioactive Constituents from Olive Leaf Pruning Waste of Five Different Cultivars: A Comparison of Green Extraction Techniques to Maximize Health Benefits by Hamid Mushtaq, Simona Piccolella, Jose A. Mendiola, Lidia Montero, Elena Ibáñez, Severina Pacifico

“…Sustainable agro-waste revaluation is critical to enhance the profitability and environmental footprint of the olive oil industry. …”
Get full text

Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Type I interferon (IFN-I) plays a critical role in the antitumor immune response. In our previous study, we showed that IFN-I-inducible 2′-5′ oligoadenylate synthetase-like 1 (OASL1) negatively regulated IFN-I production upon tumor challenge similar to that of viral infection. …”
Get full text

Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…In an effort to elucidate important mechanisms that may play a critical role in the progression to overt disease, we propose a mathematical model that takes into account the dynamics of functional and dysfunctional $\beta$-cells, regulatory T cells, and pathogenic T cells. …”
Get full text

Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury: A Report of Three Cases in Which Surgeries Were Performed at Different Timings by Yohei Kawatani, Hirotsugu Kurobe, Yoshitsugu Nakamura, Yuji Suda, Takaki Hori

“…Blunt thoracic aortic injury (BTAI) is a critical condition. Thoracic endovascular aortic repair (TEVAR) is considered a surgical treatment for BTAI. …”
Get full text

The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature by Silvia Ciraolo, Agnieszka Kulczycka-Rowicka, Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec

“…While several mechanisms have been proposed, further research is necessary to rule which are most critical. The benefits observed with SGLT2 inhibitors stress their potential as a cornerstone in HF management, regardless of a patient’s diabetes status.       …”
Get full text

Ensuring Africa’s Food Security by 2050: The Role of Population Growth, Climate-Resilient Strategies, and Putative Pathways to Resilience by Belay Simane, Thandi Kapwata, Natasha Naidoo, Guéladio Cissé, Caradee Y. Wright, Kiros Berhane

“…Climate change is a critical factor in Africa’s food systems, with an average temperature increase of approximately +0.3 °C per decade. …”
Get full text

The Impact of Reich’s Vegetotherapy on Emotional Regulation and Postural Balance in Military Personnel: A Non-Pharmacological Approach to Combat Stress by Sana Khadhrani, Imed Touhemi, Amri Hammami, Chiraz Goumni, Jihen Khalfoun, Mohanad Omar, Rebai Haithem, Abderraouf Ben Abderrahman

“…This study examines the effectiveness of Reich’s vegetotherapy (VGT), an alternative non-pharmacological intervention, in improving these critical areas among military personnel. A total of 29 soldiers, with an average age of 30, were randomly assigned to either an experimental group (EG; 15 soldiers) or a control group (CG; 14 soldiers). …”
Get full text

Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Lear... by Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen

“…These findings supported the antidepressant efficacy of repeated routine low dose of Yueju in a long-term depression model and the critical role of CREB and NMDA signaling.…”
Get full text

Advances in Biomedical Missing Data Imputation: A Survey by Miriam Barrabes, Maria Perera, Victor Novelle Moriano, Xavier Giro-I-Nieto, Daniel Mas Montserrat, Alexander G. Ioannidis

“…To aid practitioners in method selection, we offer practical recommendations based on critical factors such as dataset size, data type, and missingness rate. …”
Get full text

Temporal variability of dissolved inorganic nitrogen and key environmental drivers in a dam-induced subtropical urban lake by Peng Tang, Boyu Ren, Tianyang Li, Qiwen Xu, Baoxiang Yang, Shunyao Zhu, Binghui He

“…The dissolved inorganic nitrogen (DIN) is a critical indicator of the organism growth and ecological balance within aquatic systems. …”
Get full text

The Significant Effects of Threshold Selection for Advancing Nitrogen Use Efficiency in Whole Genome of Bread Wheat by Mohammad Bahman Sadeqi, Agim Ballvora, Said Dadshani, Md. Nurealam Siddiqui, Mohammad Kamruzzaman, Ahossi Patrice Koua, Jens Léon

“…Therefore, the threshold plays a critical role to identify reliable and significant associations in wide genome, while the proportion of false positive results is relatively low. …”
Get full text

Nonlinear responses of ecosystem carbon fluxes to precipitation change in a semiarid grassland by Hua Chai, Hua Chai, Jianying Ma, Jinwei Zhang, Junqin Li, Bo Meng, Chengliang Wang, Duofeng Pan, Jie Li, Wei Sun, Xuhui Zhou

“…Carbon (C) fluxes in semiarid grasslands subject to precipitation variability play a critical role in the terrestrial C cycle. However, how ecosystem C fluxes respond to variability in precipitation (both decreases and increases precipitation along a gradient) remains unclear. …”
Get full text

GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Nonresolving inflammation is one of the consistent features of the tumor microenvironment in the intestine and plays a critical role in the initiation and development of colon cancer. …”
Get full text

A Scoping Review of Educational and Training Interventions on Parkinson’s Disease for Staff in Care Home Settings by Stacey Finlay, Tara Anderson, Elizabeth Henderson, Christine Brown Wilson, Patrick Stark, Gillian Carter, Matthew Rodger, Mihalis Doumas, Emma O’Shea, Laura Creighton, Stephanie Craig, Sophie Crooks, Arnelle Gillis, Gary Mitchell

“…However, these studies also highlighted a critical need for more specialized PD training among care home staff. …”
Get full text

Behind the scenes with genomics researchers by Renata Mont’Alverne, Lori Bradford, Cheryl Buckmaster, Graham Strickert, Jason MacLean, Diane Dupont

“…This study underscores scientists’ self-awareness within the genomics discipline, acknowledging how their beliefs and biases shape research outcomes. It illuminates critical reflections essential for navigating societal and scientific landscapes in genomics research.…”
Get full text

Hydrologic responses of watershed assessment to land cover and climate change using soil and water assessment tool model by R.C.C. Puno, G.R. Puno, B.A.M. Talisay

“…The model provided potential implications of land conversions and climate change adversely affecting hydrologic processes of critical watersheds. Climate change projections with a 13% decrease in rainfall directly influenced the decrease in hydrologic processes. …”
Get full text

Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells by Callinice D. Capo-chichi, Jennifer L. Smedberg, Malgorzata Rula, Emmanuelle Nicolas, Anthony T. Yeung, Richard F. Adamo, Andrey Frolov, Andrew K. Godwin, Xiang-Xi Xu

“…Dab2, Laminin, GATA4, GATA5, and GATA6 are expressed in embryonic primitive endoderm and play critical roles in its lineage commitment. Results. …”
Get full text

Liver transcriptomics-metabolomics integration reveals biological pathways associated with fetal programming in beef cattle by Guilherme Henrique Gebim Polizel, Simara Larissa Fanalli, Wellison J. S. Diniz, Aline Silva Mello Cesar, Nara Regina Brandão Cônsolo, Heidge Fukumasu, Angela Cánovas, Arícia Christofaro Fernandes, Barbara Carolina Teixeira Prati, Édison Furlan, Gabriela do Vale Pombo, Miguel Henrique de Almeida Santana

“…This study highlights the significant impact of prenatal nutrition on the liver tissue of Nelore bulls, shedding light on critical metabolic pathways and hub components related to energy and protein metabolism, as well as immune system and epigenetics.…”
Get full text

A thermodynamic description of metastable c-TiAlZrN coatings with triple spinodally decomposed domains by Zhou J., Zhang L., Chen L., Du Y., Liu Z.K.

“…A critical thermodynamic assessment of the metastable c-TiAlZrN coatings, which are reported to spinodally decompose into triple domains, i.e., c-TiN, c-AlN, and c-ZrN, was performed via the CALculation of PHAse Diagram (CALPHAD) technique based on the limited experimental data as well as the first-principles computed free energies. …”
Get full text

Soil microbiome interventions for carbon sequestration and climate mitigation by Gwyn A. Beattie, Anna Edlund, Nwadiuto Esiobu, Jack Gilbert, Mette Haubjerg Nicolaisen, Janet K. Jansson, Paul Jensen, Marco Keiluweit, Jay T. Lennon, Jennifer Martiny, Vanessa R. Minnis, Dianne Newman, Raquel Peixoto, Christopher Schadt, Jan Roelof van der Meer

“…Among the many knowledge gaps in this field, crucial gaps include the processes influencing the transformation of plant-derived soil carbon inputs into SOM and the identity of the microbes and microbial activities impacting this transformation. As a critical step forward, we encourage broadening the current widespread screening of potentially beneficial soil microorganisms to encompass functions relevant to stimulating soil carbon stocks. …”
Get full text