The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…The upregulation of small ubiquitin-like modifier (SUMO) is a prevalent posttranslational modification (PTM) in various cancers and plays a critical role in tumor development. The dysregulation of SUMOylation can protect cancer cells from stresses exerted by external or internal stimuli. …”
Get full text

Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics by You Hu, Jun Xu, Jian Lv, Yan Qin, Yongda Lu, Fan Cen, Hongbao Yang, Kai Chen, Suhua Xia

“…Gastric cancer is characterized by high heterogeneity, with its complex microenvironment and intercellular communications playing critical roles in disease progression and treatment responses. …”
Get full text

Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching by Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu

“…Innate immunity, particularly macrophages, is critical for intestinal homeostasis. Sulforaphane, a dietary isothiocyanate from cruciferous vegetables, has been reported to protect against intestinal inflammation. …”
Get full text

Advancing hydrological modeling through multivariate calibration of multi-layer soil moisture dynamics by Yan He, Huihui Mao, Chen Wang, Jinghao Hu, Sarawut Ninsawat, Xianfeng Song, Guifei Jing, Runkui Li, Mingyu Wang, Zheng Duan

“…Study region: The Meichuan Basin, China Study focus: Soil water processes are critical in hydrological modeling, yet most studies focus on surface moisture due to data limitations, which hampers accurate simulations of root zone soil moisture dynamics. …”
Get full text

Study on the Motion Patterns of Nested Test Cabin and Its Shock Response Spectrum Analysis by Wei Wu, Wei Luo, Xing Liu, Jia Cui, Pengyu Zhang

“…These oscillation wavelets occur when the critical acceleration of the test cabin reaches approximately 4700g. …”
Get full text

Thermosensitive injectable in situ forming hydrogel incorporating anti-oxidative stress and anti-inflammatory nanoparticles for vital pulp therapy of pulpitis by Lixin Zhang, Xianling Ning, Jingyi Cui, Yanqiang Zhao, Fei Xie, Ningxin Zhu, Dan Wang, Man Qin, Zhiqiang Lin, Yuanyuan Wang

“…Vital pulp therapy is critically important for the long-term preservation of teeth with pulpitis. …”
Get full text

Synthetic design and analysis on microwave dielectric properties of novel garnet-type Ca3MTiGe3O12 (M = Co, Ni) ceramics by Yuan Nie, Yanjun Liu, Ziqi Zhao, Wenjie Zhang, Fangyi Huang, Huanfu Zhou

“…The lattice energy and packing fraction are both critical factors that influence the Q×f value of CCTG ceramics. …”
Get full text

Performance Improvement in Pile Anchor System for Deep Foundation Excavation Using Electroosmotic Chemical Treatment by Lei Zhang, Bing-Hui Wang, Li-Yan Wang, Li-Ping Jing, Chen Fang, Zhen-Dong Shan

“…Finally, parametric analyses were performed to investigate effects of several parameters on anchoring force in terms of the ultimate pull-out capacity of the anchor, identifying critical parameters for the field study. Based on laboratory test results, field studies were carried out in the Yingkou city. …”
Get full text

Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma by Lin Wang, Xinyu Liu, Haoze Lv, Han Zhang, Rimei Lin, Shan Xu, Chaojing Zhang, Shilei Lou, Zhidong Qiu, Cong Sun, Ning Cui

“…miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. …”
Get full text

Learning to Boost the Performance of Stable Nonlinear Systems by Luca Furieri, Clara Lucia Galimberti, Giancarlo Ferrari-Trecate

“…The growing scale and complexity of safety-critical control systems underscore the need to evolve current control architectures aiming for the unparalleled performances achievable through state-of-the-art optimization and machine learning algorithms. …”
Get full text

A Review on Deep Learning for Quality of Life Assessment Through the Use of Wearable Data by Vasileios Skaramagkas, Ioannis Kyprakis, Georgia S. Karanasiou, Dimitris I. Fotiadis, Manolis Tsiknakis

“…Notably, wearable sensory devices have gained prominence, offering real-time data on vital signs and enabling remote healthcare monitoring. This review critically examines DL's role in QoL assessment through the use of wearable data, with particular emphasis on the subdomains of physical and psychological well-being. …”
Get full text

Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. by Chetna Singla, Dhananjay Tiwari, Himali Jha, Mohammad Mustufa Khan, Sadaf Parveen, Roshan Alam

“…COVID-19 survivors who are critically ill featured hyper inflammation and the associated biomarkers may be useful for risk stratification. …”
Get full text

Age and moisture affect the relationship between competition and tree growth by Xinyu Han, Lushuang Gao, Mingqian Liu, Yihong Zhu, Keda Cui, Xinyu Zhang, Xiuhai Zhao, Ruibo Zhang, Klaus von Gadow, Yiyu Tian, Kangchen Wang

“…While competition among trees is recognized as a critical factor influencing their growth, the precise mechanism underlying its impact remains unclear. …”
Get full text

Comparison between Hyperspectral Imaging and Chemical Analysis of Polyphenol Oxidase Activity on Fresh-Cut Apple Slices by Luna Shrestha, Boris Kulig, Roberto Moscetti, Riccardo Massantini, Elke Pawelzik, Oliver Hensel, Barbara Sturm

“…Determination of polyphenol oxidase activity (PPO) in apples is critical for controlling the quality of the final product (i.e., dried apples and juices). …”
Get full text

Microwave Ablation Combined with Flt3L Provokes Tumor‐Specific Memory CD8+ T Cells‐Mediated Antitumor Immunity in Response to PD‐1 Blockade by Meixiang Wang, Jing Sang, Fengkuo Xu, Shulong Wang, Peng Liu, Ji Ma, Zhengtao Chen, Qi Xie, Zhigang Wei, Xin Ye

“…The upregulation of ICOSL on migratory cDC1s was pivotal in initiating TTSM‐like cell‐mediated antitumor responses. Slc38a2 may be a critical gene responsible for the upregulation of ICOSL in Mig cDC1s following combined treatment. …”
Get full text

Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics by Zhang Suping, Liu Yuqing, Dong Jin, Jiao Min, Gu Yongchun, Chen Liling, Yuan Na, Wang Jianrong, Yang Dezhao, Meng Fanwen

“…These proteins are known to be involved in critical cellular processes such as mitochondrial energy metabolism, mTOR-related autophagy pathway, and innate immune response. …”
Get full text

Identification and interpretive ranking of factors affecting the improvement of agility in business process management by Sadegh Hasani Moghadam, Mohammad Mahdi Mohtadi, Hossein Bazargani, Ali Taheri, Mohsen Miri

“…Purpose: The main goal of this study is to present a novel model for managing organizational processes possessing the necessary agility in complex situations. One of the most critical requirements of such a model is using systems thinking and a soft operations research approach because the methods introduced in the background to achieve the agility of the process management generally include fragmentary optimization because of the one-dimensional view and the lack of a system view to identifying agility variables in process management.Methodology: In this study, an attempt was made to provide a comprehensive model using the interpretative paradigm's capabilities. …”
Get full text

The Recent Technologies to Curb the Second-Wave of COVID-19 Pandemic by M. Poongodi, Mohit Malviya, Mounir Hamdi, Hafiz Tayyab Rauf, Seifedine Kadry, Orawit Thinnukool

“…Different epidemics, specially Coronavirus, have caused critical misfortunes in various fields like monetary deprivation, survival conditions, thus diminishing the overall individual fulfillment. …”
Get full text

miR-142-3p Contributes to Early Cardiac Fate Decision of Embryonic Stem Cells by Zhong-Yan Chen, Fei Chen, Nan Cao, Zhi-Wen Zhou, Huang-Tian Yang

“…Our findings provide new knowledge for further understanding of roles and mechanisms of miRNAs as critical regulators of cardiomyocyte differentiation.…”
Get full text

IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass by Daniele Bianchi, Luca Topazio, Gabriele Gaziev, Valerio Iacovelli, Pierluigi Bove, Alessandro Mauriello, Enrico Finazzi Agrò

“…A multidisciplinary approach can be useful, although in clinical practice the selection of patients suspected of having IgG4-RKD is critical in the cases presenting with a renal mass that mimics malignancy.…”
Get full text