Pre-diabetes and cardiovascular risk factors in NAFLD patients: a retrospective comparative analysis by Azam Teimouri, Zahra Ebrahimpour, Awat Feizi, Bijan Iraj, Elahe Saffari, Mojtaba Akbari, Mozhgan Karimifar

“…ObjectivesInsulin resistance plays a critical role in the pathophysiology of diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). …”
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Outbreak of carbapenem resistant Klebsiella pneumoniae in a neurorehabilitation unit: Genomic epidemiology reveals complex transmission pattern in a tertiary care hospital by Maria Grazia Silvotti, Erika Scaltriti, Luca Bolzoni, Beatrice Zerbi, Gabriella Tocci, Andrea Zappavigna, Gianfranco Lamberti, Federico Donati, Franco Federici, Stefano Pongolini, Giuliana Lo Cascio

“…The study highlights the critical role of genomic epidemiology in hospital outbreaks. © 2025 The Author(s). …”
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Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting by Rachel D. Altshuler, Megan A. M. Burke, Kristine T. Garcia, Kenneth Class, Raffaello Cimbro, Xuan Li, Xuan Li

“…We previously demonstrated a critical role of dorsal striatum (DS) in this incubation in rats. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“… OBJECTIVE: Umbilical cord usually seems simple functionally and structurally but it's the life link between fetus and mother that was critically important for growing fetus. The aim of this study is to evaluate the effect of early umbilical cord coiling index on perinatal outcomes. …”
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Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans by Benjamin R Kop, Yazan Shamli Oghli, Talyta C Grippe, Tulika Nandi, Judith Lefkes, Sjoerd W Meijer, Soha Farboud, Marwan Engels, Michelle Hamani, Melissa Null, Angela Radetz, Umair Hassan, Ghazaleh Darmani, Andrey Chetverikov, Hanneke EM den Ouden, Til Ole Bergmann, Robert Chen, Lennart Verhagen

“…Primarily, this study highlights the substantial shortcomings in accounting for the auditory confound in prior TUS-TMS work where only a flip-over sham and no active control was used. The field must critically reevaluate previous findings given the demonstrated impact of peripheral confounds. …”
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Small molecule metabolites drive plant rhizosphere microbial community assembly patterns by Yanwei Ma, Heqi Wang, Yalong Kang, Tao Wen

“…Seven small molecule metabolites, including glycerol, sorbitol, phytol, and alpha-ketoglutaric acid, were significantly correlated with βNTI, underscoring their role as critical drivers of microbial community assembly. The genus Rhizobium, significantly associated with βNTI (R = 0.25, p = 0.009), emerged as a keystone taxon shaping community structure. …”
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The concentration of selected organophosphorus pesticides associated with PM10 in agricultural ambient air in Iran: Health risk assessment using Monte Carlo simulation by Asma Tabanasl, Amin Mohammadpour, Aboozar Soltani, Mohammad Hoseini, Mohammadali Baghapour

“…Notably, the concentration of Diazinon and its interaction with inhalation rates were critical determinants of HI, while Malathion concentration and its interaction with inhalation rates significantly impacted CR for both demographic groups. …”
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Deciphering the multifaceted mechanism of Shuang Huang Lian in treating upper respiratory tract infections: A metabolomics-based network pharmacology approach by Gang Xu, Akshay Suresh Patil, Ruhan Wei, Dan Liu, Aimin Zhou, Yan Xu

“…Results: Our analysis identified TNF, CASP1, and MAPK14 as pivotal protein targets in SHL's action against URTIs, with brusatol, an active SHL component, confirmed as a critical ligand that modulates these targets. Conclusion: This comprehensive study elucidates the multifaceted mechanisms underlying SHL's efficacy in treating URTIs, supporting its traditional use and highlighting its potential for novel therapeutic development.…”
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Optimization and potential assessment of CO2 geological storage caprock in the saline aquifers of the Qingjiang Basin, middle and lower reaches of the Yangtze River by Yuchen Tian, Shiqi Liu, Sijian Zheng, Shuxun Sang, Yinghai Liu, Shiheng Chen, Helong Zhang, Yanzhi Liu, Yuntian Jiang, Zekun Yue, Wenkai Wang

“…This analysis provided critical geological factor evaluations for CO2 storage. …”
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Molecular mechanisms induced by phase modifiers used in hydrometallurgy: consequences on transfer efficiency and process safety by El Maangar, Asmae, Prévost, Sylvain, Dourdain, Sandrine, Zemb, Thomas

“…It is a matter of strategic independence for many countries to urgently find processes that take into account environmental and economic issues when recycling critical metals. Liquid–liquid (L/L) extraction is a promising method for recovering rare-earth elements from electrical and electronic waste. …”
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Learnings from COVID-19 Forced Lockdown on Regional Air Quality and Mitigation Potential for South Asia by Abhishek Upadhyay, Parth Sarathi Mahapatra, Praveen Kumar Singh, Sishir Dahal, Suresh Pokhrel, Amit Bhujel, Indu Bikram Joshi, Shankar Prasad Paudel, Siva Praveen Puppala, Bhupesh Adhikary

“…Abstract South Asia is a hotspot of air pollution with limited resilience and hence, understanding the mitigation potential of different sources is critically important. In this context the country lockdown initiated to combat the COVID-19 pandemic (during March and April 2020 that is the pre-monsoon season) provides an unique opportunity for studying the relative impacts of different emission sources in the region. …”
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“Sleepless nights are a daily reality for us” how women experiencing homelessness in Addis Ababa, Ethiopia describe street life: a photovoice study by Kalkidan Yohannes, Kalkidan Yohannes, Kalkidan Yohannes, Mats Målqvist, Hannah Bradby, Yemane Berhane, Dagmawit Tewahido, Dagmawit Tewahido, Sibylle Herzig van Wees, Sibylle Herzig van Wees

“…They also emphasised the critical need for employment opportunities, non-discriminatory provision of social support, treatment programs for substance misuse, and legal and social protection.ConclusionThis study contributes to understanding how women experiencing homelessness describe and articulate their living circumstances and what they perceive needs to be addressed. …”
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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…Conclusions: Community-onset BSIs demonstrated substantial prevalence of resistant pathogens, including ESBL and MRSA, emphasizing the need for robust surveillance systems. Age is a critical factor in guiding empirical antibiotic therapy in the ED.…”
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Impacts of Pta-AckA pathway on CPS biosynthesis and type 3 fimbriae expression in Klebsiella pneumoniae by Tien-Huang Lin, Chen-Yu Wang, Chien-Chen Wu, Ching-Ting Lin

“…Conclusion: Our findings highlight the critical role of the Pta-AckA pathway in K. pneumoniae pathogenesis. …”
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The iGains4Gains model guides irrigation water conservation and allocation to enhance nexus gains across water, food, carbon emissions, and nature by Bruce Lankford, Nafn Amdar, Matthew McCartney, Tafadzwanashe Mabhaudhi

“…The model addresses two critical questions regarding increased irrigation efficiency. …”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

“…Understanding historical patterns of forest cover change (FCC) is critical for predicting future trends and informing sustainable management strategies. …”
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Genotyping of extended-spectrum beta-lactamase-producing Escherichia coli isolated from wastewater of dairy farms in East Java, Indonesia by Fidi Nur Aini Eka Puji Dameanti, Sheila Marty Yanestria, Mustofa Helmi Effendi, Hani Plumeriastuti, Wiwiek Tyasningsih, Emmanuel Nnabuike Ugbo, Rahayu Sutrisno, Muhammad Ali Akramsyah Safri

“…Conclusion: The identified molecular profiles underscore dairy farm wastewater as a critical reservoir for antibiotic resistance genes, particularly blaTEM. …”
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Prediction of Soil Organic Carbon Content in <italic>Spartina alterniflora</italic> by Using UAV Multispectral and LiDAR Data by Jiannan He, Yongbin Zhang, Mingyue Liu, Lin Chen, Weidong Man, Hua Fang, Xiang Li, Xuan Yin, Jianping Liang, Wenke Bai, Fuping Li

“…The results show that the following. 1) The prediction accuracy is improved by classifying the data into three types: unlodging <italic>S. alterniflora</italic> (ULSA), lodging <italic>S. alterniflora</italic> (LSA), and mudflats. 2) XGBoost outperformed RF and SVM in accurately predicting SOC content, with <italic>R</italic>²; values of 0.743 for ULSA, 0.731 for LSA, and 0.705 for mudflats; 3) In the XGBoost models constructed for ULSA, LSA, and mudflats, spectral features contributed 75.7&#x0025;, 73.1&#x0025;, and 63.1&#x0025;, respectively, with the normalized difference vegetation index emerging as the most critical spectral feature. Slope aspect (AS) was identified as the most influential topographic feature. 4) The spatial distribution of SOC exhibited marked heterogeneity, with higher SOC content in ULSA and lower in mudflats, demonstrating a gradient of decreasing SOC content from land to sea. …”
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Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study by Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

“…The GCS score and arterial pH are critical biomarkers for assessing the severity of ANE.…”
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Cochlear implantation in vestibular schwannoma: A game changer? A narrative review by Luis Lassaletta, Miryam Calvino, Isabel Sánchez-Cuadrado, José Manuel Morales-Puebla, Javier Gavilán

“…Methods: A Pubmed search was performed, with a selection of relevant citations, and critical appraisal of selected studies. Articles written in English on VS and cochlear implantation were eligible for inclusion. …”
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