Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…Further, we elucidate the critical role of FGF signaling in odontoblast maturation and its biomineralization capacity using the de novo designed FGFR1/2c isoform specific minibinder scaffolded as a C6 oligomer that acts as a pathway agonist. …”
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Harnessing Meta-Reinforcement Learning for Enhanced Tracking in Geofencing Systems by Alireza Famili, Shihua Sun, Tolga Atalay, Angelos Stavrou

“…Effective geofencing relies heavily on precise tracking capabilities, a critical component for maintaining the integrity and functionality of these systems. …”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…If successful, the REASSESS study could demonstrate that reduction of ICH volume is a critical target to reduce the risk of progressive cognitive decline, establish targets for residual haematoma volume reduction and determine if greater residual haematoma volume leads to a long-term inflammatory state.Ethics and dissemination Approval of this study was obtained from the Johns Hopkins University Institutional Review Board (IRB00311985). …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…Given their role in disease transmission, accurate identification of horse fly species is critical but traditionally relies on morphological characteristics, requiring significant expertise and posing a high potential for error, especially with damaged specimens. …”
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Environmental Governance Challenges of Indigenous Forest Recognition: Climate Solution Ideal and Its Uneven Outcomes in Indonesia by Abdurrahman Abdullah, Micah R. Fisher, Muhammad Alif K. Sahide

“…We apply a lens from political ecology and draw from critical research on land and property to identify the unevenness of an emerging climate policy solution. …”
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Measuring above-ground carbon stock using spatial analysis and the InVEST model: application in the Thoria Watershed, India by Zhe Guo, Himani Sharma, Mahesh Jadav, Upeksha Hettiarachchi, Chiranjit Guha, Wei Zhang, Pratiti Priyadarshini, Ruth S Meinzen-Dick

“…Understanding and quantifying above-ground carbon stock is critical for assessing the impact of land use choices on carbon emissions which can inform conservation and management strategies to protect and increase carbon stocks. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…Minimising alcohol consumption and smoking is critical. A hepatotropic drug therapy is most essential in moderate fibrotic NAFLD. …”
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Self-citation pattern among world's top 2 % of the scientists by Berun A. Abdalla, Ayman M. Mustafa, Fattah H. Fattah, Fahmi H. Kakamad, Sami S. Omar, Ameer M. Salih, Aso S. Muhialdeen, Jaafar Omer Ahmed, Rawa Bapir, Shvan H. Mohammed, Karokh K. Mohammed, Hiwa O. Baba, Sasan M. Ahmed, Shevan M. Mustafa, Kayhan A. Najar

“…These findings highlight the dramatic impact of self-citation exclusion on the rankings of the top 2 % of the researchers, underscoring the critical importance of accounting for self-citation in ranking assessments.…”
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LEVEL OF PROCALCITONIN PLASMA AS AN EARLY SEPSIS BIOMARKER IN POLYTRAUMA PATIENTS IN DR HASAN SADIKIN GENERAL HOSPITAL BANDUNG by Ricky Wibowo, Hermawan Nagar Rasyid, Darmadji Ismono

“…Clinical diagnosis and routine laboratory test are not specific until the patient entered a critical state. Delayed diagnosis of sepsis is caused by difficulties in diagnosing. …”
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Genome-wide identification and characterization of transcription factors involved in defense responses against Sclerotinia sclerotiorum in Brassica juncea by Xu Yang, Shaomin Guo, Hairun Jin, Jinze Zhang, Lijing Xiao, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

“…Transcription factors (TFs) are recognized for their critical role in plant defense against S. sclerotiorum. …”
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Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase by Roy J. Rodriguez Carrero, Cody T. Lloyd, Janhavi Borkar, Shounak Nath, Liviu M. Mirica, Satish Nair, Squire J. Booker, William Metcalf

“…Thus, a detailed understanding of this enzyme is critical for the development of methane mitigation strategies.…”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Secretory phospholipase A2 (sPLA2), an inflammatory enzyme, plays a critical role in producing platelet-activating factor (PAF), a key mediator of vascular leak. …”
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Predictive models for the surface roughness and subsurface damage depth of semiconductor materials in precision grinding by Shang Gao, Haoxiang Wang, Han Huang, Zhigang Dong, Renke Kang

“…Additionally, this study identifies variations in elastic recovery and material plasticity as critical factors influencing surface roughness and SDD across different materials. …”
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Cross-Regional Capacity Mechanism for Emergency Power Support in Extreme Weather Events by WU Zifeng, YUAN Jiahai, ZHANG Jian, ZHANG Haonan

“…Based on cross-regional supply and demand theory，the architectural design of the cross-regional capacity mechanism is enhanced by incorporating three critical components： mechanism boundaries and regulations，lower and upper bounds of the capacity compensation price，and frameworks for responsibility and penalties. …”
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Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Objectives Functional impairment is an early stage of disability, and timely identification and intervention are critical for the health of older adults. However, little is known about the functional impairment of Chinese older adults due to the absence of specialised assessment tools. …”
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Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis by Ali Tadayon, Javad Moayedi, Mohamad Ali Nazarinia, Mahyar Malekzadeh, Sara Kazemi, Maryam Mardani

“…Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by T helper 17 (Th17) cells, and plays a critical role in many inflammatory conditions. This study aims to assess the salivary IL-17 levels in Iranian patients with SSc. …”
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CHOLINE TRANSPORTER-RELATED 4 (CTR4) Is Involved in Drought and Saline Tolerance in Rice by Yu Shicong, Luo Ruxian, Zheng Shuqin, Ning Jing, Shi Yuanzhu, Guo Daiming, Jia Liangmeng, Wang Sen, Xiao Guizong, Guo Pengwang, Li Yang, Ma Xiaoding

“…Using MutMap sequencing, we characterized the role of a choline transporter-related family gene, CTR4 (Choline Transporter-Related 4), in rice’s tolerance to drought and salt stress. CTR4 plays a critical role in regulating membrane lipid synthesis. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…Notably, C. auris is classified in the critical priority group on the World Health Organization's fungal priority pathogens list, which highlights fungal species capable of causing systemic infections with significant mortality and morbidity risks as well as the challenges posed by their MDR profiles, limited treatment and management options. …”
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Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and... by Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun

“…Pseudotime analysis confirmed that CD8+ Tex mainly clustered at the end of the differentiation pathways, making them a critical subset in TNBC progression. By analyzing the TCGA cohort, ten CD8+ Tex-related DEGs were identified as significantly correlated with overall survival (OS) in TNBC patients, and a prognostic model containing four biomarkers (GBP1, CTSD, ABHD14B, and HLA-A) was constructed. …”
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Diverse pathways to decarbonization: cluster-specific impacts of energy sources on CO2 emissions in the European Union by Jana Chovancová, Igor Petruška, Ugur Korkut Pata, Peter Adamišin

“…This study provides critical insights for policymakers aiming to meet climate change targets and underlines the urgent need for strategic energy and climate change policies aligned with the unique characteristics of each EU country cluster to facilitate a successful energy transition.…”
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