Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization by Danyue Li, Weilv Xu, Suhui He, Xinyue Li, Yumeng Wang, Qian Lv, Nan Chen, Lu Dong, Feng Guo, Fushan Shi

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Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…Understanding the mechanisms of periodontitis, particularly the role of hypoxia in inflammation, is critical for identifying novel therapeutic strategies. …”
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Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Taken together, our study uncovers Fic genes as potential virulence factors in Fap2+ fusobacterial genomes.IMPORTANCEAccumulating data support that bacterial members of the intra-tumoral microbiota critically influence colorectal cancer progression. …”
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End-tidal carbon dioxide-guided extracorporeal cardiopulmonary resuscitation improves neurological prognosis in patients: a single-center retrospective cohort study by Xiaozu Liao, Chen Gu, Zhou Cheng, Kepeng Liu, Qing Yin, Binfei Li

“…Ensuring high-quality Cardiopulmonary Resuscitation (CPR) before initiating Extracorporeal Membrane Oxygenation (ECMO) is critical to mitigate tissue hypoxia and ischemia. This study aimed to evaluate the effect of End-Tidal Carbon Dioxide (ETCO2) Goal-Directed CPR (GDCPR) on neurological function before ECMO using a retrospective case-control analysis. …”
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Prediction of drought-flood prone zones in inland mountainous regions under climate change with assessment and enhancement strategies for disaster resilience in high-standard farml... by Yongheng Shen, Qingxia Guo, Zhenghao Liu, Yanli Shen, Yikun Jia, Yuehan Wei

“…Predicting drought and flood disaster-prone alternating zones and enhancing cropland disaster resilience are critical for agricultural water management, mitigating meteorological disaster risks, and ensuring food security. …”
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Top health service concerns: a data mining study of the Shanghai health hotline by Lili Shi, Tong Zhao, Shimiao Shi, Tianyu Tan, Aksara Regmi, Yuyang Cai

“…The top 10 health service concerns identified in Shanghai included medical staff attitudes, medications, fees, registration, family planning, medical disputes, ambulance services, environmental health, illegal medical practices, and immunization.ConclusionsThis study not only identifies critical issues within the Shanghai health service system but also offers actionable insights to inform targeted policy interventions. …”
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Air Pollution Levels Related to Peak Expiratory Flow Rates among Adult Asthmatics in Lampang, Thailand by Wanwisa Chujit, Phongtape Wiwatanadate, Athavudh Deesomchok, Khajornsak Sopajaree, Kamal Eldeirawi, Ying I. Tsai

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Personal, environmental and behavioral predictors associated with online fraud victimization among adults. by Vimala Balakrishnan, Umayma Ahhmed, Faris Basheer

“…<h4>Implications</h4>The emergence of Overconfidence and Social Influence as significant predictors can guide the development of targeted online fraud awareness campaigns and/or tools emphasizing critical thinking and skepticism. Policymakers can leverage this knowledge to implement regulations that reduce deceptive practices online, promote digital literacy programs, and mandate clearer consumer protections to mitigate the impact of social manipulation and overconfidence on fraud victimization.…”
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Causal machine learning models for predicting low birth weight in midwife-led continuity care intervention in North Shoa Zone, Ethiopia by Wudneh Ketema Moges, Awoke Seyoum Tegegne, Aweke A. Mitku, Esubalew Tesfahun, Solomon Hailemeskel

“…Abstract Background Low birth weight (LBW) is a critical global health issue that affects infants disproportionately, particularly in developing countries. …”
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STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

“…Enhancement of tumor infiltrating lymphocyte (TIL) is a critical element of efficacious therapy and one that may be achieved via administration of agents that promote tumor vascular normalization (VN) and/or induce the development of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).Methods Low-dose stimulator of interferon genes (STING) agonist ADU S-100 (5 µg/mouse) was delivered intratumorally to established subcutaneous B16.F10 melanomas on days 10, 14 and 17 post-tumor inoculation. …”
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Evaluation of recombinant proteins <i>T. pallidum</i> Тр0163 and Тр0971 as antigens for the diagnosis of syphilis using enzyme immunoassay by Natalia V. Arbuzova, Marina V. Shpilevaya, Georgii L. Katunin, Oleg E. Kuznetsov, Nikita Yu. Nosov, Viсtoria S. Solomka

“…To characterize the antibody concentration, a positivity coefficient was determined as the ratio of the optical density obtained for each sample to the critical optical density. The positivity coefficient was used to determine the difference between groups of syphilis patients and healthy individuals using the Mann-Whitney test for unpaired samples, as well as to assess the clinical informativeness of the laboratory test. …”
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Assessing awareness and treatment knowledge of preventable blindness in rural and urban South African communities by Z Kiva, J E Wolvaardt

“…Addressing this knowledge gap regarding the causes and symptoms of blindness and the treatment options is a critical first step for awareness programmes in rural areas. …”
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Translation, content validity and internal structure of the Brazilian version of the Adolescent Resilience Questionnaire (B-ARQ). by Genara Brum Gomes, Luisa Gatti-Reis, Matheus França Perazzo, Marisa Alves Araújo, Flávio Freitas Mattos, Deirdre Gartland, Saul Martins Paiva, Isabela Almeida Pordeus

“…One scale showed a ceiling effect (frequency higher than 15.0%), but we identified no critical floor effect. The B-ARQ-SV is a valid (in terms of content and structural validity) and reliable (in terms of internal consistency) measurement instrument to assess resilience in Brazilian adolescents.…”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

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Effect of polishing methods on Candida albicans adhesion and contributing factors in heat-cured acrylic dentures: an in-vitro comparative study by Shahrukh Ali Khan, Zulfiqar Ali Mirani, Taimur Khalid, Engr Muhammad Wasiq Ali Khan, Ziaullah Choudhary, Syed Murtaza Raza Kazmi

“…While polishing techniques improve surface smoothness, their effects on water sorption and free surface energy, which are critical to microbial adhesion, remain understudied. …”
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The role of C-reactive protein in predicting all-cause mortality among Chinese arthritis patients: implications for public health education and promotion by Shuchao Ye, Damei Ye, Changyi Lin, Dongming Lu, Xuelan You, Chaoyan Xu, Yongyang Wu

“…C-reactive protein (CRP), a key inflammatory biomarker, plays a critical role in monitoring disease progression and guiding health promotion strategies. …”
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Multicenter Surveillance of Pseudomonas aeruginosa Isolates From Blood: Clinical Distribution Characteristics and Antibiotic Resistance Trends in Hebei Province, China (2016&ndash;... by Qiang C, Liu X, Qin P, Wen H, Li Z, Yang J, Niu Y, Wang W, Ouyang Z, Zhao M, Li J, Zhang Y, Zhao J

“…Predominantly, patients were in the hematology (20.7%) and critical care medicine (18.4%) departments. During the monitoring period, the resistance rate of P. aeruginosa to various antibacterial drugs, such as aminoglycosides, fluoroquinolones, and carbapenems, decreased to varying degrees, with an average resistance rate of less than 20.0% over six years. …”
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Investigation of Potential Profiles and Influencing Factors of Voice Behavior among Chinese Nurses by Shuangying Huang, Hanwen Chen, Liyan Zhang, Xianming Weng, Lingming Zhou, Xiaoqin Ma, Weiyi Wang

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Evaluating pre-processing and deep learning methods in medical imaging: Combined effectiveness across multiple modalities by Thien B. Nguyen-Tat, Tran Quang Hung, Pham Tien Nam, Vuong M. Ngo

“…Medical imaging is critical in modern healthcare for accurately detecting and diagnosing various medical conditions. …”
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The assessment of routine health information system performance towards improvement of quality of reproductive, maternal, newborn, child and adolescent health services in Ondo and... by Victoria Oladoyin, Sunday Adedini, Kayode Ijadunola, Hassan Ogunwemimo, Olubunmi Folorunso, Elizabeth Chukwu, Ugo Okoli, Anthony Adoghe, Samuel Oyeniyi, Oniyire Adetiloye, Adesegun Fatusi

“…Using the routine health information system performance diagnostic tool, service data captured for over one year were critically reviewed in randomly selected sample of 169 public health facilities (Ondo:117; Ekiti:52) and information was obtained from facility heads or designates. …”
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