Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…The inverse correlation between NK activity and metastasis incidence supports a critical role for NK cells in human metastatic surveillance. …”
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Measurement of the temperature-dependent cross-plane thermal conductivity of the Li-ion battery pouch cell by Minjoo Kim, Dong-min Kim, Young-Beom Kim, Bong Jae Lee

“…This research provides a detailed framework for evaluating the cross-plane thermal conductivity of Li-ion batteries, offering critical insights into their thermal behavior at different temperatures and contributing to developing their improved thermal management strategies.…”
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Spatial mismatch and congruence in the taxonomic, functional, and phylogenetic diversities of fish assemblages in China's water diversion lakes by Zhice Liang, Rodolphe Elie Gozlan, Chenyi Kuang, Jiashou Liu, Chuanbo Guo

“…The interplay of evolutionary, ecological, and anthropogenic processes is critical in shaping species distributions and biodiversity patterns. …”
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Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients by Federico Melograna, Padhmanand Sudhakar, Behnam Yousefi, Behnam Yousefi, Clara Caenepeel, Gwen Falony, Gwen Falony, Gwen Falony, Sara Vieira-Silva, Sara Vieira-Silva, Sara Vieira-Silva, Sreenikhitha Krishnamoorthy, David Fardo, Bram Verstockt, Bram Verstockt, Jeroen Raes, Jeroen Raes, Severine Vermeire, Severine Vermeire, Kristel Van Steen

“…Utilising network topological metrics, we further validated these findings, demonstrating that critical microbial features identified through ISNs can differentiate responders from non-responders with respect to various therapeutic outcomes. …”
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INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. …”
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The Molecular Diagnosis Protocols of New Coronavirus (COVID-19); Specificity and Sensitivity an Overview by Abdullah Ahmed Hama, Othman Abdulrahman Mohammed, Fatima Mahmud Ali, Osama Hamid Shareef, Sardar Muhammad Wli, Sabiha Sharif, Syamand Ahmed Qadir

“…Early diagnosis of the etiological agents is critical for appropriate management, controlling plan, protection, and treatment. …”
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Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Abstract Tumor‐associated macrophages (TAMs) play critical roles in reprogramming other immune cells and orchestrating antitumor immunity. …”
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Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children by Yuu-Hueih Hsu, Chih-Yin Wu, Hui-Ling Lee, Ru-Lan Hsieh, Ya-Li Huang, Horng-Sheng Shiue, Ying-Chin Lin, Mei-Chieh Chen, Yu-Mei Hsueh

“…Abstract DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. …”
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Enhancing Mars Gravity Field Solutions with China’s Tianwen-1 Tracking Data by Shangbiao Sun, Jianguo Yan, Shanhong Liu, Chongyang Wang, Denggao Qiu, Jean-Pierre Barriot

“…These findings highlight the scientific value of TW1 tracking data in advancing Mars’s gravity field modeling and provide critical insights for future deep-space missions.…”
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One-pot green synthesis of BSA-capped O-CQDs as an effective fluorescent sensing platform for sensitive and selective detection of promethazine drug by S. Viji, A. Dinesh, K. Radhakrishnan, L. Srimathi Priya, C. Sivasankari, Madhappan Santhamoorthy, Manikandan Ayyar, V. Mohanavel, Mohamed Hashem, Hassan Fouad, G. Ramachandran, S. Santhoshkumar

“…The primary advantages of this technique include simplified sample preparation together with economic advantages which make it a critical instrument for public health monitoring as well as cutting-edge pharmaceutical research. …”
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Investigation study of face mask consumption in Malaysia and its impact on environment by Low Chung-Yu, Bee Soo-Tueen, Law Yung-Siang, Lee Tin-Sin, Bee Soo-Ling

“…Although face masks might protect us against the COVID-19 virus, inappropriate disposal of used face mask can have a negative impact on the environment. As a result, it is critical to analyse the consumption of face masks and its Life Cycle Assessment to explore the environmental consequences for long-term development. …”
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Rainy and Dry Seasons Are Relevant Factors Affecting Chemical and Antioxidant Properties of Meliponini Honey by Flavia C. Lavinas, Brendo A. Gomes, Marcos V. T. Silva, Raissa Lima, Suzana G. Leitão, Mirian R. L. Moura, Rosineide C. Simas, Renata F. Barbosa, Fabricio O. Silva, Carla S. Carneiro, Igor A. Rodrigues

“…Multivariate analysis identified <i>m</i>/<i>z</i> ions (VIP scores > 2.5), rather than physicochemical or antioxidant capacity parameters, as critical for seasonal discrimination. The antioxidant activity, assessed by oxidative hemolysis prevention, was robust across the seasons, with <i>M. mondury</i> honey (2 mg·mL⁻¹) from the rainy season outperforming ascorbic acid. …”
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A model-based factorization method for scRNA data unveils bifurcating transcriptional modules underlying cell fate determination by Jun Ren, Ying Zhou, Yudi Hu, Jing Yang, Hongkun Fang, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Qiyuan Li

“…In real datasets, MGPfactXMBD recovered the critical pathways and cell types in microglia development with experimentally valid regulons and markers. …”
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Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil by Mohamed Bouhrim, Nour Elhouda Daoudi, Hayat Ouassou, Amina Benoutman, El Hassania Loukili, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham

“…Hence, this plant could be a significant source of medically important critical compounds.…”
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Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis by Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia

“…Notably, under niraparib exposure, a critical fatty acid transporter CD36 was dramatically upregulated in tumors, facilitating excessive uptake of fatty acids. …”
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Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways by Shijia Tang, Yue Yan, Xiaoli Lu, Peng Wang, Xueqin Xu, Ke Hu, Sen Yan, Zhaobin Guo, Xiao Han, Feimin Zhang, Ning Gu

“…Abstract Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical factors to promote the osteogenic differentiation of stem cells has been established as a new strategy for developing bone tissue engineering scaffolds. …”
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Genotyping Genebank Collections: Strategic Approaches and Considerations for Optimal Collection Management by Noelle L. Anglin, Peter Wenzl, Vania Azevedo, Charlotte Lusty, David Ellis, Dongying Gao

“…The maintenance of plant germplasm and its genetic diversity is critical to preserving and making it available for food security, so this invaluable diversity is not permanently lost due to population growth and development, climate change, or changing needs from the growers and/or the marketplace. …”
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Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses by Chukwudi A. Ofodile, Ikemefuna C. Uzochukwu, Fortunatus C. Ezebuo, InnocentMary Ejiofor, Mercy Adebola, Innocent Okpoli, Beatrice Cubitt, Haydar Witwit, Chetachi B. Okwuanaso, Ngozi Onyemelukwe, Juan Carlos de la Torre

“…We used in silico docking approaches to investigate the binding affinities of 2015 existing drugs to LASV proteins known to play critical roles in the formation and activity of the virus ribonucleoprotein complex (vRNP) responsible for directing replication and transcription of the viral genome. …”
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An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy by Fumio Takano, Kaori Ueda, Takuji Kurimoto, Mina Arai, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

“…The secondary outcomes included changes in visual field; LogMAR; critical flicker frequency; and inner retinal thickness. …”
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The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…Survival analysis was conducted to screen and validate critical genes. In this study, 775 downregulated DEGs were identified. …”
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