The Efficacy of the Mulligan Concept to Treat Meniscal Pathology: A Systematic Review by Nathan C. Reep, Sydney N. Leverett, Rebecca M. Heywood, Russell T. Baker, Darren L. Barnes, Scott W. Cheatham

“… # Hypothesis/Purpose The purpose of this systematic review was to critically appraise the literature to investigate the effectiveness of MC MWMs for meniscal lesions on patient reported pain, function, and multi-dimensional health status in patients with clinically diagnosed meniscal pathologies…”
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Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk by Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang, Jianguo Zhang

“…Abstract Background The liver‒brain axis is critical in neurodegenerative diseases (NDs), with lipid metabolism influencing neuroinflammation and microglial function. …”
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Osteoarthritis of the knee joint and its association with metabolic syndrome: A case control study by Rohini Motwani, Arvind Kumar Bodla, Shravan Kumar Peddamadyam, Mrudula Chandrupatla, Nagesh Cherukuri, Maheshwar Lakkireddy, Gunvanti Rathod, Sai Ram Challa, Chowdavarapu Raghavendra Rao, Abhishek Arora, Srikanth Eppakayala, Arcot Reddy Vamsi Krishna

“…It might also emphasize how critical it is to treat MetS symptoms to lessen the severity of OAK. …”
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Determining the alignment of assessment items with curriculum goals through document analysis by addressing identified item flaws by Humaira Fayyaz Khan, Shazia Qayyum, Huma Beenish, Rehan Ahmed Khan, Samina Iltaf, Lubna Rani Faysal

“…Document analysis identified misalignments between content objectives, cognitive processes, and assessment strategies, which compromise the quality of evaluations and can hinder the development of critical thinking and problem-solving skills. To address these issues, we propose integrating identified flaws into institutional guidelines and implementing an updated checklist for pre-hoc evaluation of assessment items, with a focus on curriculum alignment and cognitive levels.…”
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Organ Donation Conversations on X and Development of the OrgReach Social Media Marketing Strategy: Social Network Analysis by Wasim Ahmed, Mariann Hardey, Josep Vidal-Alaball

“…With a global rise in organ transplant needs, fostering public understanding and positive attitudes toward organ donation is critical. Social media platforms, such as X, contain conversations from the public, and key stakeholders maintain an active presence on the platform. …”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

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Mitigating drought stress in fenugreek through synergistic effects of alanine and potassium-enriched biochar by Wanzheng Ma, Xinyu Fang, Mengru Qiu, Misbah Hareem, Zeki Erden, Çağdaş Can Toprak, Abdullah A. Alarfaj

“…It can decrease seed germination, biomass accumulation, root proliferation, chlorophyll contents, and stomatal conductance. To overcome this critical issue, researchers suggest employing environmentally friendly approaches. …”
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Exploring the prognostic role of microbial and genetic markers in lung squamous cell carcinoma by Fan Yang, Xiaodong Jia, Zihuan Ma, Siyao Liu, Chunzi Liu, Dan Chen, Xiuju Wang, Niansong Qian, Hui Ma

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Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

“…We will include all critically ill adults (aged≥18 years) and any ICU delirium prevention or management intervention (pharmacological or non-pharmacological). …”
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Overcoming barriers for investigating nickel-pincer nucleotide cofactor-related enzymes by Jorge L. Nevarez, Aiko Turmo, Santhosh Gatreddi, Swati Gupta, Jian Hu, Robert P. Hausinger

“…The methods discussed here further our abilities to investigate the unique activities of Lar proteins.IMPORTANCEEnzymes containing the nickel-pincer nucleotide (NPN) cofactor are prevalent in a wide range of microorganisms and catalyze various critical biochemical reactions, yet they remain underexplored due, in part, to limitations in current research methodologies. …”
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How many trees to see the forest? Assessing the effects of morphospace coverage and sample size in performance surface analysis by Stephanie M. Smith, C. Tristan Stayton, Kenneth D. Angielczyk

“…Abstract Linking morphology and function is critical to understanding the evolution of organismal shape. …”
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Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Here, we evaluate the potential of this method to identify host-toxin interactions on the cell surface and in the cytosol, where the toxin modifies essential host targets. Critically, we have highlighted several limitations of this method as applied to protein toxins, which are important for researchers to weigh when considering this technique for exotoxin studies.…”
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PEDAGOGICAL CONDITIONS FOR THE FORMATION OF AN EFFECTIVE INFORMATION AND LEARNING ENVIRONMENT IN HIGHER EDUCATION INSTITUTIONS by Valerii Yu.  Habrusiev, Hryhorii V. Tereshchuk, Alla V. Stepanyuk, Tetiana M. Olendr

“…The core idea  is the idea of content modelling based on the combination of key competences of the 21st century «4 С» (critical thinking, creativity, collaboration, communication) with digital competence and the ability to predict the possibilities of developing a modern educational environment in the future. …”
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Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…Background: Early screening is critical for the prevention of ischemic stroke. miR-574–5p was considered a promising biomarker for ischemic stroke but lacks direct confirmation. …”
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CSF shunts as conduits for metastasis: is there a discrepancy between retrograde and antegrade spread? by Andrea Cuschieri, Robert Pisani, Shawn Agius

“…The JBI case report critical appraisal tool assessed reporting quality. …”
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders by Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey

“…In this review, we highlight the critical role of the GlyR α2 subunit revealed by knockout mice and our current understanding of GlyR α2 pathomechanisms in human NDDs. …”
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Nurses' knowledge and its determinants in surgical site infection prevention: A comprehensive systematic review and meta-analysis. by Tesfaye Engdaw Habtie, Sefineh Fenta Feleke, Aregash Birhan Terefe, Addis Wondmagegn Alamaw, Melsew Dagne Abate

“…While the pooled odds ratio is not statistically significant, training, longer service years, and higher education improve SSI prevention knowledge by enhancing critical thinking, boosting confidence, and fostering adherence to evidence-based practices. …”
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Acceptability of telemedicine for early surgical site infection diagnosis after cesarean delivery in rural Rwanda: a qualitative study by Laban Bikorimana, Eve Hiyori Estrada, Anne Niyigena, Robert Riviello, Fredrick Kateera, Bethany Hedt-Gauthier, Vincent K. Cubaka

“…Trust in CHWs emerged as a critical factor for community acceptance. While one CHW expressed reservations about implementing the intervention during COVID-19, the majority of CHWs and patients indicated strong acceptance, with some even preferring it. …”
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Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum by Mitchell L. Trickey, Mrittika Chowdury, Georgina Bramwell, Natalie A. Counihan, Tania F. de Koning-Ward

“…Abstract Background Malaria parasites establish new permeation pathways (NPPs) at the red blood cell membrane to facilitate the transport of essential nutrients from the blood plasma into the infected host cell. The NPPs are critical to parasite survival and, therefore, in the pursuit of novel therapeutics are an attractive drug target. …”
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Tillage and residue management modulate the links between soil physical signatures and arbuscular mycorrhizal fungal biomarkers by Stamatios Thomopoulos, Lars Juhl Munkholm, Lars Elsgaard, Sabine Ravnskov

“…Minimal soil disturbance enhanced wet aggregate stability by 14 % on average but negatively affected pore characteristics. AMF played a critical role in soil aggregate stability, evidenced by a strong correlation (r = 0.68 and r = 0.86 in the two sites) between hyphal networks and WSA. …”
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