GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo. by Lara Vojnov, Mauricio A Martins, Jorge R Almeida, Zachary Ende, Eva G Rakasz, Matthew R Reynolds, Enrique J Leon, Kim L Weisgrau, Benjamin J Burwitz, Joy M Folkvord, Marlon G Veloso de Santana, Patrícia C Costa Neves, Elizabeth Connick, Pamela J Skinner, Emma Gostick, David H O'Connor, Nancy A Wilson, Myrna C Bonaldo, Ricardo Galler, David A Price, Danny C Douek, David I Watkins

“…Several lines of evidence suggest that HIV/SIV-specific CD8(+) T cells play a critical role in the control of viral replication. …”
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Multi-objective optimization of SUS430C steel turning process using hybrid machine learning and evolutionary algorithm approach by Nguyen Van-Canh, Nguyen Anh-Thang, Pham Ngoc-Linh, Nguyen Thuy-Duong

“…A hybrid approach combining Extreme Gradient Boosting (XGBoost) and Non-dominated Sorting Genetic Algorithm-II (NSGA-II) was employed to optimize three critical machining objectives: surface roughness (Ra), material removal rate (MRR), and tool wear (Vb). …”
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Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard by Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

“…This has prompted the design of Novel Approach Methods (NAMs) to streamline risk assessment and predict human hazards without relying on animal testing. A critical aspect of advancing NAMs is the urgent need to replace animal-derived products in assay protocols. …”
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Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…An oversampling method was applied to balance the data set.Interventions This study has no interventions.Participants The study included 2379 participants, of whom 507 were diagnosed with AD.Primary and secondary outcome measures Including accuracy, precision, recall, F1 score, etc.Results 11 variables were critical in the training phase, including educational level, depression, insomnia, age, Body Mass Index (BMI), medication count, gender, stenting, systolic blood pressure (sbp), neurosis and rapid eye movement. …”
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The influence of sex on sleep characteristics in the adult and older adult population: findings from the EPISONO sleep study by Mayra dos Santos Silva, Priscila Farias Tempaku, Priscila Farias Tempaku, Monica Levy Andersen, Monica Levy Andersen, Sergio Tufik, Sergio Tufik, Dalva Poyares, Dalva Poyares

“…IntroductionSleep is a restorative behavior and is critical for overall health, but differences in sleep patterns between men and women can be seen over the years.AimTo prospectively analyze the polysomnographic findings of adults and older adults who participated in two editions of EPISONO, according to sex.MethodsThe population-based prospective longitudinal study included 688 individuals. …”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…Decisions at the early optimization stage are critical for the success of the drug candidate but are constrained due to the limited knowledge of the antibody and target pharmacology. …”
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Coupling ICESat-2 and Sentinel-2 data for inversion of mangrove tidal flat to predict future distribution pattern of mangroves by Xiaoyong Ming, Yichao Tian, Qiang Zhang, Yali Zhang, Jin Tao, Junliang Lin

“…Tidal flats represent one of the Earth’s most critical ecosystems characterized by substantial ecological value, but these areas are also among the most fragile ecosystems. …”
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Sulfur partitioning between aqueous fluids and felsic melts at high pressures: Implications for sulfur migration in subduction zones by Lanqin Li, Xingcheng Liu, Ting Xu, Xiaolin Xiong, Jintuan Wang, Li Li

“…Despite its importance, the partitioning of S between aqueous fluids and silicate melts under the conditions of subduction zone, critical for magma generation and evolution, remains poorly understood. …”
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Short-term solar irradiance forecasting using deep learning models by Syed Saad Ahmed, Chang Wei Bin, Nisar Humaira, Riaz Hannan Naseem, Yeap Kim Ho, Zaber Nursaida Mohamad

“…Short-term solar irradiance is a critical area in renewable energy for the optimal operation and power prediction of grid-connected photovoltaic (PV) plants and other solar energy applications. …”
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Allometric models for estimating aboveground biomass and carbon stocks of the semi-arid savanna woody species, Detarium microcarpum Guill. et Perr. by Adama Taonda, Issouf Zerbo, Innocent Charles Emmanuel Traore, Fousseni Folega, Anny Estelle N'Guessan, Justin N'Dja Kassi, Adjima Thiombiano

“…Quantification of plant biomass and carbon is critical for the savanna species. The lack of accurate biomass tools is a challenge for the savanna species. …”
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Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development and examination of neurodevelopment. …”
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Effect of rennet on buffalo cheese microbiota, taste and flavor by Angela M. I. Montone, Angelo Citro, Germana Colarusso, Francesca Garofalo, Rubina Paradiso, Giorgia Borriello, Domenico Vecchio, Federico Capuano

“… Rennet is a critical element that allows the coagulation of milk caseins, the basic process of producing cheese. …”
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Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021... by Yi-Chang Zhao, Ming-Xuan Xiao, Zhi-Hua Sun, Jia-Kai Li, Huai-yuan Liu, Bi-Kui Zhang, Hua-Lin Cai, Wei Cao, Feng Yu, Miao Yan

“…Abstract Background The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. …”
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Charge-on-the-move solutions for future mobility: A review of current and future prospects by Mohd Aiman Khan, Wilco Burghout, Oded Cats, Erik Jenelius, Matej Cebecauer

“…Dynamic charging enables EVs to recharge while in motion, presenting opportunities to minimize battery sizes, reduce emissions, and optimize operational efficiency. The study critically evaluates state-of-the-art dynamic charging technologies, including their benefits, limitations, and applicability to future mobility systems, while also comparing these solutions based on infrastructure costs, readiness, and scalability. …”
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Towards fiscal sustainable practices in Mexico: The quality of municipal tax regulation and tiered tariffs improve income from solid waste management services by Sergio López-Olvera, Juan Carlos Olivo-Escudero, Mauricio Hernández-Marroquín, Fausto Rafael López-Olvera, Yessica Lourdes Vallejo-Rivera, Marco Antonio Rodríguez-Gómez, Pedro Hipólito Rodríguez-Herrero

“…Globally, fiscal practices, such as tax regulation and tariff structures, are critical for ensuring effective SWM services and achieving sustainable development goals. …”
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Strain rate dependence of dynamic recrystallization and texture evolution in hot compressed Mg-Gd-Er-Zr alloy by Ning Ding, Wenbo Du, Shubo Li, Ke Liu, Xian Du, Zijian Yu

“…The increment of DRX fraction is suggested to result from the reduced DRX critical strain and the increased dislocation density as well as velocity, while the weakened whole texture is attributed to the increased DRX grains. …”
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Archaeological Site Detection: Latest Results from a Deep Learning Based Europe Wide Hillfort Search by Jürgen Landauer, Simon Maddison, Giacomo Fontana, Axel G. Posluschny

“…While automation significantly reduces manual workload, human verification remains critical for refining AI predictions and addressing false positives. …”
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A qualitative exploration of owner experiences following dog adoption by Bethany Joy Moyer, Helen Zulch, Beth Ann Ventura, Oliver Burman

“…The adjustment period — wherein adopted animals transition to their new home — is a critical time for animal welfare and owner satisfaction, yet literature varies in estimates of how long this period lasts in dogs. …”
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Effect of Future Climate Change on Stratosphere-to-Troposphere-Exchange Driven Ozone in the Northern Hemisphere by Shovan Kumar Sahu, Lei Chen, Song Liu, Jia Xing, Rohit Mathur

“…Abstract Future estimates of atmospheric pollutant concentrations serve as critical information for policy makers to formulate current policy indicators to achieve future targets. …”
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Levistolide A and periplogenin inhibit the growth of gastric cancer cells in vitro and in vivo by Jia Li Guo, Hong Mei Hu, Shao Chin Lee, Ji Zhong Zhao

“…Aim: In the present study, the natural products levistolide A (LA) and periplogenin (PPG) were studied for their growth inhibitory effects on the development of gastric cancer cells in vitro and, more critically, in vivo, alone or in combination with the therapeutic medication 5-fluorouracil (5-FU). …”
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