HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Abstract Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, thus representing promising targets for immunotherapy. …”
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The Analytical Approach to Evaluate the Load-Displacement Relationship of Rock Bolts by Jianhang Chen, Shengli Yang, Hongbao Zhao, Junwen Zhang, Fulian He, Shuaifeng Yin

“…However, once Young’s modulus of the confining medium was beyond a critical limit, it had marginal effect on the peak load of rock bolts. …”
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A Comprehensive 10-Year Nationwide Pharmacovigilance Surveillance on Antibacterial Agents in Korea: Data Mining for Signal Detection of Trends and Seriousness of Adverse Events by Seon Hu Mo, Soo Hyeon Lee, Chang-Young Choi, Yongjun Sunwoo, Sooyoung Shin, Yeo Jin Choi

“…However, further studies are imperative to determine the causality of antibacterial-induced ADEs in critically ill patients.…”
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Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India by Nabeela Usmani, Mukhtar Ahmad, Saba Khan, Mohammad Mustufa Khan, Haseeb Ahsan, Sadaf Parveen, Roshan Alam

“…Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. …”
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Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics by Sheng Yang, Yiling Ge, Tianyi Zhang, Lihong Yin, Yuepu Pu, Zaozao Chen, Geyu Liang

“…Overall, this study observed the multifaceted toxicological responses of PS-NPs to the respiratory system, emphasizing the critical involvement of ncRNAs in mediating PS-NP-induce transitional cells, which was crucial for elucidating the pathophysiology of nanoplastic-induced lung injury and developing targeted therapeutic strategies.…”
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Study on the Rock Size Effect of Quasistatic and Dynamic Compression Characteristics by Jun Zhou, Xiangrui Meng, Chongyan Liu, Zhixi Liu, Wensong Xu, Xiang Cheng

“…By improving the Weibull distribution formula and considering variation in strain rate caused by the size of the specimen, the dynamic compressive strength of rocks of different volumes is calculated by introducing the critical strain rate and related parameters, and the results are similar to the experimental dynamic compressive strength obtained. …”
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Future Extreme Climate Events Threaten Alpine and Subalpine Woody Plants in China by Yongru Wu, Jian Shen, David C. Deane, Haibin Yu, Fangyuan Yu, Xuerong Wang, Zheng Cao, Rong Yu, Fuan Xiao, Tiejun Wang, Zhifeng Wu

“…We suggest inclusion of ECEs is critical when projecting changes in alpine and subalpine species distributions for effective conservation planning for climate change.…”
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Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study by Jun Wang, Pan Zhou, Xin Li, Li Zhou, Zhe Deng

“…Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with a 6% decrease in mortality risk (adjusted OR 0.94, 95% CI 0.93–0.95, p < 0.0001), while above it, each 10 × 10⁹/L increase was associated with a 1% increase in mortality risk (adjusted OR 1.01, 95% CI 1.00–1.01, p = 0.0153).ConclusionThis large-scale, multicenter retrospective study has made a significant contribution to understanding the association between platelet count and mortality in patients with sepsis in intensive care units. We identified a critical threshold of 176 × 109/L for platelet count and demonstrated a distinct U-shaped relationship with 30-day in-hospital mortality, providing valuable reference criteria for clinical risk stratification.…”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy. …”
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CADD based designing and biological evaluation of novel triazole based thiazolidinedione coumarin hybrids as antidiabetic agent by Anchal Sharma, Anmol Narang, Nitish Kumar, Rupali Rana, Megha, Pooja, Muskan Dhir, Harmandeep Kaur Gulati, Jyoti, Aanchal Khanna, Jatinder Vir Singh, Sukhraj Kaur, Preet Mohinder Singh Bedi

“…Compound I-1 was synthesized based on the insights gained from molecular docking and simulations, which helped predict interactions and identify critical structural features. Pharmacokinetic properties were evaluated through drug-likeness and ADMET studies. …”
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Flow stress-strain curves and dynamic recrystallization behavior of high carbon low alloy steels during hot deformation by D.Z. Li, X.M. Zhao, H.L. Zhang, J. Li

“…Based on the dislocation density theory, this paper established the stress-strain curve equation and analyzed in detail the critical stresses for nucleation and growth of DRX in relation to the stress-strain curve. …”
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Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology by Takamasa Mizoguchi, Ayumi Maki, Yuno Nakase, Mayu Okita, Yuina Minami, Misa Fukunaga, Motoyuki Itoh

“…Ischemic stroke (IS) is a pathological condition characterized by the cessation of blood flow due to factors such as thrombosis, inflicting severe damage to the cranial nervous system and resulting in numerous disabilities including memory impairments and hemiplegia. Despite the critical nature of this condition, therapeutic options remain limited, with a pressing challenge being the development of treatments aimed at restoring neurological function. …”
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CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment by Klaudia Bonowicz, Dominika Jerka, Klaudia Piekarska, Janet Olagbaju, Laura Stapleton, Munirat Shobowale, Andrzej Bartosiński, Magdalena Łapot, Yidong Bai, Maciej Gagat

“…Recent developments have extended the capabilities of CRISPR-Cas9 to include mitochondrial genome editing, a critical advancement for addressing mitochondrial dysfunctions often linked to cardiovascular disorders. …”
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Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta by Amira M. Gamal-Eldeen, Hassan Amer ‎, Cinderella A. ‎ Fahmy, Haytham ‎ Dahlawi, Basem H ‎ Elesawy, Nahla L. ‎ Faizo, Bassem M. ‎ Raafat

“…SCE exhibited a strong scavenging affinity towards critical radicals (hydroxyl and peroxyl). It induced lymphocyte growth and modulated the macrophage functions into an anti-inflammatory profile, via elevating macrophage proliferation and its binding affinity of fluorescein isothiocyanate-lipopolysaccharide (FITC-LPS) and inhibiting nitric oxide and tumor necrosis factor-α generation. …”
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The Relationship Between Gender and Women’s Tobacco Use: An Ecological Analysis with Country-level Data by Hanife Ece Erik, Tülin Çoban, Lütfiye Hilal Özcebe

“…MATERIAL AND METHODS: The study investigates correlations between the Gender Development Index (GDI), the Global Gender Gap Index (GGGI), and its sub-indicators—critical markers of gender equality—and tobacco prevalence and tobacco-related mortality. …”
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Microplastics in food products: Prevalence, artificial intelligence based detection, and potential health impacts on humans by M. Amin Mir, Muhammad Azhar Ali Khan, Bimal Krishna Banik, Syed M. Hasnain, Lina Alzayer, K. Andrews, Sani I. Abba

“…It also talks about how crucial it is to comprehend the origins and routes of contamination in order to lessen the impact of microplastics in the food supply chain. Critical future research directions are outlined including the creation of regulatory frameworks to restrict exposure to microplastics, standardized detection techniques, and longitudinal human health studies. …”
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PRMT1 Promotes the Self‐renewal of Leukemia Stem Cells by Regulating Protein Synthesis by Min Zhou, Yi Huang, Ping Xu, Shuyi Li, Chen Duan, Xiaoying Lin, Shilai Bao, Waiyi Zou, Jingxuan Pan, Chang Liu, Yanli Jin

“…This study verifies the critical role of protein arginine methyltransferase 1 (PRMT1) in the maintenance of CML LSCs. …”
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Work-Domain Goal Orientation: A Theoretical Framework for the Construct and Turkish Adaptation of a Work-Domain Goal Orientation Instrument by Aysun Gurol, Dilek Ilhan Findikoglu, Mehmet Gurol, Fuat Findikoglu, Mehmet Yesilkaya

“…This study brings a novel perspective to the relationship between higher education and work life by examining work-domain goal orientation as a critical factor in preparing students for professional environments. …”
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Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

“…This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins—namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. …”
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The role of the interleukin family in liver fibrosis by Zixin Zhang, Zixin Zhang, Jiahui Wang, Hui Li, Qun Niu, Qun Niu, Yujing Tao, Yujing Tao, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Haijian Dong, Haijian Dong

“…Liver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. …”
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