Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator by Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda, Santosh Aryal

“…Maximizing delivery of CMPI would enhance its interaction with brain nAChRs that are associated with the desired therapeutic effects while avoiding interactions with peripheral nAChRs that are associated with undesired side effects is critical to the development of nAChR PAM-based therapeutics. …”
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Cloud-edge hybrid deep learning framework for scalable IoT resource optimization by Umesh Kumar Lilhore, Sarita Simaiya, Yogesh Kumar Sharma, Anjani Kumar Rai, S. M. Padmaja, Khan Vajid Nabilal, Vimal Kumar, Roobaea Alroobaea, Hamed Alsufyani

“…Abstract In the dynamic environment of the Internet of Things (IoT), edge and cloud computing play critical roles in analysing and storing data from numerous connected devices to produce valuable insights. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Notably, single-cell analysis revealed that HTTR genes were highly active in CD8 + T cells, with the CXCL12-CXCR4 axis playing a critical role in mediating interactions between CD8 + T cells and endothelial cells. …”
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Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…Abstract Background Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. …”
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The South African Traditional Communities and Women for Rural Democracy and Land Rights by Wandile Brian Zondo

“…The primary objectives are to highlight the critical need for legal reforms that reflect the lived experiences of traditional communities and to advocate for substantive consultations with these communities during legislative and policymaking processes. …”
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Enhancing the strength and toughness of WTaTiVN+Taμm heterogeneous alloys via nano Ti–V–N precipitation phase adjustment by Yifei Hu, Ang Xu, Jilong Liu, Ruoqi Wang, Jinping Suo

“…Addressing the issue of poor toughness due to the intrinsic brittleness of tungsten alloys is critical for their design. In this study, a WTaTiVN system was developed with optimal nitrogen content. …”
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Impact on clinical outcomes, surgical interventions, anaesthetic decisions and complication rates following implementation of the NICE obstructive sleep apnoea guidelines during pr... by Gabrielle Shaw, Ricki Leggatt, Paige Roberts, Amanda Peace Witton, Nicole Moll, Akshay Dwarakanath

“…No significant difference in day case vs non-day case, or need for unplanned admissions to critical care due to better planning pre-procedure. …”
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PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) FISIKA BERBASIS ETNOSAINS MENGGUNAKAN MODEL DISCOVERY LEARNING UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS SISWA SMA by Liza Septiaahmad, Indra Sakti, Iwan Setiawan

“…Keywords: LKPD, Ethnoscience, Discovery Learning, Critical Thinking Skills…”
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Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study by Ibrahim Abdi Abdinasir, Marie Pascaline Sabine Ishimwe, Maxwell Okello, Paul Byaruhanga, Ralph Samson Enyamitoit, Theoneste Hakizimana

“…These findings highlight the critical need for early detection and management of HCA in mothers with PROM, particularly in resource-limited settings. …”
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Public insight into knee osteoarthritis: a cross-sectional study from the West Bank, Palestine by Haya Jebreen Mohammed Warasna, Bashar Yaser Hasan Awad, Mohamad A. Banat, Mohammad Yaser Hasan Awad, Ahmed Farid Gadelmawla, Jameel Suliman, Tarek A. Owais, Ahmad J. Warasna

“…Conclusion This study emphasizes the critical importance of raising awareness and knowledge about osteoarthritis within the Palestinian community. …”
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A new trigonometric-inspired probability distribution: A simulation study and applications in reliability and hydrology by Xiang Tu, Jiangwei Kong, Qing Fu, Sheng Chang, Kunfeng Zhang, Tmader Alballa, Haifa Alqahtani, Hamiden Abd El-Wahed Khalifa

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Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…Although short in quantity, I consider it to be loaded in quality, contents, intents, intensities, and in its ability to problematize a discourse critical to our understanding of indigenous scholarship and all its epistemological implications that span the entire landscape of the humanities. …”
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Hydrochemical assessment of borehole water in Effurun, Delta state Niger Delta, Nigeria: implications for public health and safety by Odunayo Tope Ojo, Chiaka Joy Ike, Adegoke Ige Aladeboyeje, Olayiwola Grace Olaseeni, Olumuyiwa Femi Adewumi

“…Abstract Borehole water plays a critical role in providing drinking water in Effurun, Delta State, Nigeria. …”
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Evolutionary determinants of reproductive seasonality: A theoretical approach by Burtschell, Lugdiwine, Dezeure, Jules, Huchard, Elise, Godelle, Bernard

“…Our results further highlight the critical importance of life history pace on the evolution of reproductive seasonality. …”
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Identifying the Latitude and Longitude of ATMs in ATM Networks by Niloofar Haghjoo, Mohammad rahmati, Ali Zare Mirakabad

“…Objective The geographical positioning of Automated Teller Machines (ATMs) is a pivotal data point that significantly aids in the analytical process and decision-making for a multitude of critical banking and economic determinations. Given the constraints imposed by the insular viewpoint prevalent in the nation’s banking ecosystem, maintaining a consolidated perspective of all ATMs’ geographical locations is not feasible. …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…With only 4.4% of participants achieving optimal HbA1c levels, the findings underscore a critical public health concern regarding the management of diabetes in this vulnerable population. …”
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Development of a Web-Based Intervention for Middle Managers to Enhance Resilience at the Individual, Team, and Organizational Levels in Health Care Systems: Multiphase Study by Eva Gil-Hernández, Irene Carrillo, Jimmy Martin-Delgado, Daniel García-Torres, José Joaquín Mira

“…Phase 1 involved designing the content for the web-based tool based on a comprehensive review of critical elements around resilience. Phase 2 included validation by an international panel of experts who reviewed the tool and rated it according to a structured grid. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…This study highlights the critical role of PTEN in RCC progression and suggests potential therapeutic targets for intervention.…”
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Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study by Gang Wei, Cheng Zhang, Feng-Jie Shen, Hua-Qi Guo, Lin Liu

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Space-time Characteristics of 16 PM2.5-bound Phthalates (PAEs) in Ambient Air from Shanghai: Profiles, Sources, Meteorological Effects, and Exposure Risks by Janvier Munyaneza, Md Faysal Hossain, Qilong Jia, Yusen Duan, Guangli Xiu

“…Daily mean and median concentrations comprising all the species (Σ16PAEs) were generally higher in samples collected during colder periods (38.3 and 37.5 ng m−3, respectively) rather than within samples gathered in warmer periods (31 and 26.9 ng m−3, respectively), though there wasn’t a statistically significant difference between mean concentrations for both periods (ANOVA: p > 0.05, F stat. < F critical). Statistically significant correlations were found between temperature and concentrations of both DBP and Σ16PAEs (p < 0.05, r = 0.34 and 0.35, respectively). …”
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