Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…This information is critical for defining the transport mechanism and for further structure-activity relationship studies. …”
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Gastrointestinal System Involvement in Pediatric Patients with Acute SARS-CoV-2 Infection by Ozlem KALAYCIK SENGUL, Burcin BEKEN, Zehra OZTURK, Seyma OZPINAR, Gizem OZKAN, Gizem GUNGOR

“…Moreover, 17 (21.5%) and 4 (7.8%) patients from the RS group had severe-critical respiratory symptoms, in the RS+GIS group had severe-critical respiratory symptoms (p=0.039). …”
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Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review by Wai Sinn Soh, Grace L. Burns, Tharindu Senanayake, Raquel Cameron, Kerith Duncanson, Guy D. Eslick, Sharmila S. Prasad, Stephen R. Smith, Simon Keely

“…PRISMA guidelines were followed. Critical appraisal was undertaken using the Joanna Briggs Institute Critical Appraisal tools for quasi-experimental studies and randomised controlled trials. …”
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DGL-STFA: Predicting lithium-ion battery health with dynamic graph learning and spatial–temporal fusion attention by Zheng Chen, Quan Qian

“…Accurately predicting the State of Health (SOH) of lithium-ion batteries is a critical challenge to ensure their reliability and safety in energy storage systems, such as electric vehicles and renewable energy grids. …”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. …”
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From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…The membrane’s efficacy was tested by creating a critical bicortical and bilateral osteoperiosteal defect in rabbit mandibles. …”
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Investigating the Effectiveness of Serious Games in Educating Neonatal Resuscitation: A Systematic Review by Parisa Farshid, Kayvan Mirnia, Peyman Rezaei-Hachesu, Elham Maserat, Taha Samad-Soltani

“…Background: Neonatal resuscitation is a critical skill that requires regular training and practice; however, traditional training methods are often limited by accessibility, cost and engagement. …”
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Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation by Jingjing Zhang, Lei Song, Zhongwei Ma, Lina Sun, Xiaoqing Wang, Duanyan Liu, Feng Huang, Yulin Man

“…Additionally, an optimal critical pressure of 15.65 cmH2O was identified for predicting the rate of RRF decline. …”
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MGATAF: multi-channel graph attention network with adaptive fusion for cancer-drug response prediction by Dhekra Saeed, Huanlai Xing, Barakat AlBadani, Li Feng, Raeed Al-Sabri, Monir Abdullah, Amir Rehman

“…Abstract Background Drug response prediction is critical in precision medicine to determine the most effective and safe treatments for individual patients. …”
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Impact of landscape patterns on river water quality: Spatial-scale effects across an agricultural-urban interface by Kun Mei, Haonan Shi, Yupeng Wu, Randy A. Dahlgren, Xiaoliang Ji, Minmin Yang, Yueru Guan

“…The largest patch index of agricultural land (A_LPI) and water bodies (W_LPI) were identified as the most critical landscape indices influencing water quality at the dynamic sub-watershed scale, with threshold values for these indices established as A_LPI < 10 % and W_LPI > 1.5 %. …”
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Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research by Foteini Stefania Koumpa, Diamantis Xylas, Maciej Konopka, Dieter Galea, Kirill Veselkov, Anthony Antoniou, Akash Mehta, Reza Mirnezami

“…Early diagnosis and a deeper understanding of the biological mechanisms that regulate CPM are critical to refining patient selection for radical treatment, personalising therapeutic approaches, enhancing prognostication, and ultimately improving long-term survivorship. …”
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Cryptic transmission of a SARS-CoV-2 variant detected by wastewater surveillance in Panama by Melissa Gaitán, Yamitzel Zaldivar, Michelle Hernandez, Jessica Góndola, Oris Chavarría, Brechla Moreno, Danilo Franco, Rodrigo DeAntonio, Santiago Mirazo, Florencia Cancela, Maria Eugenia Barnett, Alexander A. Martinez, Juan Miguel Pascale, Sandra López-Vergès

“…The COVID-19 pandemic highlighted the critical role of viral genomic surveillance, prompting numerous countries to enhance their monitoring systems for acute respiratory infections (ARIs), especially influenza-like illnesses (ILIs). …”
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Efficient Beach Litter Monitoring: Accelerated Surveys of Pollution Hotspots—A North African Case Study by Emna Ben Slimane, Mirco Haseler, Lilia Ben Abdallah, Fadhel Mhiri, Abdallah Nassour, Gerald Schernewski

“…Marine litter is a critical environmental issue, with beach litter being its most visible indicator. …”
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Genetic status assessment and future development forecast for an isolated giant panda population by Jiabin Liu, Jiaojiao Yu, Wenlei Bi, Mingxia Fu, Xiang Yu, Rong Hou, Xinqiang Song, Rui Ma, Yanshan Zhou, Zusheng Li, Hong Yang, Wei Wu, Jiang Gu, Chong Huang, Long Zhang, Xiaodong Gu, Haijun Gu, Daode Yang, Dunwu Qi

“…The giant panda is a critical species for biodiversity conservation, yet the majority of its subpopulations are at high risk of extinction. …”
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Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions. …”
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The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion by Jing Yang, Zhunan Li, Aicong Li, Yayi Liu, Xinyan Zhang, Yong Zhang, Yuanpeng Gao

“…Overall, our findings revealed that bCoronin-1A had a critical impact on mycobacterial survival in macrophages by inhibiting calcium-mediated phagosome-lysosome fusion. …”
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Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era by Oscar A. Garcia Valencia, Charat Thongprayoon, Jing Miao, Jackrapong Bruminhent, Iasmina M. Craici, Wisit Cheungpasitporn

“…In the aftermath of the COVID-19 pandemic, the ongoing necessity for preventive measures such as mask-wearing and vaccination remains particularly critical for organ transplant recipients, a group highly susceptible to infections due to immunosuppressive therapy. …”
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Upskilling or deskilling? Measurable role of an AI-supported training for radiology residents: a lesson from the pandemic by Mattia Savardi, Alberto Signoroni, Sergio Benini, Filippo Vaccher, Matteo Alberti, Pietro Ciolli, Nunzia Di Meo, Teresa Falcone, Marco Ramanzin, Barbara Romano, Federica Sozzi, Davide Farina

“…Abstract Objectives This article aims to evaluate the use and effects of an artificial intelligence system supporting a critical diagnostic task during radiology resident training, addressing a research gap in this field. …”
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Combined use of zoophytophagous mirids for sustainable biological protection of greenhouse tomato crops by Kouassi A. J. Konan, Coline C. Jaworski, Lucie S. Monticelli, Mnqobi Zuma, Roger Boll, Marie-France N. Kouadio, Thibaud Martin, Benjamin Gard, Roselyne Souriau, Anne-Violette Lavoir, Nicolas Desneux

“…The presence of D. errans was critical to reduce N. tenuis population growth and necrotic rings on tomato plants, while higher densities of M. pygmaeus density reduced the rate of aborted flowers by N. tenuis. …”
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Edge-Preserving Probabilistic Downsampling for Reliable Medical Segmentation in Resource-Constrained Environments by Shahzad Ali, Yu Rim Lee, Soo Young Park, Won Young Tak, Soon Ki Jung

“…This study introduces a novel approach, Edge-Preserving Probabilistic Downsampling (EPD), designed to retain critical details and bridge the performance gap between networks trained on original and downsampled resolutions. …”
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