Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Functional studies in Rax-CreERT2 transgenic mice confirmed that Itgb1 plays a critical role in maintaining the balance of hypothalamic GnRH–tanycyte unit during EA treatment. …”
Get full text

A20 as a Potential Therapeutic Target for COVID‐19 by Yongyao Wu, Lilan He, Rong Li, Jiuxuan Li, Qing Zhao, Bin Shao

“…Results A20 might be one of the most critical anti‐infectious and anti‐inflammatory factors involved in the pathogenesis of COVID‐19. …”
Get full text

Dynamic responses characteristics of bedrock and overburden layer slope with anchored frame piles based on shaking table test by Lei Wang, Qianhui Pu, Guangpeng Chen, Jing Lian, Changwei Yang, Mingming Dai

“…Below the sliding surface of the front pile and on top of the bedrock of the back pile are the critical areas for prevention and control. Elevating the prestressing of the anchor cables will help enhance the synergy between the anchor cables and the piles. …”
Get full text

Analysis of the relationship between abdominal aortic calcification and frailty in the middle-aged and older US population by Rena Rehemuding, Kaisaierjiang Kadier, Xinliang Peng, Pengfei Liu, Diliyaer Dilixiati, Aikeliyaer Ainiwaer, Xiaozhu Liu, Xiangtao Liu, Xiang Ma

Get full text

A systematic review of military-to-civilian transition, The role of gender. by Alexandria Smith, Laura Rafferty, Bethany Croak, Neil Greenberg, Rafiyah Khan, Victoria Langston, Marie-Louise Sharp, Anne Stagg, Nicola Fear, Sharon Stevelink

“…An assessment of study quality was conducted using the Joanna Briggs Institute (JBI) Qualitative Critical Appraisal Checklist for Qualitative Studies. …”
Get full text

Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

Get full text

A study to correlate the association of Gender, Age, Physiology (GAP) index and radiological patterns in interstitial lung disease by Aditya Shashi Bhushan, B L Shashibhushan, K Ashwin

“…High-resolution computed tomography (HRCT) is a critical diagnostic tool that provides detailed information on lung morphology and disease extent. …”
Get full text

Spondylolisthesis and Scoliosis Progression and Associated Revision Rates Following Bilateral Lumbar Spine Microscopic Decompression by Walter-Soon-Yaw Wong, Ashton Kai Shun Tan, Kenneth Zhi Kuan Loi, Dhivakaran Gengatharan, Craigven Hao Sheng Sim, Hao Bin Chen, Yilun Huang

“…Although the optimal extent of decompression remains a critical consideration, limited evidence-based guidelines define the threshold for instrumented fusion to maintain biomechanical stability. …”
Get full text

Multistate Markov model application for blood pressure transition among the Chinese elderly population: a quantitative longitudinal study by Bin Zhao, Juan Xiong, Yuxin Wang, Xujuan Zheng, Yiqin Zhang, Liping Xu, Lina Zhou

“…Increasing age, BMI and glucose were critical risk factors for developing hypertension. …”
Get full text

An analysis of observed and predicted extreme heat and precipitation trends across four pulse producing regions in North America: North Dakota, Montana, Saskatchewan, and Northeast... by Sophia Weiss, Erin Coughlan de Perez

“…As the demand for plant-based proteins, like pulse crops, continues to grow, it is critical to understand the impact of climate change on crop production. …”
Get full text

Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…This study presents the development and validation of a sensitive LC-MS/MS method for the simultaneous quantification of tadalafil and macitentan in rat plasma, enabling detailed pharmacokinetic profiling following single-dose administration. Optimization of critical parameters, including organic phase composition (50% acetonitrile), flow rate (1.0 mL/min), and pH (3.2), was achieved using a Box-Behnken Design, ensuring accurate separation and quantification. …”
Get full text

Le sensorium synthétique : réflexion sur l’utilisation de l’expographie immersive numérique et muséale by Dominique Gélinas

“…I have tried to identify the main ideas emerging from the museum sector relating to remediated immersive digital exhibits. I end with a critical stance that questions digital immersion in itself. …”
Get full text

Trends and determinants of obesity among ever-married women aged 15–49 in India: insights from National Family Health Surveys (NFHS 1998–2021) by Aditya Singh, Sadanand Karun, Mahashweta Chakrabarty, Rakesh Chandra, Shivani Singh

“…Prioritizing vulnerable groups, including the poor, uneducated, and urban populations, is critical for ensuring fair health outcomes.…”
Get full text

Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Furthermore, weighted correlation network analysis (WGCNA) and gene set enrichment analysis (GSEA) identified EMT as a top enriched pathway in patients with high POSTN expression, suggesting it may play a critical role in radiotherapy resistance. Subsequently, in vitro experiments confirmed that POSTN knockdown significantly inhibited HeLa cell proliferation, invasion, and enhanced radiosensitivity, while promoting apoptosis. …”
Get full text

Enhanced vehicle routing for medical waste management via hybrid deep reinforcement learning and optimization algorithms by Norhan Khallaf, Osama Abd-El Rouf, Abeer D. Algarni, Mohy Hadhoud, Ahmed Kafafy

“…Despite this trade-off, the algorithm’s ability to minimize fleet size while fully utilizing vehicle capacity makes it the optimal choice in scenarios where these factors are critical. This approach not only improved performance but also enhanced environmental sustainability, making it the most effective and challenging solution among all the algorithms used in the study.…”
Get full text

Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…Identifying and implementing early and adequate therapy are critical for improving clinical outcomes. The burden of JIA on affected children, their families, and the healthcare system in Spain has not been adequately assessed. …”
Get full text

Expression and correlation of endoglin, sEndoglin, and MMP-14 on preeclampsia placenta by Febriana Catur Iswanti, Ninik Mudjihartini, Reni Paramita, Yuditiya Purwosunu, Ani Retno Prijanti

“…Angiogenic imbalance plays a critical role in placental ischemia, a hallmark of preeclampsia. …”
Get full text

China’s CBM exploration and production and associated technological advancements: A review and reflections by Jianping YE

“…Objective and Methods Based on extensive scientific and technical literature and technical data on coalbed methane (CBM) exploration and production projects, this study conducted a comparative analysis of the development process and latest advances in China’s critical technologies for CBM exploration and production and reviewed the CBM exploration and production history of this country over the past three decades. …”
Get full text

Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

Get full text

A Low Complexity Dual-Phase Alternating Scheme is Used With the PTS Method to Reduce PAPR for B5G Systems by Yung-Ping Tu, Chen-Wei Hsu

“…It can significantly reduce the computational complexity due to only being made in the simple amplitude phase-reverse operation for maximum <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula> critical amended subcarriers. Simulation results show that the proposed scheme achieves better PAPR performance and computational complexity regardless of the waveform than previous well-known techniques, such as PTS, selective mapping (SLM), etc. …”
Get full text